2021
Improving the leptospirosis disease burden assessment by including ambulatory patients from outpatient departments: a cross-sectional study
Warnasekara J, Aberathna P, Nanayakkara G, Vinetz J, Agampodi S. Improving the leptospirosis disease burden assessment by including ambulatory patients from outpatient departments: a cross-sectional study. F1000Research 2021, 9: 1129. PMID: 34123371, PMCID: PMC8145224, DOI: 10.12688/f1000research.26202.2.Peer-Reviewed Original ResearchConceptsOutpatient departmentOPD patientsAmbulatory patientsDisease burdenPrimary care centersProvincial General HospitalCases of leptospirosisCross-sectional studyDisease burden assessmentMicroscopic agglutination testPublic health implicationsQuantitative polymerase chain reactionOPD settingRegional Public HospitalOPD visitsLeptospirosis patientsFever patientsPatient numbersHospital inpatientsPolymerase chain reactionCare centerGeneral HospitalBurden assessmentPatientsSame period
2020
Improving the leptospirosis disease burden assessment by including ambulatory patients from outpatient departments: a cross-sectional study
Warnasekara J, Aberathna P, Nanayakkara G, Vinetz J, Agampodi S. Improving the leptospirosis disease burden assessment by including ambulatory patients from outpatient departments: a cross-sectional study. F1000Research 2020, 9: 1129. DOI: 10.12688/f1000research.26202.1.Peer-Reviewed Original ResearchOutpatient departmentDisease burden assessmentOPD patientsAmbulatory patientsBurden assessmentPrimary care centersProvincial General HospitalCases of leptospirosisCross-sectional studyPrevalence of leptospirosisMicroscopic agglutination testPublic health implicationsDisease burden estimationQuantitative polymerase chain reactionOPD settingRegional Public HospitalOPD visitsTreatable diagnosisLeptospirosis patientsFever patientsPatient numbersHospital inpatientsDisease burdenPolymerase chain reactionCare center
2016
Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka.
Agampodi SB, Dahanayaka NJ, Nöckler K, Mayer-Scholl A, Vinetz JM. Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka. American Journal Of Tropical Medicine And Hygiene 2016, 95: 531-536. PMID: 27402521, PMCID: PMC5014254, DOI: 10.4269/ajtmh.16-0033.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayMicroscopic agglutination testIgG enzyme-linked immunosorbent assayQuantitative polymerase chain reactionImmunoglobulin G (IgG) ELISAHouse enzyme-linked immunosorbent assayDays of illnessAcute-phase seraCases of leptospirosisAvailable enzyme-linked immunosorbent assayGold standard testingMAT positive samplesDiagnostic test resultsAcute specimensAcute phasePatient populationPhase seraPolymerase chain reactionBlood samplesSerological sensitivityAgglutination testImmunosorbent assayLeptospirosisLeptospira kirschneriDominant serovars
2012
Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka
Agampodi SB, Matthias MA, Moreno AC, Vinetz JM. Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka. Clinical Infectious Diseases 2012, 54: 1249-1255. PMID: 22354922, PMCID: PMC3404689, DOI: 10.1093/cid/cis035.Peer-Reviewed Original ResearchConceptsQuantitative polymerase chain reactionClinical manifestationsPolymerase chain reactionBlood samplesChain reactionWhole bloodOnset of symptomsSensitivity of qPCRAssociation of levelsSerum/bloodMicroscopic agglutination test panelValid diagnostic testPatient blood samplesOptimal sample typeFailure patientsRenal failureWhole blood samplesPatient populationTimely diagnosisLeptospiral loadEndemic areasDay 2Day 15LeptospiremiaDiagnostic tests