2013
Model-based rational feedback controller design for closed-loop deep brain stimulation of Parkinson's disease
Gorzelic P, Schiff S, Sinha A. Model-based rational feedback controller design for closed-loop deep brain stimulation of Parkinson's disease. Journal Of Neural Engineering 2013, 10: 026016. PMID: 23449002, DOI: 10.1088/1741-2560/10/2/026016.Peer-Reviewed Original ResearchConceptsFeedback controller designController designPID controlHigh-level control strategyBetter controller performanceFeedback control methodFeedback control problemController performanceDerivative controlControl methodFeedback controllerControl inputControl lawControl strategyProportional controlOnline estimatesComputational modelControl problemConsiderable further reductionDerivative methodologyOptimal controlAdaptive methodRelay capabilityStimulation algorithmDesign
2010
Towards model-based control of Parkinson's disease
Schiff S. Towards model-based control of Parkinson's disease. Philosophical Transactions Of The Royal Society A Mathematical Physical And Engineering Sciences 2010, 368: 2269-2308. PMID: 20368246, PMCID: PMC2944387, DOI: 10.1098/rsta.2010.0050.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsComputer SimulationGlobus PallidusHumansModels, BiologicalNerve NetNeurosciencesParkinson DiseaseThalamus
2002
Failure of single-unit neuronal activity to differentiate globus pallidus internus and externus in Parkinson disease.
Schiff S, Dunagan B, Worth R. Failure of single-unit neuronal activity to differentiate globus pallidus internus and externus in Parkinson disease. Journal Of Neurosurgery 2002, 97: 119-28. PMID: 12134901, DOI: 10.3171/jns.2002.97.1.0119.Peer-Reviewed Original ResearchConceptsGlobus pallidus internusSingle-unit activityParkinson's diseaseNeuronal activitySingle-unit neuronal activitySingle unit neuronal recordingsFinal electrode placementElectrode placementMean firing frequencyTotal spectral powerPallidal surgeryMicroelectrode recordingsFiring frequencyOperating roomNeuronal recordingsInternusDiseaseExternusSpectral powerRecordingsPallidotomyPatientsSurgeryLesionsActivity