2024
Expression of Random Sequences and de novo Evolved Genes From the Mouse in Human Cells Reveals Functional Diversity and Specificity
Aldrovandi S, Castro J, Ullrich K, Karger A, Luria V, Tautz D. Expression of Random Sequences and de novo Evolved Genes From the Mouse in Human Cells Reveals Functional Diversity and Specificity. Genome Biology And Evolution 2024, 16: evae175. PMID: 39663928, PMCID: PMC11635099, DOI: 10.1093/gbe/evae175.Peer-Reviewed Original ResearchConceptsOpen reading frameGene open reading frameCellular regulatory pathwaysNoncoding DNAReading frameHuman cell linesHuman genomeAlpha-helicesGrowth experimentsCellular physiologyFunctional diversityPositive selectionBeta-sheetTranscriptomic responseRegulatory pathwaysAdaptive advantageHuman cellsGenesCell clonesCell linesSequenceClonesRandom sequencePathwayCells
2016
The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity
Hanschen E, Marriage T, Ferris P, Hamaji T, Toyoda A, Fujiyama A, Neme R, Noguchi H, Minakuchi Y, Suzuki M, Kawai-Toyooka H, Smith D, Sparks H, Anderson J, Bakarić R, Luria V, Karger A, Kirschner M, Durand P, Michod R, Nozaki H, Olson B. The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity. Nature Communications 2016, 7: 11370. PMID: 27102219, PMCID: PMC4844696, DOI: 10.1038/ncomms11370.Peer-Reviewed Original ResearchConceptsEvolution of multicellularityCell cycle regulationCycle regulationVolvocine green algaeCell cycle regulatory pathwaysDomains of lifeGroup-level adaptationsCell cycle regulatorsGonium pectoraleEvolutionary transitionsUnicellular ChlamydomonasEvolutionary historyGreen algaeTractable systemGenome sequenceMulticellularityGenetic basisRegulatory pathwaysCycle regulatorsColonial algaInitial stepRegulationNumerous timesChlamydomonasGonium