2023
Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses
Renedo D, Acosta J, Koo A, Rivier C, Sujijantarat N, de Havenon A, Sharma R, Gill T, Sheth K, Falcone G, Matouk C. Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses. Stroke 2023, 54: 1538-1547. PMID: 37216451, PMCID: PMC10212531, DOI: 10.1161/strokeaha.122.041891.Peer-Reviewed Original ResearchConceptsHospital Frailty Risk ScoreRisk of strokeHighest Hospital Frailty Risk ScoresDate of consentFrailty Risk ScoreMendelian randomization analysisStroke riskRisk scoreRandomization analysisTime of enrollmentAvailable electronic health recordsMendelian randomizationElectronic health recordsLook-back periodIncident strokeDose-response wayFrailty statusHemorrhagic strokeMultivariable analysisStroke eventsObservational studyHigh riskFrailtySignificant associationSimilar associationA genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways
Ye Y, Noche R, Szejko N, Both C, Acosta J, Leasure A, Brown S, Sheth K, Gill T, Zhao H, Falcone G. A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways. GeroScience 2023, 45: 2511-2523. PMID: 36928559, PMCID: PMC10651618, DOI: 10.1007/s11357-023-00771-z.Peer-Reviewed Original ResearchConceptsFried frailty scoreBiology of frailtyEuropean descent participantsOccurrence of frailtyGenome-wide association studiesMendelian randomization analysisFrailty scoreChronic painJoint disordersPolygenic risk scoresRespiratory diseaseInflammation pathwaysRisk scoreClinical phenotypeBrain tissueCausal associationFrailtyAge-related pathwaysRandomization analysisGenetic factorsAssociation studiesUK BiobankRetirement StudyPerson's vulnerabilitySignificant genetic correlations
2017
ASSOCIATIONS WITH POST-DISCHARGE FUNCTION OF OLDER ICU SURVIVORS: SENSITIVITY TO DEATH
Murphy T, Pisani M, Ferrante L, Gill T. ASSOCIATIONS WITH POST-DISCHARGE FUNCTION OF OLDER ICU SURVIVORS: SENSITIVITY TO DEATH. Innovation In Aging 2017, 1: 19-19. PMCID: PMC6241429, DOI: 10.1093/geroni/igx004.070.Peer-Reviewed Original ResearchAge 70 yearsPrecipitating Events ProjectOccurrence of deathSkilled nursing facilitiesICU admissionICU survivorsFunctional recoveryRisk factorsNursing facilitiesSelf-reported dependenceNon-disabled personsDeathFrailtyPrimary associationIADLsAssociationMobility measuresSurvivorsFocused examinationTotal countAdmissionYearsADLADLsDecedents
2010
Change in Disability After Hospitalization or Restricted Activity in Older Persons
Gill TM, Allore HG, Gahbauer EA, Murphy TE. Change in Disability After Hospitalization or Restricted Activity in Older Persons. JAMA 2010, 304: 1919-1928. PMID: 21045098, PMCID: PMC3124926, DOI: 10.1001/jama.2010.1568.Peer-Reviewed Original ResearchConceptsHazard ratioPhysical frailtySevere disabilityOlder personsMild disabilityMultivariable hazard ratiosProspective cohort studyCommunity-living personsFall-related injuriesGreater New HavenState of disabilityLikelihood of recoveryCohort studyAbsolute riskFrail individualsHospitalizationDaily livingNonfrail individualsRestricted activityInjuryTelephone interviewsFrailtyIllnessMonthsDisabilityTrajectories of Disability in the Last Year of Life
Gill TM, Gahbauer EA, Han L, Allore HG. Trajectories of Disability in the Last Year of Life. New England Journal Of Medicine 2010, 362: 1173-1180. PMID: 20357280, PMCID: PMC2877372, DOI: 10.1056/nejmoa0909087.Peer-Reviewed Original ResearchConceptsCourse of disabilityDisability trajectoriesOrgan failureAdvanced dementiaSudden deathOlder personsSevere disabilityCommunity-dwelling older personsTrajectories of disabilityLevel of disabilityCatastrophic disabilityEnd of lifeProgressive disabilityFunctional statusDeath certificatesCommon conditionBaseline assessmentPredominant trajectoriesMonthly interviewsDeathDisabilityLongitudinal studyDementiaFrailtyDecedents
2004
Hospitalization, Restricted Activity, and the Development of Disability Among Older Persons
Gill TM, Allore HG, Holford TR, Guo Z. Hospitalization, Restricted Activity, and the Development of Disability Among Older Persons. JAMA 2004, 292: 2115-2124. PMID: 15523072, DOI: 10.1001/jama.292.17.2115.Peer-Reviewed Original ResearchConceptsDevelopment of disabilityPhysical frailtyRestricted activityDaily livingOlder personsProspective cohort studyMonthly telephone interviewsMonths of hospitalizationPopulation attributable fractionGreater New HavenPrevention of disabilityOccurrence of disabilityCohort studyFrail participantsHospital admissionNonfrail participantsMultivariable hazardMAIN OUTCOMEDisabling processHospitalizationTelephone interviewsDisability onsetGeneral communityOlder adultsFrailty
2001
Two Recruitment Strategies for a Clinical Trial of Physically Frail Community‐Living Older Persons
Gill T, McGloin J, Gahbauer E, Shepard D, Bianco L. Two Recruitment Strategies for a Clinical Trial of Physically Frail Community‐Living Older Persons. Journal Of The American Geriatrics Society 2001, 49: 1039-1045. PMID: 11555064, DOI: 10.1046/j.1532-5415.2001.49206.x.Peer-Reviewed Original ResearchConceptsOffice-based strategiesCommunity-living personsPrimary care physiciansPhysical frailtyNumber of personsCare physiciansClinical trialsAge 75Older personsRefusal rateRecruitment strategiesSlow gait speedLower extremity functionPotential participantsQuadriceps weaknessRandomized participantsOffice visitsGait speedMean ageFrail communityFrailtyPatient rosterGeneral communityPhysiciansTrials