2022
Thermal effects on neurons during stimulation of the brain
Kim T, Kadji H, Whalen A, Ashourvan A, Freeman E, Fried S, Tadigadapa S, Schiff S. Thermal effects on neurons during stimulation of the brain. Journal Of Neural Engineering 2022, 19: 056029. PMID: 36126646, PMCID: PMC9855718, DOI: 10.1088/1741-2552/ac9339.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiophysicsBrainElectric ConductivityElectric StimulationElectrodesMammalsNeuronsConceptsThermal effectsJoule heatingMagnetic coilsRate dependencyElectrical interactionsSmall thermal effectsTemperature changesDissipation of energyNumerical modelingRange of frequenciesThermal energyMagnetic fieldDC drivingMagnetic inductionElectrical currentStatic magnetic fieldSmall temperature increaseTemperature increaseAccurate modulationCoilEnergy depositionHeatingConductorsTransient effectsElectrode
2018
Control of Spreading Depression with Electrical Fields
Whalen A, Xiao Y, Kadji H, Dahlem M, Gluckman B, Schiff S. Control of Spreading Depression with Electrical Fields. Scientific Reports 2018, 8: 8769. PMID: 29884896, PMCID: PMC5993812, DOI: 10.1038/s41598-018-26986-1.Peer-Reviewed Original ResearchConceptsElectric fieldField polarityDC electric fieldElectric field polarityElectrical controlOptical imagingPropagation pathIntrinsic optical imagingOpposite signDepression propagatesElectrical fieldField terminationElectro-chemical gradientPropagation velocityPropagatesFieldTraumatic brain injuryPropagationConfinementMore superficial layersDepression propagationBrain injurySynaptic transmissionBrain slicesWaves
2015
The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization
Ullah G, Wei Y, Dahlem M, Wechselberger M, Schiff S. The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization. PLOS Computational Biology 2015, 11: e1004414. PMID: 26273829, PMCID: PMC4537206, DOI: 10.1371/journal.pcbi.1004414.Peer-Reviewed Original ResearchConceptsAnoxic depolarizationCell swellingDynamics of seizuresGlial KNeuroprotective roleSpreading DepressionEpileptic seizuresSeizuresPhysiological ceilingDepression statePathological activityCell volumeNeuronal dynamicsDepressionPathological statesSeparate seizuresIntervention strategiesNeuron membraneDepolarizationUse of volumeNeuronal behaviorOxygen homeostasisOxygen supplyCells swellSwelling
2014
Unification of Neuronal Spikes, Seizures, and Spreading Depression
Wei Y, Ullah G, Schiff S. Unification of Neuronal Spikes, Seizures, and Spreading Depression. Journal Of Neuroscience 2014, 34: 11733-11743. PMID: 25164668, PMCID: PMC4145176, DOI: 10.1523/jneurosci.0516-14.2014.Peer-Reviewed Original ResearchOxygen and seizure dynamics: II. Computational modeling
Wei Y, Ullah G, Ingram J, Schiff S. Oxygen and seizure dynamics: II. Computational modeling. Journal Of Neurophysiology 2014, 112: 213-223. PMID: 24671540, PMCID: PMC4064403, DOI: 10.1152/jn.00541.2013.Peer-Reviewed Original ResearchConceptsSeizure eventsTissue oxygen pressureIntense neuronal firingSeizure patternsInhibitory neuronsNeuronal firingEpileptic seizuresSeizuresElectrophysiological recordingsOxygen metabolismSeizure dynamicsMetabolic energy consumptionEnergy metabolismExcitatoryMicroenvironment dynamicsRecent studies
2013
Model-based rational feedback controller design for closed-loop deep brain stimulation of Parkinson's disease
Gorzelic P, Schiff S, Sinha A. Model-based rational feedback controller design for closed-loop deep brain stimulation of Parkinson's disease. Journal Of Neural Engineering 2013, 10: 026016. PMID: 23449002, DOI: 10.1088/1741-2560/10/2/026016.Peer-Reviewed Original ResearchConceptsFeedback controller designController designPID controlHigh-level control strategyBetter controller performanceFeedback control methodFeedback control problemController performanceDerivative controlControl methodFeedback controllerControl inputControl lawControl strategyProportional controlOnline estimatesComputational modelControl problemConsiderable further reductionDerivative methodologyOptimal controlAdaptive methodRelay capabilityStimulation algorithmDesignSynchronization and desynchronization in epilepsy: controversies and hypotheses
Jiruska P, de Curtis M, Jefferys J, Schevon C, Schiff S, Schindler K. Synchronization and desynchronization in epilepsy: controversies and hypotheses. The Journal Of Physiology 2013, 591: 787-797. PMID: 23184516, PMCID: PMC3591697, DOI: 10.1113/jphysiol.2012.239590.Peer-Reviewed Original ResearchConceptsNeuronal firingPathophysiology of epilepsyFunctional brain disordersEnd of seizureEpileptiform phenomenaLocal field potentialsLarge neuronal populationsNeuronal populationsNon-firing neuronsBrain disordersSeizuresSpecific inhibitoryEpilepsyExcitatory interactionsNeuronal networksRecent evidenceField potentialsHypersynchronous statesExcessive synchronizationFiring
2012
Modulation of hippocampal rhythms by subthreshold electric fields and network topology
Berzhanskaya J, Chernyy N, Gluckman B, Schiff S, Ascoli G. Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal Of Computational Neuroscience 2012, 34: 369-389. PMID: 23053863, PMCID: PMC3549326, DOI: 10.1007/s10827-012-0426-4.Peer-Reviewed Original ResearchConceptsPyramidal cellsGamma rhythmsHippocampal rhythmsSubthreshold electric fieldsSpecific synaptic connectivityExact cellular mechanismsExcitatory contactsSynaptic circuitryBasket cellsLines of resultsArea CA1Inhibitory connectivityInterneuron typesSynaptic connectivityInterneuron classesHippocampal functionNeuron typesNeuronal morphologyTheta/gamma ratioCognitive functionTheta frequencyCellular mechanismsNeural activityElectrophysiological dataNovel role
2009
Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit
Schachter S, Guttag J, Schiff S, Schomer D, Contributors S. Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit. Epilepsy & Behavior 2009, 16: 3-46. PMID: 19780225, PMCID: PMC8118381, DOI: 10.1016/j.yebeh.2009.06.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsBrain MappingChildDrug ResistanceElectric Stimulation TherapyElectroencephalographyEngineeringEpilepsyHumansMagnetic Resonance ImagingMedical Laboratory ScienceMicroelectrodesNanoparticlesNeuronsNeurosurgeryNeurotoxinsPredictive Value of TestsSeizuresSpectroscopy, Near-InfraredTomography, Emission-Computed, Single-PhotonTomography, OpticalTranscranial Magnetic StimulationConceptsTreatment systemEvaluation of patientsTreatment of patientsGroup of cliniciansEpilepsy surgeryEngineering technologyFurther technological developmentEpilepsySeizure onset detectionPatientsEngineersSeizure predictionTechnologyApplicationsOnset detectionSurgeryCliniciansPhysiciansUnmetDiagnosisTracking and control of neuronal Hodgkin-Huxley dynamics
Ullah G, Schiff S. Tracking and control of neuronal Hodgkin-Huxley dynamics. Physical Review E 2009, 79: 040901. PMID: 19518166, PMCID: PMC2713719, DOI: 10.1103/physreve.79.040901.Peer-Reviewed Original ResearchThe influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics
Cressman J, Ullah G, Ziburkus J, Schiff S, Barreto E. The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics. Journal Of Computational Neuroscience 2009, 26: 159-170. PMID: 19169801, PMCID: PMC2704057, DOI: 10.1007/s10827-008-0132-4.Peer-Reviewed Original ResearchConceptsSingle neuron dynamicsDetailed bifurcation analysisLarge amplitude oscillationsExtracellular ion concentration dynamicsMathematical modelBifurcation analysisDynamical mechanismIon concentration dynamicsNeuron dynamicsReasonable approximationFull modelCompanion paperDynamicsImportant fundamental processesConcentration dynamicsKalman Meets Neuron: The Emerging Intersection of Control Theory with Neuroscience
Schiff S. Kalman Meets Neuron: The Emerging Intersection of Control Theory with Neuroscience. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2009, 2009: 3318-3321. PMID: 19964302, PMCID: PMC3644303, DOI: 10.1109/iembs.2009.5333752.Peer-Reviewed Original ResearchConceptsControl theoryNonlinear control theoryModern control theoryKalman filtering techniqueSingle neuron dynamicsComplex network dataWave dynamicsModel networksControl frameworkComputational neuroscienceNeuron dynamicsFiltering techniqueAccurate reconstructionMature theoryTheoryDynamicsNetwork dataKalmanConsensus setNeuroscience modelsField
2008
The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: II. Network and glial dynamics
Ullah G, Cressman Jr. J, Barreto E, Schiff S. The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: II. Network and glial dynamics. Journal Of Computational Neuroscience 2008, 26: 171-183. PMID: 19083088, PMCID: PMC2951284, DOI: 10.1007/s10827-008-0130-6.Peer-Reviewed Original ResearchMulti-taper transfer function estimation for stimulation artifact removal from neural recordings
Chernyy N, Schiff S, Gluckman B. Multi-taper transfer function estimation for stimulation artifact removal from neural recordings. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2008, 2008: 2772-2776. PMID: 19163280, PMCID: PMC3547985, DOI: 10.1109/iembs.2008.4649777.Peer-Reviewed Original Research
2005
A Model of the Effects of Applied Electric Fields on Neuronal Synchronization
Park E, Barreto E, Gluckman B, Schiff S, So P. A Model of the Effects of Applied Electric Fields on Neuronal Synchronization. Journal Of Computational Neuroscience 2005, 19: 53-70. PMID: 16133825, PMCID: PMC1752229, DOI: 10.1007/s10827-005-0214-5.Peer-Reviewed Original ResearchControl of Traveling Waves in the Mammalian Cortex
Richardson K, Schiff S, Gluckman B. Control of Traveling Waves in the Mammalian Cortex. Physical Review Letters 2005, 94: 028103. PMID: 15698234, PMCID: PMC1513188, DOI: 10.1103/physrevlett.94.028103.Peer-Reviewed Original Research
2004
Spiral Waves in Disinhibited Mammalian Neocortex
Huang X, Troy W, Yang Q, Ma H, Laing C, Schiff S, Wu J. Spiral Waves in Disinhibited Mammalian Neocortex. Journal Of Neuroscience 2004, 24: 9897-9902. PMID: 15525774, PMCID: PMC4413915, DOI: 10.1523/jneurosci.2705-04.2004.Peer-Reviewed Original Research
2003
Interplay of Electroencephalogram Phase and Auditory-Evoked Neural Activity
Kruglikov S, Schiff S. Interplay of Electroencephalogram Phase and Auditory-Evoked Neural Activity. Journal Of Neuroscience 2003, 23: 10122-10127. PMID: 14602828, PMCID: PMC6740863, DOI: 10.1523/jneurosci.23-31-10122.2003.Peer-Reviewed Original ResearchSensitivity of Neurons to Weak Electric Fields
Francis J, Gluckman B, Schiff S. Sensitivity of Neurons to Weak Electric Fields. Journal Of Neuroscience 2003, 23: 7255-7261. PMID: 12917358, PMCID: PMC6740448, DOI: 10.1523/jneurosci.23-19-07255.2003.Peer-Reviewed Original Research
2002
Failure of single-unit neuronal activity to differentiate globus pallidus internus and externus in Parkinson disease.
Schiff S, Dunagan B, Worth R. Failure of single-unit neuronal activity to differentiate globus pallidus internus and externus in Parkinson disease. Journal Of Neurosurgery 2002, 97: 119-28. PMID: 12134901, DOI: 10.3171/jns.2002.97.1.0119.Peer-Reviewed Original ResearchConceptsGlobus pallidus internusSingle-unit activityParkinson's diseaseNeuronal activitySingle-unit neuronal activitySingle unit neuronal recordingsFinal electrode placementElectrode placementMean firing frequencyTotal spectral powerPallidal surgeryMicroelectrode recordingsFiring frequencyOperating roomNeuronal recordingsInternusDiseaseExternusSpectral powerRecordingsPallidotomyPatientsSurgeryLesionsActivity