2006
Nonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway
Kim S, Kim B, Shim J, Gil J, Yoon Y, Kim J. Nonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway. Toxicological Sciences 2006, 94: 310-321. PMID: 16984955, DOI: 10.1093/toxsci/kfl114.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsUndifferentiated hES cellsEmbryonic stem cellsHES cellsNeural progenitor cellsEarly embryonic developmentStem cellsProgenitor cellsToxic stress responseChemical-induced apoptosisFas ligand protein expressionFas-Fas ligand pathwayCell replacement therapyEmbryonic developmentCaspase activationES cellsCaspase-8Stress responseDevelopmental stagesDNA fragmentationCell typesFas-FasL interactionCommon environmental contaminantsApoptosisProtein expression
2004
PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT
KIM S, LEE H, YANG H, KIM H, YOON Y. PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT. Systems Biology In Reproductive Medicine 2004, 50: 427-441. PMID: 15669608, DOI: 10.1080/01485010490475093.Peer-Reviewed Original ResearchConceptsTesticular germ cellsEstradiol valerateSerum LH concentrationsSerum testosterone concentrationsGerm cellsWeek old ratsPrepubertal male ratsLH concentrationsMale reproductive organsMale ratsTestosterone concentrationsAdult ratsOld ratsChronic exposureMarked reductionSeminiferous tubulesRatsSeminal vesiclesBcl-2Decreased biosynthesisBax mRNAThree timesTesticular developmentBcl-xL mRNAApoptosis