2019
209-OR: ADA Presidents' Select Abstract: Type 1 Diabetes and the Developing Brain—A Longitudinal Study of Brain Growth by the Diabetes Research in Children Network (DirecNet)
ARBELAEZ A, O’DONOGHUE S, MAURAS N, BUCKINGHAM B, WHITE N, WEINZIMER S, AYE T, TSALIKIAN E, WILSON D, TAMBORLANE W, TANSEY M, CATO A, HERSHEY T, FOX L, ENGLERT K, REISS A. 209-OR: ADA Presidents' Select Abstract: Type 1 Diabetes and the Developing Brain—A Longitudinal Study of Brain Growth by the Diabetes Research in Children Network (DirecNet). Diabetes 2019, 68 DOI: 10.2337/db19-209-or.Peer-Reviewed Original ResearchDiabetes careNondiabetic controlsVoxel-based morphometryMedtronic MiniMedWhite matterSubcortical GMSpouse/partnerEarly-onset type 1 diabetesEunice Kennedy Shriver National InstituteAge-matched nondiabetic controlsEarly-onset T1DTime of diagnosisWorse glycemic controlType 1 diabetesEffects of T1DBasal ganglia regionsAdvisory PanelRapid brain maturationWhite matter areasEli LillyGray matter volumeGray matter regionsTakeda Pharmaceutical Company LimitedGlycemic exposureT1D children
2018
Longitudinal assessment of hippocampus structure in children with type 1 diabetes
Foland‐Ross L, Reiss AL, Mazaika PK, Mauras N, Weinzimer SA, Aye T, Tansey MJ, White NH, Network T. Longitudinal assessment of hippocampus structure in children with type 1 diabetes. Pediatric Diabetes 2018, 19: 1116-1123. PMID: 29675980, PMCID: PMC6195484, DOI: 10.1111/pedi.12683.Peer-Reviewed Original ResearchAge-matched control subjectsType 1 diabetes mellitusHealthy age-matched controlsEffects of dysglycemiaEffect of diabetesRisk of hypoglycemiaHealthy control childrenType 1 diabetesAge-matched controlsGreater glycemic variabilityYoung childrenStructural magnetic resonance imaging (MRI) dataGlycemic exposureDiabetes mellitusControl subjectsGlycemic variabilityHippocampal volumeMagnetic resonance imaging dataHippocampus volumeCognitive alterationsHippocampus structureT1DControl childrenLongitudinal assessmentLongitudinal changes
2013
Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
Marzelli MJ, Mazaika PK, Barnea-Goraly N, Hershey T, Tsalikian E, Tamborlane W, Mauras N, White NH, Buckingham B, Beck RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL, Network F. Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes. Diabetes 2013, 63: 343-353. PMID: 24170697, PMCID: PMC3868050, DOI: 10.2337/db13-0179.Peer-Reviewed Original ResearchConceptsGray matter volumeT1D groupControl subjectsWhole brain volumetric analysisAge-matched control subjectsEarly-onset T1DNeuroanatomical correlatesType 1 diabetesRegional brain volumesYoung childrenVoxel-based morphometryMedial prefrontal cortexGlycemic dysregulationGlycemic exposureTemporal-occipital regionsTemporal pole regionsStructural magnetic resonance imagesHyperglycemic exposureMatter volumeBrain volumeType 1Cerebellar regionsPrefrontal cortexBrain structuresMagnetic resonance images