2010
Elevated Functional Connectivity Along a Corticostriatal Loop and the Mechanism of Auditory/Verbal Hallucinations in Patients with Schizophrenia
Hoffman RE, Fernandez T, Pittman B, Hampson M. Elevated Functional Connectivity Along a Corticostriatal Loop and the Mechanism of Auditory/Verbal Hallucinations in Patients with Schizophrenia. Biological Psychiatry 2010, 69: 407-414. PMID: 21145042, PMCID: PMC3039042, DOI: 10.1016/j.biopsych.2010.09.050.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsAntipsychotic AgentsCerebral CortexDiagnostic and Statistical Manual of Mental DisordersFemaleFrontal LobeHallucinationsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeostriatumNeural PathwaysNeuropsychological TestsPutamenSchizophreniaSchizophrenic PsychologySocioeconomic FactorsTemporal LobeVerbal BehaviorConceptsHealthy control subjectsControl subjectsFunctional connectivityNonhallucinating patientsPatient groupInferior frontal gyrusAuditory/verbal hallucinationsCorticostriatal loopsElevated functional connectivityVerbal hallucinationsFalse discovery rate correctionFunctional magnetic resonancePatientsSubcortical regionsLeft inferior frontal gyrusSeed regionPutamenFrontal gyrusSpeech processing networkFunctional coordinationNeural activitySchizophreniaFC relativeHigh levelsHallucinations
1999
Childhood-onset schizophrenia: progressive brain changes during adolescence
Giedd J, Jeffries N, Blumenthal J, Castellanos FX, Vaituzis A, Fernandez T, Hamburger S, Liu H, Nelson J, Bedwell J, Tran L, Lenane M, Nicolson R, Rapoport J. Childhood-onset schizophrenia: progressive brain changes during adolescence. Biological Psychiatry 1999, 46: 892-898. PMID: 10509172, DOI: 10.1016/s0006-3223(99)00072-4.Peer-Reviewed Original ResearchConceptsBrain anomaliesVentricular volumeTotal cerebrumLateral ventricleCOS groupDuration of illnessProgressive brain changesBrain magnetic resonanceStructural brain anomaliesBrain MRI studiesGender-matched controlsMean age 14Age-related changesAdult patientsAdult schizophreniaBrain changesMRI studiesControl groupLarger sample sizeBrain tissueBrain developmentHippocampusProgressionDiagnostic group differencesEarly adulthoodProgressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study
Rapoport JL, Giedd JN, Blumenthal J, Hamburger S, Jeffries N, Fernandez T, Nicolson R, Bedwell J, Lenane M, Zijdenbos A, Paus T, Evans A. Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study. JAMA Psychiatry 1999, 56: 649-654. PMID: 10401513, DOI: 10.1001/archpsyc.56.7.649.Peer-Reviewed Original ResearchConceptsChildhood-onset schizophreniaCortical gray matter volumeWhite matter volumeDisease-specific patternsGray matter volumeMatter volumeHealthy controlsCortical changesBrain tissueGray matterSchizophrenia groupLongitudinal magnetic resonance imaging studyBrain developmentBrain ventricular enlargementProgressive cortical changesMagnetic resonance imaging studyBrain magnetic resonanceEarly-onset schizophreniaTemporal gray matterAbnormal brain developmentResonance imaging studyVentricular enlargementMean ageOnset schizophreniaPatient's illness