2008
Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis
Kim S, Kim J, Han J, Yoon Y. Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis. International Journal Of Toxicology 2008, 27: 175-182. PMID: 18404541, DOI: 10.1080/10915810801977906.Peer-Reviewed Original ResearchConceptsInterstitial Leydig cellsSteroidogenic enzymesLeydig cellsImmature male miceSerum testosterone concentrationsTesticular developmentInhibition of steroidogenesisCholesterol side-chain cleavage enzymeSide-chain cleavage enzymeSteroid hormone productionGerm cellsTesticular germ cellsApoptotic germ cellsOral gavageMale miceSingle administrationTestosterone concentrationsHormone productionInhibitory effectSeminiferous tubulesAdverse effectsInduced apoptosisTBT exposureAcute toxicityCleavage enzyme
2007
Comparative Analysis of the Developmental Competence of Three Human Embryonic Stem Cell Lines in Vitro
Kim S, Kim B, Gil J, Kim S, Kim J. Comparative Analysis of the Developmental Competence of Three Human Embryonic Stem Cell Lines in Vitro. Molecules And Cells 2007, 23: 49-56. PMID: 17464211, DOI: 10.1016/s1016-8478(23)07388-0.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsHESC linesHuman embryonic stem cell linesEmbryonic stem cell linesPrimordial germ cellsDevelopmental potentialEmbryonic stem cellsEmbryonic germ layersEmbryoid body formationSpecific cell typesDevelopmental competenceStem cell linesCell replacement therapyExtraembryonic tissuesStem cell technologyGerm layersTerminal differentiationGerm cellsBody formationPluripotency markersCell typesNeuronal cellsTelomerase activityStem cellsHSF6
2006
Involvement of the Fas–Fas ligand system and active caspase-3 in abnormal apoptosis in human testes with maturation arrest and Sertoli cell–only syndrome
Kim S, Yoon Y, Park Y, Seo J, Kim J. Involvement of the Fas–Fas ligand system and active caspase-3 in abnormal apoptosis in human testes with maturation arrest and Sertoli cell–only syndrome. Fertility And Sterility 2006, 87: 547-553. PMID: 17123522, DOI: 10.1016/j.fertnstert.2006.07.1524.Peer-Reviewed Original ResearchConceptsMaturation arrestActive caspase-3Sertoli cellsCaspase-3Testicular expressionDUTP nick end labeling stainingCases of SCOTerminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) stainingNick end labeling stainingTransferase-mediated dUTP nick-end labeling stainingTesticular biopsy specimensTestes of patientsGerm cellsTranscription-polymerase chain reactionFas-Fas ligand systemRoutine clinical purposesHyperplastic interstitial cellsExpression of FasLExpression of FasBiopsy specimensMAIN OUTCOMEObstructive azoospermiaImmunohistochemical analysisIntense immunostainingLabeling staining
2004
PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT
KIM S, LEE H, YANG H, KIM H, YOON Y. PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT. Systems Biology In Reproductive Medicine 2004, 50: 427-441. PMID: 15669608, DOI: 10.1080/01485010490475093.Peer-Reviewed Original ResearchConceptsTesticular germ cellsEstradiol valerateSerum LH concentrationsSerum testosterone concentrationsGerm cellsWeek old ratsPrepubertal male ratsLH concentrationsMale reproductive organsMale ratsTestosterone concentrationsAdult ratsOld ratsChronic exposureMarked reductionSeminiferous tubulesRatsSeminal vesiclesBcl-2Decreased biosynthesisBax mRNAThree timesTesticular developmentBcl-xL mRNAApoptosis