2014
Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy
Sedigh-Sarvestani M, Thuku G, Sunderam S, Parkar A, Weinstein S, Schiff S, Gluckman B. Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy. Journal Of Neuroscience 2014, 34: 1105-1114. PMID: 24453303, PMCID: PMC3898281, DOI: 10.1523/jneurosci.3103-13.2014.Peer-Reviewed Original ResearchConceptsRapid eye movement (REM) sleepNonrapid eye movement sleepEye movement sleepHippocampal theta rhythmState of vigilanceTemporal lobe epilepsyMovement sleepSeizure onsetLobe epilepsySeizure susceptibilityTheta rhythmChronic spontaneous seizuresNatural behavioral statesTetanus toxin modelHalf of baselineSpontaneous seizuresSeizure rateVentral hippocampusToxin modelSeizuresSurvival analysisTetanus toxinTherapeutic potentialREM boutsProminent theta
2012
The role of inhibition in oscillatory wave dynamics in the cortex
Xiao Y, Huang X, Van Wert S, Barreto E, Wu J, Gluckman B, Schiff S. The role of inhibition in oscillatory wave dynamics in the cortex. European Journal Of Neuroscience 2012, 36: 2201-2212. PMID: 22805065, PMCID: PMC4410882, DOI: 10.1111/j.1460-9568.2012.08132.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBicucullineCarbacholEpilepsies, PartialGABA-A Receptor AgonistsGABA-A Receptor AntagonistsGABA-B Receptor AgonistsGABA-B Receptor AntagonistsMaleMembrane PotentialsModels, NeurologicalNeocortexNeural InhibitionPicrotoxinRatsRats, Sprague-DawleyReceptors, AMPAReceptors, GABA-AReceptors, GABA-BReceptors, N-Methyl-D-AspartateTheta RhythmConceptsGABAergic inhibitionNeocortical brain slicesVoltage-sensitive dye imagingSprague-Dawley ratsPresence of carbacholConcentration-dependent mannerGABAB antagonistGABAA receptorsBrain slicesTheta frequency oscillationsPharmacological methodsDye imagingCortical oscillationsRole of inhibitionBicucullineDisinhibitionGABAATheta oscillationsCortexBasic spatiotemporal patternsInhibitionNeural information processingCarbacholMental tasksAntagonist