A systematic review in effects of glucagon-like peptide-1 (GLP-1) mono-agonists on functional connectivity: Target engagement and rationale for the development in mental disorders
Au H, Zheng Y, Le G, Wong S, Phan L, Teopiz K, Kwan A, Rhee T, Rosenblat J, Ho R, McIntyre R. A systematic review in effects of glucagon-like peptide-1 (GLP-1) mono-agonists on functional connectivity: Target engagement and rationale for the development in mental disorders. Journal Of Affective Disorders 2024, 370: 321-327. PMID: 39515485, DOI: 10.1016/j.jad.2024.11.019.Peer-Reviewed Original ResearchDorsal default mode networkFunctional connectivityMental disordersAssociated with decreased functional connectivityAssociated with increased functional connectivityRight frontal-parietal networkLateral orbitofrontal cortexFrontal-parietal networkDefault mode networkIncreased functional connectivityBrain functional connectivityBrain functional activityGlucagon-like peptide-1Orbitofrontal cortexPsychopathological domainsSalience networkVisuospatial networkMode networkParietal networkPsychiatric disordersBrain circuitsNeural circuitsGLP-1RAsGlucagon-like peptide-1 receptor activationReceptor agonistsAssociation between cognitive functioning, suicidal ideation and suicide attempts in major depressive disorder, bipolar disorder, schizophrenia and related disorders: A systematic review and meta-analysis
Le G, Wong S, Haikazian S, Johnson D, Badulescu S, Kwan A, Gill H, Di Vincenzo J, Rosenblat J, Mansur R, Teopiz K, Rhee T, Ho R, Liao S, Cao B, Schweinfurth-Keck N, Vinberg M, Grande I, Phan L, d'Andrea G, McIntyre R. Association between cognitive functioning, suicidal ideation and suicide attempts in major depressive disorder, bipolar disorder, schizophrenia and related disorders: A systematic review and meta-analysis. Journal Of Affective Disorders 2024, 365: 381-399. PMID: 39168166, DOI: 10.1016/j.jad.2024.08.057.Peer-Reviewed Original ResearchBipolar disorderCognitive functionSchizoaffective disorderDepressive disorderExecutive functionMental disordersMeasures of cognitive functionSelf-injurious behaviorTreatable mental disorderGlobal executive functioningEffect size of associationSuicidal ideation/suicide attemptTransdiagnostic associationsSize of associationEmotional inhibitionWorking memoryNegative associationCognitive measuresNeurocognitive deficitsSuicidal ideationSuicide riskCognitive disturbancesImpulse controlProcessing speedMDD