2015
The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization
Ullah G, Wei Y, Dahlem M, Wechselberger M, Schiff S. The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization. PLOS Computational Biology 2015, 11: e1004414. PMID: 26273829, PMCID: PMC4537206, DOI: 10.1371/journal.pcbi.1004414.Peer-Reviewed Original ResearchConceptsAnoxic depolarizationCell swellingDynamics of seizuresGlial KNeuroprotective roleSpreading DepressionEpileptic seizuresSeizuresPhysiological ceilingDepression statePathological activityCell volumeNeuronal dynamicsDepressionPathological statesSeparate seizuresIntervention strategiesNeuron membraneDepolarizationUse of volumeNeuronal behaviorOxygen homeostasisOxygen supplyCells swellSwelling
1987
The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra.
Schiff S, Somjen G. The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra. Stroke 1987, 18: 30-37. PMID: 3027927, DOI: 10.1161/01.str.18.1.30.Peer-Reviewed Original ResearchConceptsMild hypoxiaSynaptic transmissionModerate hypoxiaHippocampal slicesGrade of hypoxiaHypoxic brain tissueExtracellular DC potentialDegree of hypoxiaPosthypoxic hyperexcitabilityIschemic penumbraExtracellular calciumExtracellular potassiumSynaptic functionBrain tissueHypoxiaHyperexcitabilityExtracellular pHSlicesSevere depolarizationNeuronsDC potentialResponse