2021
Evaluation Within 30 Days of Referral for Liver Transplantation is Associated with Reduced Mortality: A Multicenter Analysis of Patients Referred Within the VA Health System
John BV, Schwartz K, Scheinberg AR, Dahman B, Spector S, Deng Y, Goldberg D, Martin P, Taddei TH, Kaplan DE. Evaluation Within 30 Days of Referral for Liver Transplantation is Associated with Reduced Mortality: A Multicenter Analysis of Patients Referred Within the VA Health System. Transplantation 2021, 106: 72-84. PMID: 33587434, PMCID: PMC8239056, DOI: 10.1097/tp.0000000000003615.Peer-Reviewed Original ResearchConceptsLiver transplantationTransplant centersPretransplant mortalityMultivariable Cox hazard modelTransplant evaluation processSuccessful liver transplantationMulticenter retrospective studyEvaluation of patientsVA health systemDays of referralCox hazard modelPosttransplant deathTransplant evaluationPosttransplant mortalityHigher MELDMulticenter analysisRetrospective studyList dropoutReduced mortalityHazards modelPatientsTransplantationReferralHealth systemMortalityFactors Associated With Access to and Receipt of Liver Transplantation in Veterans With End-stage Liver Disease
Kanwal F, Hernaez R, Liu Y, Taylor TJ, Rana A, Kramer JR, Naik AD, Smith D, Taddei T, Asch SM. Factors Associated With Access to and Receipt of Liver Transplantation in Veterans With End-stage Liver Disease. JAMA Internal Medicine 2021, 181: 949-959. PMID: 34028505, PMCID: PMC8145153, DOI: 10.1001/jamainternmed.2021.2051.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseAdvanced liver diseaseLiver diseaseLiver transplantationCohort studyMedical recordsOrgan transplantsVeterans Affairs Health Care SystemLower ratesRetrospective cohort studyWait-listed patientsAfrican American patientsComprehensive electronic medical recordsElectronic medical recordsHealth care systemReferral stepsLiver allograftsLiver transplantAdult patientsAlcohol etiologyLow annual incomePatient ageCurative therapyLiver cirrhosisSodium score
2020
Palliative Care in Cirrhosis: Beyond Misconceptions
Jakab S, Verma M, Navarro V, Taddei T. Palliative Care in Cirrhosis: Beyond Misconceptions. Current Treatment Options In Gastroenterology 2020, 18: 245-254. DOI: 10.1007/s11938-020-00283-1.Peer-Reviewed Original ResearchAdvanced liver diseasePalliative careLiver diseaseManagement of patientsDifferent patient populationsQuality of lifeLiver transplantationSupportive carePatient populationLiver cancerPractical updateMedical providersRoutine practicePatientsCareCirrhosisDelivery modeBest delivery modeDiseaseCaregiversTransplantationHepatologyClarification of goalsSymptomsCancerSurvival Benefit of Liver Transplantation for Hepatocellular Carcinoma.
Kanneganti M, Mahmud N, Kaplan DE, Taddei TH, Goldberg DS. Survival Benefit of Liver Transplantation for Hepatocellular Carcinoma. Transplantation 2020, 104: 104-112. PMID: 31283688, PMCID: PMC6928443, DOI: 10.1097/tp.0000000000002816.Peer-Reviewed Original ResearchConceptsIncremental survival benefitLiver transplantSurvival benefitHepatocellular carcinomaEnd-stage liver disease (MELD) scoreOverall long-term survivalIntermediate-stage hepatocellular carcinomaLiver Disease scoreRetrospective cohort studyStage hepatocellular carcinomaHazard of deathVeterans Health AdministrationImmortal time biasLong-term survivalUnderwent resectionLiver transplantationAnalytic cohortCohort studyCurative optionMultivariable modelHCC diagnosisDisease scoreResectionPatientsHealth Administration
2019
Pre‐transplant alpha‐fetoprotein is associated with post‐transplant hepatocellular carcinoma recurrence mortality
Mahmud N, John B, Taddei T, Goldberg DS. Pre‐transplant alpha‐fetoprotein is associated with post‐transplant hepatocellular carcinoma recurrence mortality. Clinical Transplantation 2019, 33: e13634. PMID: 31177570, PMCID: PMC6635076, DOI: 10.1111/ctr.13634.Peer-Reviewed Original ResearchConceptsHCC recurrenceLiver transplantationAlpha-fetoproteinHepatocellular carcinomaLiver diseaseHepatitis C liver diseaseEnd-stage liver diseaseC liver diseasePre-transplant modelRetrospective cohort studyOrgan Sharing databaseAdult transplant recipientsCox regression analysisTransplant recipientsCohort studySharing databaseMedian timeAFP levelsCox regressionPatient survivalUnited NetworkPoor survivalHigh riskRecurrencePatients
2017
Healthcare Costs Related to Treatment of Hepatocellular Carcinoma Among Veterans With Cirrhosis in the United States
Kaplan DE, Chapko MK, Mehta R, Dai F, Skanderson M, Aytaman A, Baytarian M, D’Addeo K, Fox R, Hunt K, Pocha C, Valderrama A, Taddei TH, Group V. Healthcare Costs Related to Treatment of Hepatocellular Carcinoma Among Veterans With Cirrhosis in the United States. Clinical Gastroenterology And Hepatology 2017, 16: 106-114.e5. PMID: 28756056, PMCID: PMC5735018, DOI: 10.1016/j.cgh.2017.07.024.Peer-Reviewed Original ResearchConceptsMultivariable generalized linear modelsMultidisciplinary tumor boardHepatocellular carcinomaIntegrated health systemCancer-related costsHealthcare costsLiver transplantationBCLC stageLiver diseaseTumor boardBarcelona Clinic Liver Cancer stageVeterans Affairs Corporate Data WarehouseHealth systemCases of HCCBasis of receiptLiver disease cohortReceipt of transplantationLiver disease etiologyChronic liver diseaseLiver Cancer stageLiver cancer surveillanceBasis of severityHospital academic affiliationCorporate Data WarehouseCirrhosis controlsAssociation of Provider Specialty and Multidisciplinary Care With Hepatocellular Carcinoma Treatment and Mortality
Serper M, Taddei TH, Mehta R, D’Addeo K, Dai F, Aytaman A, Baytarian M, Fox R, Hunt K, Goldberg DS, Valderrama A, Kaplan DE, Group V. Association of Provider Specialty and Multidisciplinary Care With Hepatocellular Carcinoma Treatment and Mortality. Gastroenterology 2017, 152: 1954-1964. PMID: 28283421, PMCID: PMC5664153, DOI: 10.1053/j.gastro.2017.02.040.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, HepatocellularChi-Square DistributionDelivery of Health Care, IntegratedFemaleGastroenterologistsHumansKaplan-Meier EstimateLiver NeoplasmsLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioOncologistsPatient Care TeamPractice Patterns, Physicians'Proportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsSpecializationSurgeonsTime FactorsTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsRetrospective cohort studyMultidisciplinary tumor boardHealth system factorsHepatocellular carcinomaHCC therapyCohort studyOverall survivalTumor boardTime-varying Cox proportional hazards modelsCox proportional hazards modelActive hepatocellular carcinomaOutcomes of patientsProportional hazards modelHepatocellular carcinoma treatmentVeterans Administration HospitalSystem factorsLiver transplantationActive therapyLiver resectionTransarterial therapiesMedical oncologistsMultidisciplinary careSubspecialist carePatient survivalAblative therapy
2015
Therapeutic Strategies for Hepatocellular Carcinoma: New Advances and Challenges
Vilarinho S, Taddei T. Therapeutic Strategies for Hepatocellular Carcinoma: New Advances and Challenges. Current Treatment Options In Gastroenterology 2015, 13: 219-234. PMID: 25791207, DOI: 10.1007/s11938-015-0049-8.BooksLiver transplantationSurgical resectionTherapeutic modalitiesContrast-enhanced computerized tomographyBi-lobar diseaseDecompensated liver diseaseOpinion statementHepatocellular carcinomaPortal venous washoutCatheter-directed therapyCurative surgical resectionGood performance statusLiver synthetic functionYttrium-90 microspheresPortal vein occlusionExtra-hepatic metastasisNon-cirrhotic liverHigh-risk individualsInternal radiation therapyMultiple therapeutic modalitiesDiagnosis of HCCMagnetic resonance imagingLevel of suspicionCurative ablationUnresectable diseaseVenous washout
2013
Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography
Bari K, Aslanian HR, Pollak J, Reiner E, Salem RR, Taddei TH, Emre SH, Jamidar PA. Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography. ACG Case Reports Journal 2013, 1: 51-54. PMID: 26157820, PMCID: PMC4435262, DOI: 10.14309/crj.2013.18.Peer-Reviewed Case Reports and Technical NotesEndoscopic retrograde cholangiopancreatographySecondary biliary cirrhosisEmphysematous cholecystitisBiliary cirrhosisRare complicationRetrograde cholangiopancreatographyPercutaneous transhepatic biliary drainsAcute emphysematous cholecystitisBroad-spectrum antibioticsEvaluation of sphincterBiliary necrosisCholangitic abscessesLiver transplantationOddi dysfunctionBiliary obstructionPrompt diagnosisSurgical managementBiliary drainRecurrent episodesBiliary treeCholecystitisCirrhosisCholangiopancreatographyComplicationsClostridium perfringensLiver transplantation in the human immunodeficiency virus–hepatitis C virus coinfected patient: Time to sum up
Samuel D, Duclos-Vallee J, Groszmann R, Iwakiri Y, Taddei T. Liver transplantation in the human immunodeficiency virus–hepatitis C virus coinfected patient: Time to sum up. Hepatology 2013, 57: 409-411. PMID: 23297070, DOI: 10.1002/hep.26123.Peer-Reviewed Original ResearchCoinfected patientsLiver transplantation
2004
Impact of body mass index on graft failure and overall survival following liver transplant*
Rustgi VK, Marino G, Rustgi S, Halpern MT, Johnson LB, Tolleris C, Taddei TH. Impact of body mass index on graft failure and overall survival following liver transplant*. Clinical Transplantation 2004, 18: 634-637. PMID: 15516235, DOI: 10.1111/j.1399-0012.2004.00141.x.Peer-Reviewed Original ResearchConceptsElevated body mass indexBody mass indexLower body mass indexLikelihood of deathMass indexLiver transplantLiver transplantationGraft failureImpact of BMIHigher body mass indexGraft failure rateNumber of comorbiditiesOrgan Sharing databaseOverall survival rateProportional hazards regressionRisk of deathOverall survivalSharing databaseHazards regressionUnited NetworkRisk factorsBMI valuesPatientsSurvival rateDecreased likelihood