2012
Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells
Kuzmichev A, Kim S, D’Alessio A, Chenoweth J, Wittko I, Campanati L, McKay R. Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells. Current Biology 2012, 22: 1705-1710. PMID: 22902753, DOI: 10.1016/j.cub.2012.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCDX2 Transcription FactorCell DifferentiationCell LineColonic NeoplasmsFibroblastsGene Expression RegulationHomeodomain ProteinsIntestinal MucosaIntestinesMiceMice, TransgenicOctamer Transcription Factor-3Pluripotent Stem CellsSOXB1 Transcription FactorsSOXB2 Transcription FactorsTranscription FactorsTranscription, GeneticTranscriptional ActivationConceptsStem cellsImportant transcriptional regulatorStem cell renewalIntestinal stem cellsAdult stem cellsColon cancer cellsEndodermal identityPluripotent stem cellsEffect of SOX2Gene familyCell identityPluripotent stateTranscriptional partnersTranscriptional regulatorsTranscriptional inductionTranscription factorsMaster regulatorTranscriptional actionGene expressionSox21Differentiated cellsCell renewalSOX2General mediatorCell types
2007
Directed differentiation of human embryonic stem cells towards a pancreatic cell fate
Shim J, Kim S, Woo D, Kim S, Oh C, McKay R, Kim J. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 2007, 50: 1228-1238. PMID: 17457565, DOI: 10.1007/s00125-007-0634-z.Peer-Reviewed Original ResearchMeSH KeywordsActivinsAnimalsCell Culture TechniquesCell DifferentiationDiabetes Mellitus, ExperimentalEmbryonic Stem CellsGene Expression RegulationHomeodomain ProteinsHumansMaleMiceMice, Inbred BALB CMice, NudePancreasReverse Transcriptase Polymerase Chain ReactionStem Cell TransplantationTrans-ActivatorsTransplantation, HeterologousTretinoinConceptsHuman embryonic stem cellsPdx1-positive cellsForkhead box protein A2Embryonic stem cellsEndodermal cellsCaudal-type homeobox transcription factor 2Differentiation of hESCsCell typesPancreatic cell fateRetinoic acidStem cellsMature cell typesEmbryonic germ layersEmbryoid body formationPancreatic cell typesBox protein A2Transcription factor 2Vivo pancreatic developmentEpigenetic signalsCell fateEctodermal differentiationDuodenal homeobox 1Pancreatic fateGene 17Gene expression
2006
Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells
Kim B, Kim S, Shim J, Woo D, Gil J, Kim S, Kim J. Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells. FEBS Letters 2006, 580: 5869-5874. PMID: 17027979, DOI: 10.1016/j.febslet.2006.09.053.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsVascular endothelial growth factorGerm layer formationEmbryonic stem cellsEmbryoid bodiesEndothelial growth factorNeurogenic effectsGrowth factorStem cellsEffects of VEGFNeuroectodermal genesVascular endothelial cellsHESC differentiationNeural rosettesDopaminergic neuronsGene expressionNeural progenitorsTerminal differentiationVEGF treatmentPotent mitogenEndothelial cellsNeuroectodermal differentiationDifferentiationCellsExpression