2024
Expression of Random Sequences and de novo Evolved Genes From the Mouse in Human Cells Reveals Functional Diversity and Specificity
Aldrovandi S, Castro J, Ullrich K, Karger A, Luria V, Tautz D. Expression of Random Sequences and de novo Evolved Genes From the Mouse in Human Cells Reveals Functional Diversity and Specificity. Genome Biology And Evolution 2024, 16: evae175. PMID: 39663928, PMCID: PMC11635099, DOI: 10.1093/gbe/evae175.Peer-Reviewed Original ResearchConceptsOpen reading frameGene open reading frameCellular regulatory pathwaysNoncoding DNAReading frameHuman cell linesHuman genomeAlpha-helicesGrowth experimentsCellular physiologyFunctional diversityPositive selectionBeta-sheetTranscriptomic responseRegulatory pathwaysAdaptive advantageHuman cellsGenesCell clonesCell linesSequenceClonesRandom sequencePathwayCells
2019
The genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation
Kim H, Weber J, Lee N, Park S, Cho Y, Bhak Y, Lee N, Jeon Y, Jeon S, Luria V, Karger A, Kirschner M, Jo Y, Woo S, Shin K, Chung O, Ryu J, Yim H, Lee J, Edwards J, Manica A, Bhak J, Yum S. The genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation. BMC Biology 2019, 17: 28. PMID: 30925871, PMCID: PMC6441219, DOI: 10.1186/s12915-019-0643-7.Peer-Reviewed Original ResearchConceptsActive predationGene family expansionPosterior Hox genesFamily expansionAncient lineageBiochemical innovationHox genesBody planPhysiological traitsCodon biasType II familyGenetic basisGenomeClass ScyphozoaTranscriptomeDevelopmental stagesFirst animalEarly evolutionNeurotransmitter genesJellyfishCnidariansPredationRetinoic acidGenesKey innovation
2010
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou A, Barres B, Christiano A. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 2010, 464: 1043-1047. PMID: 20393562, PMCID: PMC3046868, DOI: 10.1038/nature08875.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninCell DifferentiationCell LineCell ProliferationChick EmbryoChromosome MappingChromosomes, Human, Pair 18Genes, DominantGenes, ReporterHairHair FollicleHumansHypotrichosisIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMembrane ProteinsMiceMutant ProteinsNeuronsPoint MutationScalpSignal TransductionSkinSpinal CordStem CellsWnt ProteinsXenopus laevisXenopus ProteinsConceptsHereditary hypotrichosis simplexSignal transduction pathwaysHypotrichosis simplexMesenchymal cell compartmentGenetic linkage analysisNovel Wnt inhibitorsMembrane-bound glycoproteinTransduction pathwaysHuman hair folliclesLinkage analysisAPCDD1Functional studiesHair folliclesWnt inhibitorsCell compartmentDowny hairsGenesImportant componentThick hairPathwayHairGlycoproteinCompartmentsDegenerative processFamily
2001
Expression patterns of Slit and Robo family members during vertebrate limb development
Vargesson N, Luria V, Messina I, Erskine L, Laufer E. Expression patterns of Slit and Robo family members during vertebrate limb development. Cells And Development 2001, 106: 175-180. PMID: 11472852, DOI: 10.1016/s0925-4773(01)00430-0.Peer-Reviewed Original Research