2019
1382-P: Impaired Default Mode Network Suppression and Compensatory Hyperactivation in Children with Type 1 Diabetes
FOLAND-ROSS L, BUCKINGHAM B, MAURAS N, ARBELAEZ A, WHITE N, AYE T, WILSON D, TAMBORLANE W, WEINZIMER S, TSALIKIAN E, TANSEY M, CATO A, HERSHEY T, FOX L, TONG G, ENGLERT K, MAZAIKA P, REISS A. 1382-P: Impaired Default Mode Network Suppression and Compensatory Hyperactivation in Children with Type 1 Diabetes. Diabetes 2019, 68 DOI: 10.2337/db19-1382-p.Peer-Reviewed Original ResearchDefault mode networkExecutive control regionsDiabetes careMedtronic MiniMedSpouse/partnerGreater activationEunice Kennedy Shriver National InstituteLess suppressionEffects of dysglycemiaAdvisory PanelEli LillySimilar task performanceExecutive control areasParent-report measuresTakeda Pharmaceutical Company LimitedNondiabetic childrenT1D groupHbA1c levelsNondiabetic controlsSlower processing speedT1D onsetHigher HbA1cChild healthResearch supportMulti-site study
2013
Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
Marzelli MJ, Mazaika PK, Barnea-Goraly N, Hershey T, Tsalikian E, Tamborlane W, Mauras N, White NH, Buckingham B, Beck RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL, Network F. Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes. Diabetes 2013, 63: 343-353. PMID: 24170697, PMCID: PMC3868050, DOI: 10.2337/db13-0179.Peer-Reviewed Original ResearchConceptsGray matter volumeT1D groupControl subjectsWhole brain volumetric analysisAge-matched control subjectsEarly-onset T1DNeuroanatomical correlatesType 1 diabetesRegional brain volumesYoung childrenVoxel-based morphometryMedial prefrontal cortexGlycemic dysregulationGlycemic exposureTemporal-occipital regionsTemporal pole regionsStructural magnetic resonance imagesHyperglycemic exposureMatter volumeBrain volumeType 1Cerebellar regionsPrefrontal cortexBrain structuresMagnetic resonance images