2024
APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart disease
2022
0321 Poor Agreement Among Self-Reported and Objective Sleep Deficiency Assessments in Older Persons
Miner B, Yaggi H, Gill T, Doyle M, Stone K, Redline S, Ensrud K, Blackwell T, Knauert M. 0321 Poor Agreement Among Self-Reported and Objective Sleep Deficiency Assessments in Older Persons. Sleep 2022, 45: a144-a145. DOI: 10.1093/sleep/zsac079.319.Peer-Reviewed Original ResearchInsufficient sleep durationSleep QuestionnaireSleep deficiencySleep durationAttention/alertnessOsteoporotic fracturesClaude D. Pepper Older Americans Independence CenterOlder personsNormal scoresSleep-disordered breathingAge-related decreaseAtypical presentationAverage ageNormal rangeSymptom awarenessOlder menSleep deficitsAmerican AcademySecondary analysisYoung populationSubstantial proportionNational InstituteWomenMenPoor sensitivity
2016
Effect of Structured Physical Activity on Overall Burden and Transitions Between States of Major Mobility Disability in Older Persons: Secondary Analysis of a Randomized Trial.
Gill TM, Guralnik JM, Pahor M, Church T, Fielding RA, King AC, Marsh AP, Newman AB, Pellegrini CA, Chen SH, Allore HG, Miller ME. Effect of Structured Physical Activity on Overall Burden and Transitions Between States of Major Mobility Disability in Older Persons: Secondary Analysis of a Randomized Trial. Annals Of Internal Medicine 2016, 165: 833-840. PMID: 27669457, PMCID: PMC5476905, DOI: 10.7326/m16-0529.Peer-Reviewed Original ResearchConceptsMajor mobility disabilityStructured physical activity programPhysical activity programPhysical activityMobility disabilityHealth educationActivity programStructured physical activityHealth education interventionNational InstituteOnset of disabilityQuality of lifeDisability episodeTreat principleRandomized trialsPatient assessmentRisk ratioOverall burdenProportion of assessmentsSedentary personsFunctional limitationsU.S. CentersEnhanced recoverySecondary analysisOlder persons