2018
Chapter 49 Genetic susceptibility in obsessive-compulsive disorder
Fernandez TV, Leckman JF, Pittenger C. Chapter 49 Genetic susceptibility in obsessive-compulsive disorder. Handbook Of Clinical Neurology 2018, 148: 767-781. PMID: 29478613, DOI: 10.1016/b978-0-444-64076-5.00049-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObsessive-compulsive disorderPotential novel therapeutic avenuesNovel therapeutic avenuesSpecific risk allelesUnderlying pathophysiologyLarge cohortLifelong disabilityImmune pathwaysTherapeutic avenuesNew treatmentsGenetic susceptibilityRisk allelesCandidate gene association studiesMouse knockout modelsGenetic findingsGene association studiesKnockout modelsOCD pathologyRisk variantsNotable inroadsGenetic variantsDisordersVulnerable pathwaysSubstantial genetic contributionRepetitive behaviors
2013
Chapter Six Genetic Susceptibility and Neurotransmitters in Tourette Syndrome
Paschou P, Fernandez TV, Sharp F, Heiman GA, Hoekstra PJ. Chapter Six Genetic Susceptibility and Neurotransmitters in Tourette Syndrome. International Review Of Neurobiology 2013, 112: 155-177. PMID: 24295621, PMCID: PMC4471172, DOI: 10.1016/b978-0-12-411546-0.00006-8.ChaptersConceptsGene expression findingsExpression findingsEtiology of TSGenetic workTwo-generation pedigreeTs phenotypeMolecular baseGenetic contributionTourette syndromeLikely interactionsMultifactorial inheritanceSegregation studiesNeurotransmitter systemsAutosomal dominant disorderGenetic factorsDynamic interplayGenetic susceptibilityNew treatment optionsExtracellular dopamine levelsGamma-aminobutyric acidDominant disorderGenesTreatment optionsCortico-striatoDopamine levels