Featured Publications
Detecting model misconducts in decentralized healthcare federated learning
Kuo T, Pham A. Detecting model misconducts in decentralized healthcare federated learning. International Journal Of Medical Informatics 2021, 158: 104658. PMID: 34923447, PMCID: PMC10017272, DOI: 10.1016/j.ijmedinf.2021.104658.Peer-Reviewed Original ResearchFederated learningFederated machine learningDetection methodDetection frameworkLearning iterationsMalicious intentLearning methodsMachine learningArtificial intelligenceParameter tuningComputational costCross-institutional collaborationLearningLearning processIterationPerformance detectorsDetectionIncorrect modelFrameworkAlgorithmDatasetDetect misconductIntelligencePlagiarismMethod
2025
Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history
ham A, El-Kareh R, Myers F, Ohno-Machado L, Kuo T-T. Predicting positive clostridioides difficile test results using large-scale longitudinal data of demographics and medication history. Heliyon. 2025;11(1). DOI: 10.1016/j.heliyon.2024.e41350.Peer-Reviewed Original Research
2024
Distributed, immutable, and transparent biomedical limited data set request management on multi-capacity network
Yu Y, Edelson M, Pham A, Pekar J, Johnson B, Post K, Kuo T. Distributed, immutable, and transparent biomedical limited data set request management on multi-capacity network. Journal Of The American Medical Informatics Association 2024, ocae288. PMID: 39569448, DOI: 10.1093/jamia/ocae288.Peer-Reviewed Original ResearchBlockchain-based systemSmart contractsMedical data managementData access processReal-world scenariosData access historyRuntime metricsAccess transparencyAudit logMetadata InitiativeNetwork speedPerformance gainsSharing requestsAccess historyRequest managementHardware specificationsComputing capacityAverage runtimeData managementSharing processSynthetic dataRequest timeQueryAudit trailData linksWebQuorumChain: A web framework for quorum-based health care model learning
Shao X, Pham A, Kuo T. WebQuorumChain: A web framework for quorum-based health care model learning. Informatics In Medicine Unlocked 2024, 50: 101590. PMID: 39483487, PMCID: PMC11526443, DOI: 10.1016/j.imu.2024.101590.Peer-Reviewed Original ResearchExecution timeBack-endDecentralized federated learningDecentralized machine learningFederated learning networkFront-endAverage execution timeBack-end layerBack-end functionsWeb-based systemData-driven discoveryFederated learningPrivacy-preservingData privacyPrivacy concernsRuntime efficiencyCollaborative machinesWeb frameworkModel learningSecurity promisesSystem overheadsLow-level processingLearning networkMachine learningVisualization toolsSecure Federated Learning Integrated Statistical Modeling for Healthcare Data
Jiang X, Kim J, Kuo T, Ohno-Machado L. Secure Federated Learning Integrated Statistical Modeling for Healthcare Data. 2024, 313-324. DOI: 10.1201/9781003185284-24.Peer-Reviewed Original ResearchDistributed management of patient data-sharing informed consents for clinical research
Pham A, Edelson M, Nouri A, Kuo T. Distributed management of patient data-sharing informed consents for clinical research. Computers In Biology And Medicine 2024, 180: 108956. PMID: 39121682, PMCID: PMC11380755, DOI: 10.1016/j.compbiomed.2024.108956.Peer-Reviewed Original ResearchBenefits of immutabilityBlockchain-based infrastructureMulti-site scenarioResearch Data AccessNode parallelismOn-chainNetwork nodesData accessAudit trailPatient privacyDistribution managementConsent mechanismsData categoriesNodesEfficient wayNetworkAutomated channelAccuracyQueryPrivacyImmutabilityOrchestrationConsent protocolDataExhaustive listBiomedical blockchain with practical implementations and quantitative evaluations: a systematic review
Lacson R, Yu Y, Kuo T, Ohno-Machado L. Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review. Journal Of The American Medical Informatics Association 2024, 31: 1423-1435. PMID: 38726710, PMCID: PMC11105130, DOI: 10.1093/jamia/ocae084.Peer-Reviewed Original ResearchConceptsElectronic health recordsSystematic reviewData sharingMedical data sharingSpeed metricsPreferred Reporting ItemsCertificate storageDecentralized InternetNetwork permissionsBlockchain platformBlockchain applicationsEvaluation metricsBiomedical domainBlockchainBiomedical data managementHealth recordsData managementData storageReporting ItemsHealth sectorQuantitative metricsMedical facilitiesMetricsTrial managementClinical trial managementEarly prediction of long hospital stay for Intensive Care units readmission patients using medication information
Zhang M, Kuo T. Early prediction of long hospital stay for Intensive Care units readmission patients using medication information. Computers In Biology And Medicine 2024, 174: 108451. PMID: 38603899, PMCID: PMC11385457, DOI: 10.1016/j.compbiomed.2024.108451.Peer-Reviewed Original ResearchConceptsIntensive care unitProlonged ICU LOSAverage doseICU LOSLonger hospital stayReceiver operating characteristic curveLogistic regressionPredicting intensive care unitMedical informationExpected Calibration ErrorSummed dosePatient ageHospital staySupport vector machineCare unitMIMIC-IV databasePatient complicationsCharacteristic curveMedicationRandom forestDosePatient recordsAdmissionReadmission patientsSecure Federated Learning Integrated Statistical Modeling for Healthcare Data
Xiaoqian Jiang, Jihoon Kim, Tsung-Ting Kuo, Lucila Ohno-Machado, “Secure Federated Learning Integrated Statistical Modeling for Healthcare Data.” Handbook of Sharing Confidential Data: Differential Privacy, Secure Multiparty Computation, and Synthetic Data, 2024.Chapters
2023
Editorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare
Kuo T, Zhang P. Editorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare. Frontiers In Blockchain 2023, 6: 1275474. DOI: 10.3389/fbloc.2023.1275474.Commentaries, Editorials and LettersBlockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions
Kuo T, Pham A, Edelson M, Kim J, Chan J, Gupta Y, Ohno-Machado L, Anderson D, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bell D, Bernstam E, Ngan C, Day M, Doctor J, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hinske L, Hu Z, Ir D, Jiang X, Kim K, Kim J, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Matheny M, Meeker D, Mou Z, Neumann L, Nguyen N, Nick A, Ohno-Machado L, Park E, Paul P, Pletcher M, Post K, Rieder C, Scherer C, Schilling L, Soares A, SooHoo S, Soysal E, Steven C, Tep B, Toy B, Wang B, Wu Z, Xu H, Yong C, Zheng K, Zhou Y, Zucker R. Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions. Journal Of The American Medical Informatics Association 2023, 30: 1167-1178. PMID: 36916740, PMCID: PMC10198529, DOI: 10.1093/jamia/ocad049.Peer-Reviewed Original ResearchConceptsFederated data analysisUser activity logsSmart contract deploymentRun-time efficiencyData analysis systemData analysis activitiesActivity logsData discoveryQuerying timeBlockchain systemBlockchain technologyNetwork transactionsCOVID-19 data analysisMultiple institutionsLow deploymentBlockchainGitHub repositoryMultiple nodesLarge networksQueriesAnalysis activitiesHigh availabilityLanguage codeBaseline solutionData analysisA hierarchical strategy to minimize privacy risk when linking “De-identified” data in biomedical research consortia
Ohno-Machado L, Jiang X, Kuo T, Tao S, Chen L, Ram P, Zhang G, Xu H. A hierarchical strategy to minimize privacy risk when linking “De-identified” data in biomedical research consortia. Journal Of Biomedical Informatics 2023, 139: 104322. PMID: 36806328, PMCID: PMC10975485, DOI: 10.1016/j.jbi.2023.104322.Peer-Reviewed Original ResearchConceptsPrivacy of individualsAppropriate privacy protectionData-driven modelsPrivacy protectionPrivacy risksData Coordination CenterData hubData repositoryHierarchical strategyPrivacyBiomedical discoveryData setsRecord linkageData Coordinating CenterRepositoryComplex strategiesCoordination centerTechnologyTechniqueDataPartiesSetHierarchy
2022
Quorum-based model learning on a blockchain hierarchical clinical research network using smart contracts
Kuo T, Pham A. Quorum-based model learning on a blockchain hierarchical clinical research network using smart contracts. International Journal Of Medical Informatics 2022, 169: 104924. PMID: 36402113, PMCID: PMC9984225, DOI: 10.1016/j.ijmedinf.2022.104924.Peer-Reviewed Original ResearchConceptsSmart contractsPrivacy-preserving modelHierarchical learning algorithmBlockchain smart contractsProtect patient privacyLearning algorithmsNetwork of networksConsensus protocolModeling processPatient privacyQuorum mechanismHierarchical networkAvailability issuesNetworkPrediction correctnessIterative phasesPrediction modelPrivacyImmutabilityCapabilityHealthcare institutionsAlgorithmDatasetIterationLearning continuityThe evolving privacy and security concerns for genomic data analysis and sharing as observed from the iDASH competition
Kuo T, Jiang X, Tang H, Wang X, Harmanci A, Kim M, Post K, Bu D, Bath T, Kim J, Liu W, Chen H, Ohno-Machado L. The evolving privacy and security concerns for genomic data analysis and sharing as observed from the iDASH competition. Journal Of The American Medical Informatics Association 2022, 29: 2182-2190. PMID: 36164820, PMCID: PMC9667175, DOI: 10.1093/jamia/ocac165.Peer-Reviewed Original ResearchConceptsSensitive personal informationGenomic data analysisPotential future research directionsPersonal informationSecurity concernsGenomics data repositoryData repositoryReport lessonsProtection techniquesFuture research directionsPrivacyResearch directionsData usePractical challengesGenomic dataData analysisAnonymizationCommunity effortsRepositorySecurityBiomedical researchInformationDataChallengesPredicting COVID-19 county-level case number trend by combining demographic characteristics and social distancing policies
Li M, Pham A, Kuo T. Predicting COVID-19 county-level case number trend by combining demographic characteristics and social distancing policies. JAMIA Open 2022, 5: ooac056. PMID: 35855422, PMCID: PMC9278037, DOI: 10.1093/jamiaopen/ooac056.Peer-Reviewed Original ResearchNLM’s sponsorship of research in biomedical informatics (1985–2016)
Kuo T, Ohno-Machado L. NLM’s sponsorship of research in biomedical informatics (1985–2016). Information Services & Use 2022, 42: 61-70. PMID: 35600120, PMCID: PMC9108565, DOI: 10.3233/isu-210137.Peer-Reviewed Original ResearchGeneralizable prediction of COVID-19 mortality on worldwide patient data
Edelson M, Kuo T. Generalizable prediction of COVID-19 mortality on worldwide patient data. JAMIA Open 2022, 5: ooac036. PMID: 35663116, PMCID: PMC9129227, DOI: 10.1093/jamiaopen/ooac036.Peer-Reviewed Original ResearchCertificateChain: decentralized healthcare training certificate management system using blockchain and smart contracts
Tellew J, Kuo T. CertificateChain: decentralized healthcare training certificate management system using blockchain and smart contracts. JAMIA Open 2022, 5: ooac019. PMID: 35571362, PMCID: PMC9097703, DOI: 10.1093/jamiaopen/ooac019.Peer-Reviewed Original ResearchCertificate management systemSingle-point-of-failureManagement systemAutomated smart contractsPublic Ethereum networkBlockchain networkEthereum networkOff-chainOn-chainSmart contractsBlockchain technologyConsensus protocolBlockchainWeb appDecentralized alternativeCentralized systemNetworkCentral databaseTrainingAlgorithmSystemTraining certificationDatabaseCertificationSoftware
2021
Previewable Contract-Based On-Chain X-Ray Image Sharing Framework for Clinical Research
Li M, Kuo T. Previewable Contract-Based On-Chain X-Ray Image Sharing Framework for Clinical Research. International Journal Of Medical Informatics 2021, 156: 104599. PMID: 34628257, PMCID: PMC8479449, DOI: 10.1016/j.ijmedinf.2021.104599.Peer-Reviewed Original ResearchConceptsSharing frameworkPreview featureSoftware consistBlockchain-based frameworkChest X-ray imagesBlockchain networkSoftware inconsistencySmart contractsMerging functionView imagesBlockchainImprove sharingX-ray imagesFrameworkImagesLatencyInteroperabilityImmutabilityNetworkFeaturesData analysisSoftwareCodePreviewDownstream data analysisBenchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track
Kuo T, Bath T, Ma S, Pattengale N, Yang M, Cao Y, Hudson C, Kim J, Post K, Xiong L, Ohno-Machado L. Benchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track. International Journal Of Medical Informatics 2021, 154: 104559. PMID: 34474309, PMCID: PMC9933142, DOI: 10.1016/j.ijmedinf.2021.104559.Peer-Reviewed Original ResearchConceptsSecure genome analysis competitionData retrieval queriesBlockchain-based methodData sharing methodReal-world problemsQuery indexType of sharingRetrieval queriesBlockchain technologyLedger technologySource codeBlockchain utilizationBlockchain strategyHealthcare applicationsInteraction recordsSharing methodTest datasetSharing recordsBiomedical research applicationsConsortium resourcesNew platformPatient recordsBlockchainQueriesTechnology