2017
Factors associated with anemia among Sri Lankan primary school children in rural North Central Province
Amarasinghe GS, Naottunna NP, Agampodi TC, Agampodi SB. Factors associated with anemia among Sri Lankan primary school children in rural North Central Province. BMC Pediatrics 2017, 17: 87. PMID: 28347295, PMCID: PMC5369015, DOI: 10.1186/s12887-017-0841-9.Peer-Reviewed Original ResearchConceptsRural primary school childrenPrimary school childrenIron deficiencyFerritin levelsSerum ferritinMajor public health problemSchool childrenSerum ferritin levelsEarly iron deficiencyPublic health problemFrequency of meatExternal quality control measuresMonthly family incomeBlood film analysisSelf-administered questionnaireBlood reportsAnemic childrenMiddle-income countriesHemoglobin levelsChildhood anemiaIron storesPossible etiologiesAnthropometric measurementsBlood samplesAnemia
2016
Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka.
Agampodi SB, Dahanayaka NJ, Nöckler K, Mayer-Scholl A, Vinetz JM. Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka. American Journal Of Tropical Medicine And Hygiene 2016, 95: 531-536. PMID: 27402521, PMCID: PMC5014254, DOI: 10.4269/ajtmh.16-0033.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayMicroscopic agglutination testIgG enzyme-linked immunosorbent assayQuantitative polymerase chain reactionImmunoglobulin G (IgG) ELISAHouse enzyme-linked immunosorbent assayDays of illnessAcute-phase seraCases of leptospirosisAvailable enzyme-linked immunosorbent assayGold standard testingMAT positive samplesDiagnostic test resultsAcute specimensAcute phasePatient populationPhase seraPolymerase chain reactionBlood samplesSerological sensitivityAgglutination testImmunosorbent assayLeptospirosisLeptospira kirschneriDominant serovars
2012
Utility and Limitations of Direct Multi-Locus Sequence Typing on qPCR-Positive Blood to Determine Infecting Leptospira Strain
Agampodi SB, Moreno AC, Vinetz JM, Matthias MA. Utility and Limitations of Direct Multi-Locus Sequence Typing on qPCR-Positive Blood to Determine Infecting Leptospira Strain. American Journal Of Tropical Medicine And Hygiene 2012, 88: 184-185. PMID: 23208890, PMCID: PMC3541733, DOI: 10.4269/ajtmh.2012.12-0526.Peer-Reviewed Original ResearchConceptsPolymerase chain reaction-positive samplesBacterial loadLeptospira strainsMLST profilesAcute illnessBlood samplesHuman leptospirosisComplete MLST profilesCulture isolationMulti-locus sequenceHuman bloodSequence typesBloodCentral Sri LankaInterpretable dataMolecular characterizationIllnessLeptospirosisST44Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka
Agampodi SB, Matthias MA, Moreno AC, Vinetz JM. Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka. Clinical Infectious Diseases 2012, 54: 1249-1255. PMID: 22354922, PMCID: PMC3404689, DOI: 10.1093/cid/cis035.Peer-Reviewed Original ResearchConceptsQuantitative polymerase chain reactionClinical manifestationsPolymerase chain reactionBlood samplesChain reactionWhole bloodOnset of symptomsSensitivity of qPCRAssociation of levelsSerum/bloodMicroscopic agglutination test panelValid diagnostic testPatient blood samplesOptimal sample typeFailure patientsRenal failureWhole blood samplesPatient populationTimely diagnosisLeptospiral loadEndemic areasDay 2Day 15LeptospiremiaDiagnostic tests
2009
Evaluation of surveillance case definition in the diagnosis of leptospirosis, using the Microscopic Agglutination Test: a validation study
Dassanayake D, Wimalaratna H, Agampodi SB, Liyanapathirana VC, Piyarathna T, Goonapienuwala BL. Evaluation of surveillance case definition in the diagnosis of leptospirosis, using the Microscopic Agglutination Test: a validation study. BMC Infectious Diseases 2009, 9: 48. PMID: 19386085, PMCID: PMC2679753, DOI: 10.1186/1471-2334-9-48.Peer-Reviewed Original ResearchConceptsSurveillance case definitionMicroscopic agglutination testCase definitionNegative predictive valuePredictive valueClinical featuresMAT titresAgglutination testDays of feverAcute febrile illnessMethodsThe study populationTeaching Hospital KandyPositive predictive valueDiagnosis of leptospirosisPositive MAT resultsFebrile illnessMedical wardsResultsA totalHospital KandyStudy populationBlood samplesConclusionThis studyPatientsDiagnostic accuracyLeptospirosis