2024
Blood Pressure Control in Pregnant Patients with Chronic Hypertension and Diabetes: Should <130/80 be the Target?
Harper L, Kuo H, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Galis Z, Ambalavanan N, Oparil S, Szychowski J, Tita A. Blood Pressure Control in Pregnant Patients with Chronic Hypertension and Diabetes: Should <130/80 be the Target? American Journal Of Obstetrics And Gynecology 2024 PMID: 39288828, DOI: 10.1016/j.ajog.2024.09.006.Peer-Reviewed Original ResearchTarget blood pressureNeonatal intensive care unitLow blood pressure groupBlood pressure groupPerinatal outcomesAverage blood pressureChronic hypertensionMm HgBlood pressureCesarean deliveryNeonatal deathDiastolic BPRisk of NICU admissionCompare perinatal outcomesEvaluate risk ratiosLt;130/80 mm HgPreterm birth <Adverse perinatal outcomesMultivariable log-binomial regression modelsGoal blood pressureAverage diastolic BPPrimary composite outcomeSystolic BP <Log-binomial regression modelsAntenatal blood pressurePregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks, Gestation
Woolcock H, Parra N, Zhang Y, Reddy U, Bello N, Miller E, Booker W. Pregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks, Gestation. American Journal Of Perinatology 2024, 41: 2135-2143. PMID: 38569509, PMCID: PMC11496016, DOI: 10.1055/a-2298-5347.Peer-Reviewed Original ResearchAssociated with adverse pregnancy outcomesFetal growth restrictionPlacental abruptionWeeks gestationBlood pressureElevated BPAmerican Heart AssociationPregnancy outcomesNormal BPOdds of fetal growth restrictionIncreased riskOdds of placental abruptionAmerican CollegeMultivariable-adjusted odds ratioAssociated with HDPAdverse pregnancy outcomesWeeks of pregnancyProspective cohort studyElevated blood pressureConfidence intervalsStage I hypertensionAmerican College of Cardiology (ACCCesarean deliveryPreterm deliverySingleton pregnancies
2023
Breastfeeding initiation and duration among people with mild chronic hypertension: a secondary analysis of the Chronic Hypertension and Pregnancy trial
Goulding A, Antoniewicz L, Leach J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Harper L, Ambalavanan N, Oparil S, Szychowski J, Tita A, Consortium C. Breastfeeding initiation and duration among people with mild chronic hypertension: a secondary analysis of the Chronic Hypertension and Pregnancy trial. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101086. PMID: 37437694, PMCID: PMC10528420, DOI: 10.1016/j.ajogmf.2023.101086.Peer-Reviewed Original ResearchConceptsDuration of breastfeedingChronic hypertensionMild chronic hypertensionPostpartum clinic visitPostpartum study visitsGoal blood pressureBlood pressure measurementsPostpartum visitTreatment groupsBlood pressureBreastfeeding outcomesPregnancy trialSecondary analysisClinic visitsBreastfeeding goalsStudy visitBlood pressure treatment strategiesLong-term breastfeeding outcomesBivariate analysisMaternal cardiovascular healthActive treatment groupBlood pressure controlEarlier gestational ageHigh-risk populationWeeks of breastfeedingHypertensive Disorders of Pregnancy and Long-Term Maternal Cardiovascular and Metabolic Biomarkers
Battarbee A, Mele L, Landon M, Varner M, Casey B, Reddy U, Wapner R, Rouse D, Thorp J, Chien E, Saade G, Peaceman A, Blackwell S. Hypertensive Disorders of Pregnancy and Long-Term Maternal Cardiovascular and Metabolic Biomarkers. American Journal Of Perinatology 2023, 41: e1976-e1981. PMID: 37201538, PMCID: PMC10755076, DOI: 10.1055/a-2096-0443.Peer-Reviewed Original ResearchBaseline body mass indexHypertensive disordersGestational hypertensionCardiovascular biomarkersHigher baseline blood pressureLow GDF-15 levelsAssociation of HDPPresence of HDPGDF-15 levelsBaseline blood pressureHomeostatic model assessmentBody mass indexStudy of patientsSerum insulin concentrationsLongitudinal studyMultivariable linear regressionChronic hypertensionGDM cohortPregnancy hypertensionGDF-15Insulinogenic indexPostpartum interventionsBlood pressureMass indexCardiovascular dysfunction
2021
Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study
Grover S, Brandt J, Reddy U, Ananth C. Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 572-579. PMID: 34536318, PMCID: PMC9214277, DOI: 10.1111/1471-0528.16932.Peer-Reviewed Original ResearchConceptsPerinatal mortality rateChronic hypertensionEarly term deliveryPreterm deliveryPerinatal mortalityMortality rateTerm deliverySingleton birthsCausal mediation analysisMaternal chronic hypertensionElevated blood pressureModifiable risk factorsPopulation-based studyWeeks of gestationLate-term gestationCross-sectional analysisNormotensive pregnanciesPreterm birthBlood pressureTerm gestationPerinatal deathRisk factorsHypertensionMAIN OUTCOMEMortality
2019
Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes
Casey B, Rice M, Landon M, Varner M, Reddy U, Wapner R, Rouse D, Biggio J, Thorp J, Chien E, Saade G, Peaceman A, Blackwell S, Van Dorsten J. Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes. American Journal Of Perinatology 2019, 37: 475-482. PMID: 30866027, PMCID: PMC6744360, DOI: 10.1055/s-0039-1681058.Peer-Reviewed Original ResearchConceptsMild gestational diabetes mellitusGestational diabetes mellitusBody mass indexMetabolic syndromeIndex pregnancyTreatment of womenSubsequent diabetesLong-term maternal outcomesMaternal body mass indexOral glucose tolerance testMild gestational diabetesFrequency of diabetesHomeostasis model assessmentGlucose tolerance testRisk of diabetesTreatment of diabetesEffect of treatmentRace/ethnicityGestational diabetesLipid panelMaternal outcomesBlood pressureDiabetes mellitusMedical therapyNutritional counseling