2024
Integrating Drug Target Information in Deep Learning Models to Predict the Risk of Adverse Events in Patients with Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder
Miranda O, Qi X, Brannock M, Whitworth R, Kosten T, Ryan N, Haas G, Kirisci L, Wang L. Integrating Drug Target Information in Deep Learning Models to Predict the Risk of Adverse Events in Patients with Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder. Biomedicines 2024, 12: 2772. DOI: 10.3390/biomedicines12122772.Peer-Reviewed Original ResearchPost-traumatic stress disorderAlcohol use disorder patientsAlcohol use disorderComorbid post-traumatic stress disorderUse disorderOpioid use disorderStress disorderSuicidal behaviorPotential therapeutic medicationsDeep learning modelsTarget informationDisordersElectronic medical recordsLearning modelsDepressionPotential therapeutic effectsNeighborhood-level social determinants of healthUniversity of Pittsburgh Medical CenterRisk of adverse eventsNeighborhood-level social determinantsSocial determinants of healthAdverse eventsMedicationAdverse outcomesDeterminants of health
2023
MicroRNA–mRNA networks are dysregulated in opioid use disorder postmortem brain: Further evidence for opioid-induced neurovascular alterations
Grimm S, Mendez E, Stertz L, Meyer T, Fries G, Gandhi T, Kanchi R, Selvaraj S, Teixeira A, Kosten T, Gunaratne P, Coarfa C, Walss-Bass C. MicroRNA–mRNA networks are dysregulated in opioid use disorder postmortem brain: Further evidence for opioid-induced neurovascular alterations. Frontiers In Psychiatry 2023, 13: 1025346. PMID: 36713930, PMCID: PMC9878702, DOI: 10.3389/fpsyt.2022.1025346.Peer-Reviewed Original ResearchOpioid use disorderUse disorderPostmortem brainsDorsolateral prefrontal cortexResponses to opioid drugsGenotype-Tissue ExpressionImmune system alterationsPrefrontal cortexNeurobiological alterationsBlood-brain barrierMiRNA targetsEpigenetic regulation of gene functionOpioid drugsRegulation of gene functionOpioid abuseTGF-betaGene signatureInflammatory pathwaysPotential functional impactSystem alterationsImmune systemBrain transcriptomeEndothelial cellsNeurovascular alterationsPostmortem samples