2024
Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review
Lacson R, Yu Y, Kuo T, Ohno-Machado L. Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review. Journal Of The American Medical Informatics Association 2024, 31: 1423-1435. PMID: 38726710, PMCID: PMC11105130, DOI: 10.1093/jamia/ocae084.Peer-Reviewed Original ResearchConceptsElectronic health recordsSystematic reviewData sharingMedical data sharingSpeed metricsPreferred Reporting ItemsCertificate storageDecentralized InternetNetwork permissionsBlockchain platformBlockchain applicationsEvaluation metricsBiomedical domainBlockchainBiomedical data managementHealth recordsData managementData storageReporting ItemsHealth sectorQuantitative metricsMedical facilitiesMetricsTrial managementClinical trial management
2023
Editorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare
Kuo T, Zhang P. Editorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare. Frontiers In Blockchain 2023, 6: 1275474. DOI: 10.3389/fbloc.2023.1275474.Commentaries, Editorials and LettersBlockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions
Kuo T, Pham A, Edelson M, Kim J, Chan J, Gupta Y, Ohno-Machado L, Anderson D, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bell D, Bernstam E, Ngan C, Day M, Doctor J, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hinske L, Hu Z, Ir D, Jiang X, Kim K, Kim J, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Matheny M, Meeker D, Mou Z, Neumann L, Nguyen N, Nick A, Ohno-Machado L, Park E, Paul P, Pletcher M, Post K, Rieder C, Scherer C, Schilling L, Soares A, SooHoo S, Soysal E, Steven C, Tep B, Toy B, Wang B, Wu Z, Xu H, Yong C, Zheng K, Zhou Y, Zucker R. Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions. Journal Of The American Medical Informatics Association 2023, 30: 1167-1178. PMID: 36916740, PMCID: PMC10198529, DOI: 10.1093/jamia/ocad049.Peer-Reviewed Original ResearchConceptsFederated data analysisUser activity logsSmart contract deploymentRun-time efficiencyData analysis systemData analysis activitiesActivity logsData discoveryQuerying timeBlockchain systemBlockchain technologyNetwork transactionsCOVID-19 data analysisMultiple institutionsLow deploymentBlockchainGitHub repositoryMultiple nodesLarge networksQueriesAnalysis activitiesHigh availabilityLanguage codeBaseline solutionData analysis
2022
CertificateChain: decentralized healthcare training certificate management system using blockchain and smart contracts
Tellew J, Kuo T. CertificateChain: decentralized healthcare training certificate management system using blockchain and smart contracts. JAMIA Open 2022, 5: ooac019. PMID: 35571362, PMCID: PMC9097703, DOI: 10.1093/jamiaopen/ooac019.Peer-Reviewed Original ResearchCertificate management systemSingle-point-of-failureManagement systemAutomated smart contractsPublic Ethereum networkBlockchain networkEthereum networkOff-chainOn-chainSmart contractsBlockchain technologyConsensus protocolBlockchainWeb appDecentralized alternativeCentralized systemNetworkCentral databaseTrainingAlgorithmSystemTraining certificationDatabaseCertificationSoftware
2021
Previewable Contract-Based On-Chain X-Ray Image Sharing Framework for Clinical Research
Li M, Kuo T. Previewable Contract-Based On-Chain X-Ray Image Sharing Framework for Clinical Research. International Journal Of Medical Informatics 2021, 156: 104599. PMID: 34628257, PMCID: PMC8479449, DOI: 10.1016/j.ijmedinf.2021.104599.Peer-Reviewed Original ResearchConceptsSharing frameworkPreview featureSoftware consistBlockchain-based frameworkChest X-ray imagesBlockchain networkSoftware inconsistencySmart contractsMerging functionView imagesBlockchainImprove sharingX-ray imagesFrameworkImagesLatencyInteroperabilityImmutabilityNetworkFeaturesData analysisSoftwareCodePreviewDownstream data analysisBenchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track
Kuo T, Bath T, Ma S, Pattengale N, Yang M, Cao Y, Hudson C, Kim J, Post K, Xiong L, Ohno-Machado L. Benchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track. International Journal Of Medical Informatics 2021, 154: 104559. PMID: 34474309, PMCID: PMC9933142, DOI: 10.1016/j.ijmedinf.2021.104559.Peer-Reviewed Original ResearchConceptsSecure genome analysis competitionData retrieval queriesBlockchain-based methodData sharing methodReal-world problemsQuery indexType of sharingRetrieval queriesBlockchain technologyLedger technologySource codeBlockchain utilizationBlockchain strategyHealthcare applicationsInteraction recordsSharing methodTest datasetSharing recordsBiomedical research applicationsConsortium resourcesNew platformPatient recordsBlockchainQueriesTechnology
2020
The anatomy of a distributed predictive modeling framework: online learning, blockchain network, and consensus algorithm
Kuo T. The anatomy of a distributed predictive modeling framework: online learning, blockchain network, and consensus algorithm. JAMIA Open 2020, 3: 201-208. PMID: 32734160, PMCID: PMC7382618, DOI: 10.1093/jamiaopen/ooaa017.Peer-Reviewed Original ResearchBlockchain-based approachOnline machine learningSoftware development perspectiveProtect patient dataPrivacy technologiesBlockchain networkProgramming languageBlockchain technologyAlgorithmic objectivityImplementation detailsNon-determinismMachine learningSystem architectureBlockchainPatient dataDevelopment configurationAlgorithmTechnical componentsOnline learningSoftwareLearningTechnologyDesign detailsImplementationPrediction modelEXpectation Propagation LOgistic REgRession on permissioned blockCHAIN (ExplorerChain): decentralized online healthcare/genomics predictive model learning
Kuo T, Gabriel R, Cidambi K, Ohno-Machado L. EXpectation Propagation LOgistic REgRession on permissioned blockCHAIN (ExplorerChain): decentralized online healthcare/genomics predictive model learning. Journal Of The American Medical Informatics Association 2020, 27: 747-756. PMID: 32364235, PMCID: PMC7309256, DOI: 10.1093/jamia/ocaa023.Peer-Reviewed Original ResearchConceptsBlockchain technologyCentral serverServer-based methodBenefits of blockchainData protection policiesCentralized serverArtificial intelligenceModel learningDecentralized approachSmall datasetsBlockchainServerComputation strategySingle pointGeneralizable modelCost of efficiencyGenomic datasetsDatasetDistributed modelTechnologyGenomic dataMultiple institutionsDiscrimination powerIntelligencePotential advantages/disadvantagesComparison of Smart Contract Blockchains for Healthcare Applications.
Yu H, Sun H, Wu D, Kuo T. Comparison of Smart Contract Blockchains for Healthcare Applications. AMIA Annual Symposium Proceedings 2020, 2019: 1266-1275. PMID: 32308924, PMCID: PMC7153130.Peer-Reviewed Original ResearchConceptsHealthcare applicationsSmart contract blockchainHyperledger FabricBlockchain networkHealthcare blockchainHealthcare domainSmart contractsBlockchain technologyBlockchainFeatures of platformsPlatformHyperledgerEthereumImplementationTechnologyApplicationsNetworkHealthcareTutorialPragmatic comparison
2019
‘Fit-for-purpose?’ – challenges and opportunities for applications of blockchain technology in the future of healthcare
Mackey T, Kuo T, Gummadi B, Clauson K, Church G, Grishin D, Obbad K, Barkovich R, Palombini M. ‘Fit-for-purpose?’ – challenges and opportunities for applications of blockchain technology in the future of healthcare. BMC Medicine 2019, 17: 68. PMID: 30914045, PMCID: PMC6436239, DOI: 10.1186/s12916-019-1296-7.Peer-Reviewed Original ResearchConceptsApplication of blockchain technologyHealthcare-related dataBlockchain approachBusiness processesHealth blockchainBlockchain technologyData architectureBlockchainData managementTransform healthcareMultidisciplinary groups of practitionersImprove patient outcomesHealthcare stakeholdersHealthcare needsGroup of practitionersHealth sectorMultidisciplinary groupDesign elementsDataHealthcarePatient outcomesPerspective of consumersTechnologyEnhance complianceLow costComparison of blockchain platforms: a systematic review and healthcare examples
Kuo T, Rojas H, Ohno-Machado L. Comparison of blockchain platforms: a systematic review and healthcare examples. Journal Of The American Medical Informatics Association 2019, 26: 462-478. PMID: 30907419, PMCID: PMC7787359, DOI: 10.1093/jamia/ocy185.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBlockchain platformPopular blockchain platformsBlockchain applicationsSuitable blockchain platformDifferent blockchain platformsClinical informatics researchersTechnical featuresSoftware engineersHealth informatics applicationsHealthcare applicationsInformatics applicationsHealthcare exampleInformatics researchersPlatformBiomedical research applicationsHealthcareBlockchainImportant technical featuresKey featuresApplicationsResearch applicationsFeaturesBrief introductionTechnologyRequirements
2017
Blockchain distributed ledger technologies for biomedical and health care applications
Kuo T, Kim H, Ohno-Machado L. Blockchain distributed ledger technologies for biomedical and health care applications. Journal Of The American Medical Informatics Association 2017, 24: 1211-1220. PMID: 29016974, PMCID: PMC6080687, DOI: 10.1093/jamia/ocx068.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHealth care domainHealth care applicationsBlockchain technologyLedger technologyCare domainFeatures of blockchainBenefits of blockchainCare applicationsFamous BitcoinInformatics researchersBlockchainTechnologyApplicationsCovered topicsBitcoinDomainLatest applicationsPotential challengesDatabase