2024
Adherence to recommended prenatal visit schedules and risk for stillbirth, according to probable cause of death
Cersonsky T, Ayala N, Tucker N, Saade G, Dudley D, Pinar H, Silver R, Reddy U, Lewkowitz A. Adherence to recommended prenatal visit schedules and risk for stillbirth, according to probable cause of death. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2024, 303: 159-164. PMID: 39488137, DOI: 10.1016/j.ejogrb.2024.10.037.Peer-Reviewed Original ResearchRisk of stillbirthCause of deathIncreased risk of stillbirthHypertensive disordersPrenatal visit scheduleStillbirth Collaborative Research NetworkHigher risk of stillbirthSuboptimal prenatal careHypertensive disorders of pregnancyAssociated with higher riskDisorders of pregnancyVisit adherenceVisitation guidelinesPrenatal careSecondary analysisNon-adherenceVisit scheduleStillbirthIncreased riskMultivariate regressionStudy objectiveVisit frequencyPregnancyAdherenceGuidelinesOxytocin regimen used for induction of labor and pregnancy outcomes
REDDY U, SANDOVAL G, TITA A, SILVER R, MALLETT G, Kim H, EL-SAYED Y, RICE M, WAPNER R, ROUSE D, SAADE G, THORP J, CHAUHAN S, COSTANTINE M, CHIEN E, CASEY B, SRINIVAS S, SWAMY G, SIMHAN H, MACONES G, GROBMAN W, Network E. Oxytocin regimen used for induction of labor and pregnancy outcomes. American Journal Of Obstetrics & Gynecology MFM 2024, 6: 101508. PMID: 39357802, DOI: 10.1016/j.ajogmf.2024.101508.Peer-Reviewed Original ResearchInduction of laborLow-risk nulliparous patientsOxytocin regimensAdjusted relative risksAdjusted odds ratiosCesarean deliveryComposite of perinatal deathConfidence intervalsNeonatal respiratory supportLow-dose regimensHigh-dose oxytocin regimenSevere neonatal complicationsOperative vaginal delivery rateFrequency of cesarean deliverySecondary analysisEstimate adjusted relative risksElective induction of laborPerinatal deathRoutine induction of labourEstimate adjusted odds ratiosVaginal delivery rateRespiratory supportNulliparous patientsMHD groupMultivariable Poisson regressionAdverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery
Venkatesh K, Khan S, Yee L, Wu J, McNeil R, Greenland P, Chung J, Levine L, Simhan H, Catov J, Scifres C, Reddy U, Pemberton V, Saade G, Merz C, Grobman W, Mothers-to-Be A. Adverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery. Obstetrics And Gynecology 2024, 143: 775-784. PMID: 38574364, PMCID: PMC11098696, DOI: 10.1097/aog.0000000000005569.Peer-Reviewed Original ResearchConceptsRisk of atherosclerotic CVDAtherosclerotic CVD riskAdverse pregnancy outcomesHypertensive disorders of pregnancyAtherosclerotic CVDCVD riskDisorders of pregnancyPregnancy outcomesHypertensive disordersPreterm birthModified Poisson modelsFramingham risk scoreRisk of CVDRisk of atherosclerotic cardiovascular diseaseMagnitude of riskAbsolute riskAtherosclerotic cardiovascular diseaseSecondary analysisLongitudinal cohortRisk scoreGestational ageGreater riskBaseline covariatesCardiovascular diseaseDisease 2Prediction of metabolic syndrome following a first pregnancy
Kawakita T, Greenland P, Pemberton V, Grobman W, Silver R, Bairey Merz C, McNeil R, Haas D, Reddy U, Simhan H, Saade G. Prediction of metabolic syndrome following a first pregnancy. American Journal Of Obstetrics And Gynecology 2024 PMID: 38527600, PMCID: PMC11424779, DOI: 10.1016/j.ajog.2024.03.031.Peer-Reviewed Original ResearchDevelopment of metabolic syndromeArea under the receiver operating characteristic curveMetabolic syndromeNational Cholesterol Education Program Adult Treatment Panel III criteriaAdult Treatment Panel III criteriaPrevalence of metabolic syndromePrediction of metabolic syndromeProspective cohort studyIn-personSecondary analysisCohort studyIII criteriaInclusion criteriaPregnant individualsPrimary outcomeReceiver operating characteristic curveVisit 2Regression modelsPregnancySyndromeDeliveryUnited StatesCharacteristic curveLASSO regression modelYearsBreastfeeding Initiation, Duration, and Associated Factors Among People With Hepatitis C Virus Infection
Grasch J, de Voest J, Saade G, Hughes B, Reddy U, Costantine M, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S. Breastfeeding Initiation, Duration, and Associated Factors Among People With Hepatitis C Virus Infection. Obstetrics And Gynecology 2024, 143: 449-455. PMID: 38176013, PMCID: PMC10962006, DOI: 10.1097/aog.0000000000005499.Peer-Reviewed Original ResearchHepatitis C virus infectionUndetectable viral loadC virus infectionHuman immunodeficiency virusViral loadHCV seropositivityHCV viremiaBreast milkAssociated FactorsVirus infectionMulticenter observational cohortDetectable viral loadDuration of breastfeedingObstetric characteristicsSingleton gestationsMedian durationObservational cohortSecondary outcomesPrimary outcomeMultivariable analysisSelf-reported initiationImmunodeficiency virusBreastfeeding behaviorBreastfeedingSecondary analysis
2023
Neighborhood Socioeconomic Disadvantage and Abnormal Birth Weight
Venkatesh K, Yee L, Johnson J, Wu J, McNeil B, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Lynch C, Grobman W. Neighborhood Socioeconomic Disadvantage and Abnormal Birth Weight. Obstetrics And Gynecology 2023, 142: 1199-1207. PMID: 37769319, PMCID: PMC10972636, DOI: 10.1097/aog.0000000000005384.Peer-Reviewed Original ResearchAbnormal birth weightNeighborhood socioeconomic disadvantageGestational ageBirth weightPregnant individualsADI quartileIncreased oddsSocioeconomic disadvantageWeeks of gestationPotential confounding variablesLogistic regression modelsHigher area deprivationSGA neonatesLGA neonatesMultinomial logistic regression modelsSingleton gestationsCohort enrollmentAnalytic populationParticipant's addressFetal sexConfounding variablesSecondary analysisArea deprivationNeonatesQuartileBreastfeeding initiation and duration among people with mild chronic hypertension: a secondary analysis of the Chronic Hypertension and Pregnancy trial
Goulding A, Antoniewicz L, Leach J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Harper L, Ambalavanan N, Oparil S, Szychowski J, Tita A, Consortium C. Breastfeeding initiation and duration among people with mild chronic hypertension: a secondary analysis of the Chronic Hypertension and Pregnancy trial. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101086. PMID: 37437694, PMCID: PMC10528420, DOI: 10.1016/j.ajogmf.2023.101086.Peer-Reviewed Original ResearchConceptsDuration of breastfeedingChronic hypertensionMild chronic hypertensionPostpartum clinic visitPostpartum study visitsGoal blood pressureBlood pressure measurementsPostpartum visitTreatment groupsBlood pressureBreastfeeding outcomesPregnancy trialSecondary analysisClinic visitsBreastfeeding goalsStudy visitBlood pressure treatment strategiesLong-term breastfeeding outcomesBivariate analysisMaternal cardiovascular healthActive treatment groupBlood pressure controlEarlier gestational ageHigh-risk populationWeeks of breastfeedingCopy number variants and fetal structural abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study
Workalemahu T, Dalton S, Son S, Allshouse A, Carey A, Page J, Blue N, Thorsten V, Goldenberg R, Pinar H, Reddy U, Silver R. Copy number variants and fetal structural abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study. BJOG An International Journal Of Obstetrics & Gynaecology 2023, 131: 157-162. PMID: 37264725, PMCID: PMC10689565, DOI: 10.1111/1471-0528.17561.Peer-Reviewed Original ResearchConceptsCopy number variantsFetal structural malformationsAbnormal copy number variantsNumber variantsSingle nucleotide polymorphism arrayResearch Network StudyStillbirth casesDNA copy number variantsSpecific copy number variantsCardiac defectsPolymorphism arrayStructural malformationsSecondary analysisCraniofacial defectsGenesSpecific malformation typesFetal structural abnormalitiesWald chi-square testUnknown clinical significanceChi-square testKbSkeletal defectsBenign copy number variantsPathogenic deletionsClinical significanceOutcomes of induction vs prelabor cesarean delivery at <33 weeks for hypertensive disorders of pregnancy
Bushman E, Grobman W, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Outcomes of induction vs prelabor cesarean delivery at <33 weeks for hypertensive disorders of pregnancy. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101032. PMID: 37244639, PMCID: PMC10521213, DOI: 10.1016/j.ajogmf.2023.101032.Peer-Reviewed Original ResearchConceptsPrelabor cesarean deliveryHypertensive disordersInduction of laborCesarean deliveryLabor inductionNeonatal morbidityInduction groupMedian durationVaginal deliveryWeeks' gestationSecondary analysisAdverse composite outcomeComposite maternal morbidityOutcome of inductionPreterm hypertensive disordersHalf of patientsCesarean delivery groupLength of inductionOptimal delivery approachMaternal morbidityComposite outcomeFetal malpresentationMultiple gestationsPreterm birthSecondary outcomesHypertension in Pregnancy and Adverse Outcomes Among Low-risk Nulliparous Women Expectantly Managed at or After 39 weeks: A Secondary Analysis of a Randomized Controlled Trial
Bartal M, Premkumar A, Rice M, Reddy U, Tita A, Silver R, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Constantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H. Hypertension in Pregnancy and Adverse Outcomes Among Low-risk Nulliparous Women Expectantly Managed at or After 39 weeks: A Secondary Analysis of a Randomized Controlled Trial. Obstetric Anesthesia Digest 2023, 43: 82-82. DOI: 10.1097/01.aoa.0000927856.60760.92.Peer-Reviewed Original ResearchLow-risk patientsLow-risk nulliparous womenHypertensive disordersMaternal morbidityMaternal outcomesNulliparous womenControlled TrialsWeeks' gestationAdverse outcomesLower riskSecondary analysisPregnancyPatientsHDPOutcomesRecent studiesHypertensionMorbidityGestationMortalityPrevalenceTrialsWeeksWomenAssociation of Neighborhood Socioeconomic Disadvantage and Postpartum Readmission
Meiman J, Grobman W, Haas D, Yee L, Wu J, McNeil B, Wu J, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Lynch C, Venkatesh K. Association of Neighborhood Socioeconomic Disadvantage and Postpartum Readmission. Obstetrics And Gynecology 2023, 141: 967-970. PMID: 37026732, PMCID: PMC10147577, DOI: 10.1097/aog.0000000000005151.Peer-Reviewed Original ResearchConceptsArea Deprivation IndexPostpartum readmissionNeighborhood socioeconomic disadvantageNeighbourhood deprivationSocioeconomic disadvantageWeeks of deliveryAdverse social determinantsProspective cohortPostpartum careDelivery dischargePregnant individualsReadmissionPoisson regressionSecondary analysisSocial determinantsDeprivation indexAssessed individualsRiskDeprivationIndividualsPostpartumCohortQuartileWeeksCare
2022
Hypertension in pregnancy and adverse outcomes among low‐risk nulliparous women expectantly managed at or after 39 weeks: a secondary analysis of a randomised controlled trial
Bartal M, Premkumar A, Rice M, Reddy U, Tita ATN, Silver RM, El‐Sayed Y, Wapner R, Rouse DJ, Saade GR, Thorp JM, Costantine M, Chien EK, Casey BM, Srinivas SK, Swamy GK, Simhan HN, Health H. Hypertension in pregnancy and adverse outcomes among low‐risk nulliparous women expectantly managed at or after 39 weeks: a secondary analysis of a randomised controlled trial. BJOG An International Journal Of Obstetrics & Gynaecology 2022, 129: 1396-1403. PMID: 34927787, PMCID: PMC9207156, DOI: 10.1111/1471-0528.17059.Peer-Reviewed Original ResearchConceptsAdverse maternal outcomesLow-risk nulliparous womenHypertensive disordersMaternal outcomesSecondary outcomesNulliparous womenAdverse outcomesComposite adverse maternal outcomeIntensive care unit admissionSecondary analysisCare unit admissionSevere neonatal complicationsWeeks of gestationMode of deliveryNulliparous individualsMaternal compositeNeonatal complicationsPerinatal compositePostpartum infectionUnit admissionCaesarean deliveryExpectant managementPlacental abruptionVenous thromboembolismGestational age
2021
Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network
Arslan E, Allshouse A, Page J, Varner M, Thorsten V, Parker C, Dudley D, Saade G, Goldenberg R, Stoll B, Hogue C, Bukowski R, Conway D, Pinar H, Reddy U, Silver R. Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 619-626. PMID: 34529344, DOI: 10.1111/1471-0528.16922.Peer-Reviewed Original ResearchConceptsSerum fructosamine levelsFructosamine levelsCase-control studyTime of deliveryLive birthsStillbirth Collaborative Research NetworkLive birth controlsCases of stillbirthPotential confounding factorsGeographic catchment areaSingleton stillbirthsGlycaemic controlDiabetes statusMulticentre studyRoutine screeningFructosamine measurementsDiabetesStillbirthConfounding factorsSecondary analysisWomenBirthCollaborative research networksBirth controlResearch NetworkMaternal and Neonatal Outcomes in Nulliparous Participants Undergoing Labor Induction by Cervical Ripening Method
Andrikopoulou M, Bushman E, Rice M, Grobman W, Reddy U, Silver R, El-Sayed Y, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H. Maternal and Neonatal Outcomes in Nulliparous Participants Undergoing Labor Induction by Cervical Ripening Method. American Journal Of Perinatology 2021, 40: 1061-1070. PMID: 34352922, PMCID: PMC8817048, DOI: 10.1055/s-0041-1732379.Peer-Reviewed Original ResearchConceptsAdverse neonatal outcomesCervical ripeningNeonatal outcomesLabor inductionNulliparous participantsComposite outcomeAdverse maternal outcomesCervical ripening methodsMaternal composite outcomeNeonatal composite outcomeLow-risk womenLength of laborConcurrent oxytocinCoprimary outcomesNeonatal compositeExpectant managementMaternal outcomesCesarean deliverySecondary outcomesFetal demisePatient characteristicsMultivariable analysisCervical dilationLower riskSecondary analysis
2019
Duration of Operative Vaginal Delivery and Adverse Obstetric Outcomes
Miller E, Lai Y, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Leveno K, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Duration of Operative Vaginal Delivery and Adverse Obstetric Outcomes. American Journal Of Perinatology 2019, 37: 503-510. PMID: 30895577, PMCID: PMC6754310, DOI: 10.1055/s-0039-1683439.Peer-Reviewed Original ResearchConceptsComposite adverse neonatal outcomeAdverse neonatal outcomesOperative vaginal deliveryNeonatal outcomesVaginal deliveryMulticenter observational cohortAdverse obstetric outcomesSevere perineal lacerationsObstetric outcomesPerinatal outcomesObservational cohortPerineal lacerationsPrimary cohortForceps applicationPotential confoundersSecondary analysisStrong associationOutcomesWomenCohortDurationDeliveryLacerationConfoundersForceps
2017
Diagnostic Tests for Evaluation of Stillbirth
Page JM, Christiansen-Lindquist L, Thorsten V, Parker CB, Reddy UM, Dudley DJ, Saade GR, Coustan D, Hogue C, Conway D, Bukowski R, Pinar H, Heuser CC, Gibbins KJ, Goldenberg RL, Silver RM. Diagnostic Tests for Evaluation of Stillbirth. Obstetrics And Gynecology 2017, 129: 699-706. PMID: 28333795, DOI: 10.1097/aog.0000000000001937.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkCause of deathAntiphospholipid antibodiesPlacental pathologyDiagnostic testsEvaluation of stillbirthMedical record abstractionPopulation-based studyCollaborative research networksDeath classification systemResearch NetworkRecord abstractionSyphilis serologyClinical presentationToxicology screenAntibody screenClinical historyMaternal interviewsStillbirthSecondary analysisGenetic testingUseful testBiospecimen collectionStandardized evaluationMost participants
2016
Stillbirth, hypertensive disorders of pregnancy, and placental pathology
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta 2016, 43: 61-68. PMID: 27324101, PMCID: PMC5893308, DOI: 10.1016/j.placenta.2016.04.020.Peer-Reviewed Original ResearchConceptsPlacental pathologyParenchymal infarctionLive birthsPreterm stillbirthSimilar clinical risk factorsStillbirth Collaborative Research NetworkPopulation-based cohort studyFetal vascular lesionsClinical risk factorsFeto-placental ratioGestational hypertensionRetroplacental hematomaHypertensive disordersCohort studyPlacental lesionsVascular lesionsAvascular villiFibrin depositionRisk factorsVascular thrombiStillbirthPregnancySecondary analysisInfarctionGH
2015
Neonatal complications associated with use of fetal scalp electrode: a retrospective study
Kawakita T, Reddy U, Landy H, Iqbal, Huang C, Grantz K. Neonatal complications associated with use of fetal scalp electrode: a retrospective study. BJOG An International Journal Of Obstetrics & Gynaecology 2015, 123: 1797-1803. PMID: 26643181, PMCID: PMC4899296, DOI: 10.1111/1471-0528.13817.Peer-Reviewed Original ResearchConceptsFetal scalp electrodeVacuum-assisted vaginal deliveryVaginal deliveryOperative vaginal deliveryWeeks of gestationNeonatal complicationsScalp electrodesNeonatal morbidityForceps-assisted vaginal deliveryNon-operative vaginal deliveriesSecondary analysisPrelabour caesarean deliveryRetrospective cohort studyAssisted vaginal deliveryRisk of complicationsSafe Labor studyRisk of injuryCaesarean deliveryPregnancy complicationsCohort studySingleton deliveriesNeonatal risksRetrospective studyUnderlying indicationAbsolute riskDoes the Presence of a Condition-Specific Obstetric Protocol Lead to Detectable Improvements in Pregnancy Outcomes?
Bailit J, Grobman W, McGee P, Reddy U, Wapner R, Varner M, Thorp J, Leveno K, Iams J, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S. Does the Presence of a Condition-Specific Obstetric Protocol Lead to Detectable Improvements in Pregnancy Outcomes? Obstetrical & Gynecological Survey 2015, 70: 679-680. DOI: 10.1097/01.ogx.0000473082.76430.62.Peer-Reviewed Original ResearchPostpartum hemorrhageSpecific complicationsHemorrhage protocolShoulder dystociaIntensive care unit admissionCare unit admissionRate of hemorrhageRisk-adjusted patient outcomesShoulder dystocia maneuversObstetric protocolsUnit admissionObstetric outcomesSevere hypertensionCohort studyPregnancy outcomesBlood lossSingle centerPatient outcomesImproved outcomesHigh-quality protocolsComplicationsHospitalSecondary analysisHemorrhagePatient safetyCluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms
Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthDecidual hemorrhagePlacental dysfunctionProspective case-control multicenter studyCase-control multicenter studyPremature membrane ruptureGroup of womenCommon biologic pathwaysMaternal comorbiditiesPreterm singletonsPreterm birthWeeks' gestationMulticenter studyMaternal stressSecondary analysisBiologic pathwaysFamilial factorsGenetic factorsWomenPhenotypic profileGestationInfectionMembrane ruptureCommon mechanismPhenotype