2018
Control of Spreading Depression with Electrical Fields
Whalen A, Xiao Y, Kadji H, Dahlem M, Gluckman B, Schiff S. Control of Spreading Depression with Electrical Fields. Scientific Reports 2018, 8: 8769. PMID: 29884896, PMCID: PMC5993812, DOI: 10.1038/s41598-018-26986-1.Peer-Reviewed Original ResearchConceptsElectric fieldField polarityDC electric fieldElectric field polarityElectrical controlOptical imagingPropagation pathIntrinsic optical imagingOpposite signDepression propagatesElectrical fieldField terminationElectro-chemical gradientPropagation velocityPropagatesFieldTraumatic brain injuryPropagationConfinementMore superficial layersDepression propagationBrain injurySynaptic transmissionBrain slicesWaves
1988
Reversible Synaptic Blockade Caused by Hypoxia of Moderate Degree in Hippocampal Tissues Slices
Schiff S, Somjen G. Reversible Synaptic Blockade Caused by Hypoxia of Moderate Degree in Hippocampal Tissues Slices. Advances In Behavioral Biology 1988, 35: 175-182. DOI: 10.1007/978-1-4684-5562-5_20.Peer-Reviewed Original ResearchArtificial cerebrospinal fluidHypoxic episodesIschemic brain infarctsModerate hypoxic episodesOrthodromic population spikesReversible synaptic blockadeExcitatory postsynaptic potentialsInterstitial potassium concentrationAfferent fiber volleysHippocampal tissue slicesImpairment of membraneTissue slicesPosthypoxic hyperexcitabilityBrain infarctsSynaptic blockadePopulation spikesReadmission of oxygenFiber volleyPostsynaptic potentialsCA1 regionPyramidal cellsRat hippocampusSynaptic transmissionCerebrospinal fluidCalcium levels
1987
The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra.
Schiff S, Somjen G. The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra. Stroke 1987, 18: 30-37. PMID: 3027927, DOI: 10.1161/01.str.18.1.30.Peer-Reviewed Original ResearchConceptsMild hypoxiaSynaptic transmissionModerate hypoxiaHippocampal slicesGrade of hypoxiaHypoxic brain tissueExtracellular DC potentialDegree of hypoxiaPosthypoxic hyperexcitabilityIschemic penumbraExtracellular calciumExtracellular potassiumSynaptic functionBrain tissueHypoxiaHyperexcitabilityExtracellular pHSlicesSevere depolarizationNeuronsDC potentialResponse
1986
Selective neuronal vulnerability to hypoxia in vitro
Aitken P, Schiff S. Selective neuronal vulnerability to hypoxia in vitro. Neuroscience Letters 1986, 67: 92-96. PMID: 3014393, DOI: 10.1016/0304-3940(86)90215-6.Peer-Reviewed Original Research
1985
The effects of temperature on synaptic transmission in hippocampal tissue slices
Schiff S, Somjen G. The effects of temperature on synaptic transmission in hippocampal tissue slices. Brain Research 1985, 345: 279-284. PMID: 2994845, DOI: 10.1016/0006-8993(85)91004-2.Peer-Reviewed Original ResearchGlutamine can enhance synaptic transmission in hippocampal slices
Schiff S, Szerb J, Somjen G. Glutamine can enhance synaptic transmission in hippocampal slices. Brain Research 1985, 343: 366-369. PMID: 2996699, DOI: 10.1016/0006-8993(85)90758-9.Peer-Reviewed Original Research