2006
Use of transgenic mice in acid-base balance studies.
Cantone A, Wang T, Pica A, Simeoni M, Capasso G. Use of transgenic mice in acid-base balance studies. Journal Of Nephrology 2006, 19 Suppl 9: s121-7. PMID: 16736435.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAcid-Base ImbalanceAnimalsCation Transport ProteinsDisease Models, AnimalDNAGene ExpressionKidney TubulesMembrane ProteinsMiceMice, TransgenicNitric Oxide SynthaseSodium-Bicarbonate SymportersSodium-Hydrogen Exchanger 1Sodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersConceptsAcid-base statusNitric oxide synthaseTransgenic miceMedullary thick ascending limbProximal tubule transportThick ascending limbSubunit expression levelsPotassium-chloride cotransporterKnockout animal modelsAcid-base balanceKidney regulationTransepithelial HCO3- absorptionNatriuretic responseBlood pressureRenal diseaseOxide synthaseDistal nephronAnimal modelsEndothelial isoformTubule transportBasolateral NHE1Proximal tubulesFunction of pendrinAscending limbHCO3- absorption
2000
Defective fluid and HCO3 − absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice
Wang T, Inglis F, Kalb R. Defective fluid and HCO3 − absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice. American Journal Of Physiology. Renal Physiology 2000, 279: f518-f524. PMID: 10966931, DOI: 10.1152/ajprenal.2000.279.3.f518.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAnimalsBicarbonatesBiological TransportBlood Gas AnalysisBody FluidsElectrolytesEnzyme InhibitorsInjections, IntravenousKidney Tubules, ProximalMiceMice, Inbred C57BLMice, KnockoutNG-Nitroarginine Methyl EsterNitric Oxide SynthaseNitric Oxide Synthase Type IPotassiumSodiumConceptsWild-type miceNNOS knockout miceL-NAMEProximal tubulesBlood pressureMetabolic acidosisNeuronal nitric oxide synthase knockout miceNitric oxide synthase knockout miceAbsorption of fluidFluid absorptionNeuronal nitric oxide synthaseRenal clearance techniquesMean blood pressureSignificant metabolic acidosisSynthase knockout miceMonomethyl-L-arginine methyl esterNitric oxide synthaseWild-type control animalsProximal tubule transportLuminal perfusion solutionAcid-base balanceIntravenous bolusUrinary excretionUrine volumeClearance technique
1994
Acidification in mammalian cortical distal tubule
Capasso G, Malnic G, Wang T, Giebisch G. Acidification in mammalian cortical distal tubule. Kidney International 1994, 45: 1543-1554. PMID: 7933802, DOI: 10.1038/ki.1994.204.Peer-Reviewed Original Research
1993
Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule.
Wang T, Malnic G, Giebisch G, Chan Y. Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule. Journal Of Clinical Investigation 1993, 91: 2776-2784. PMID: 8390489, PMCID: PMC443344, DOI: 10.1172/jci116519.Peer-Reviewed Original ResearchConceptsLate distal tubuleEarly distal tubuleDistal tubulesBicarbonate absorptionTubule segmentsFluid absorptionBicarbonate transportLuminal bicarbonate concentrationNet bicarbonate transportRenal bicarbonate reabsorptionLow K dietDistal tubule segmentsBicarbonate concentrationK-ATPase inhibitorPmol/minK dietBicarbonate secretionMicroperfusion experimentsBicarbonate reabsorptionH-ATPaseTubulesBafilomycin A1High rateRatsATPase inhibitor