2020
Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype.
Guo X, Fu Y, Zhang Y, Wang T, Lu L, Luo X, Wang K, Huang J, Xie T, Zheng C, Yang K, Tong J, Zuo L, Kang L, Tan Y, Jiang K, Li CR, Luo X. Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype. 2020, 4 PMID: 34046650, PMCID: PMC8153461.Peer-Reviewed Original ResearchMajor psychiatric disordersGenome-wide association studiesL-type voltage-gated calcium channelsMajor depressive disorderMRNA expression regulationPsychiatric disordersTherapeutic targetBipolar disorderChronic mild stress (CMS) ratsHuman hippocampusExpression regulationDepressive endophenotypeType voltage-gated calcium channelsRole of venlafaxineVoltage-gated calcium channelsPotential therapeutic targetRisk genesSignificant mRNA expressionVenlafaxine treatmentDepressive disorderStress ratsDepressive symptomsIndependent cohortCalcium channelsMRNA expression
2019
The bidirectional causal relationships of insomnia with five major psychiatric disorders: A Mendelian randomization study
Gao X, Meng L, Ma K, Liang J, Wang H, Gao Q, Wang T. The bidirectional causal relationships of insomnia with five major psychiatric disorders: A Mendelian randomization study. European Psychiatry 2019, 60: 79-85. PMID: 31234011, DOI: 10.1016/j.eurpsy.2019.05.004.Peer-Reviewed Original ResearchConceptsMajor psychiatric disordersPsychiatric disordersBipolar disorderAssociation of insomniaMendelian randomization studyAutism spectrum disorderOdds ratioObservational studySpectrum disorderInsomniaRandomization studyEffective interventionsCausal relationshipEgger regressionDisordersDisease modelsCausal roleMendelian randomizationConvincing evidenceGenome-wide association studiesAssociation