2021
Spreading depression as an innate antiseizure mechanism
Tamim I, Chung D, de Morais A, Loonen I, Qin T, Misra A, Schlunk F, Endres M, Schiff S, Ayata C. Spreading depression as an innate antiseizure mechanism. Nature Communications 2021, 12: 2206. PMID: 33850125, PMCID: PMC8044138, DOI: 10.1038/s41467-021-22464-x.Peer-Reviewed Original ResearchConceptsFocal neocortical seizuresSystemic kainic acidCentral nervous systemVivo mouse modelAntiseizure mechanismsAntiseizure effectsSeizure generalizationFocal seizuresSD occurrenceNeocortical seizuresKainic acidBrain injuryMouse modelNervous systemSeizuresNeurological disordersProlonged depolarizationSDDepressionBicucullineMigraineInjury
2016
A Unified Framework for Neuronal Spikes, Seizures, Spreading Depression, and Ischemia-Induced Anoxic Depolarization
Ullah G, Wei Y, Schiff S. A Unified Framework for Neuronal Spikes, Seizures, Spreading Depression, and Ischemia-Induced Anoxic Depolarization. Biophysical Journal 2016, 110: 632a. DOI: 10.1016/j.bpj.2015.11.3383.Peer-Reviewed Original Research
2015
The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization
Ullah G, Wei Y, Dahlem M, Wechselberger M, Schiff S. The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization. PLOS Computational Biology 2015, 11: e1004414. PMID: 26273829, PMCID: PMC4537206, DOI: 10.1371/journal.pcbi.1004414.Peer-Reviewed Original ResearchConceptsAnoxic depolarizationCell swellingDynamics of seizuresGlial KNeuroprotective roleSpreading DepressionEpileptic seizuresSeizuresPhysiological ceilingDepression statePathological activityCell volumeNeuronal dynamicsDepressionPathological statesSeparate seizuresIntervention strategiesNeuron membraneDepolarizationUse of volumeNeuronal behaviorOxygen homeostasisOxygen supplyCells swellSwelling
2014
Oxygen and seizure dynamics: II. Computational modeling
Wei Y, Ullah G, Ingram J, Schiff S. Oxygen and seizure dynamics: II. Computational modeling. Journal Of Neurophysiology 2014, 112: 213-223. PMID: 24671540, PMCID: PMC4064403, DOI: 10.1152/jn.00541.2013.Peer-Reviewed Original ResearchConceptsSeizure eventsTissue oxygen pressureIntense neuronal firingSeizure patternsInhibitory neuronsNeuronal firingEpileptic seizuresSeizuresElectrophysiological recordingsOxygen metabolismSeizure dynamicsMetabolic energy consumptionEnergy metabolismExcitatoryMicroenvironment dynamicsRecent studiesOxygen and seizure dynamics: I. Experiments
Ingram J, Zhang C, Cressman J, Hazra A, Wei Y, Koo Y, Žiburkus J, Kopelman R, Xu J, Schiff S. Oxygen and seizure dynamics: I. Experiments. Journal Of Neurophysiology 2014, 112: 205-212. PMID: 24598521, PMCID: PMC4064411, DOI: 10.1152/jn.00540.2013.Peer-Reviewed Original ResearchConceptsEpileptiform activityRat hippocampal slicesLayer-specific patternsSeizure-like eventsSeizure-like stateSpontaneous seizure-like eventsHippocampal slicesSeizure onsetNeuronal interplayCellular excitabilitySeizure dynamicsEndogenous hypoxiaGreater reductionO2 utilizationHypoxiaElectrical recordingsSeizuresCA1ExcitabilityPyramidaleRapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy
Sedigh-Sarvestani M, Thuku G, Sunderam S, Parkar A, Weinstein S, Schiff S, Gluckman B. Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy. Journal Of Neuroscience 2014, 34: 1105-1114. PMID: 24453303, PMCID: PMC3898281, DOI: 10.1523/jneurosci.3103-13.2014.Peer-Reviewed Original ResearchConceptsRapid eye movement (REM) sleepNonrapid eye movement sleepEye movement sleepHippocampal theta rhythmState of vigilanceTemporal lobe epilepsyMovement sleepSeizure onsetLobe epilepsySeizure susceptibilityTheta rhythmChronic spontaneous seizuresNatural behavioral statesTetanus toxin modelHalf of baselineSpontaneous seizuresSeizure rateVentral hippocampusToxin modelSeizuresSurvival analysisTetanus toxinTherapeutic potentialREM boutsProminent theta
2013
Synchronization and desynchronization in epilepsy: controversies and hypotheses
Jiruska P, de Curtis M, Jefferys J, Schevon C, Schiff S, Schindler K. Synchronization and desynchronization in epilepsy: controversies and hypotheses. The Journal Of Physiology 2013, 591: 787-797. PMID: 23184516, PMCID: PMC3591697, DOI: 10.1113/jphysiol.2012.239590.Peer-Reviewed Original ResearchConceptsNeuronal firingPathophysiology of epilepsyFunctional brain disordersEnd of seizureEpileptiform phenomenaLocal field potentialsLarge neuronal populationsNeuronal populationsNon-firing neuronsBrain disordersSeizuresSpecific inhibitoryEpilepsyExcitatory interactionsNeuronal networksRecent evidenceField potentialsHypersynchronous statesExcessive synchronizationFiring
2012
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events
Žiburkus J, Cressman J, Schiff S. Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. Journal Of Neurophysiology 2012, 109: 1296-1306. PMID: 23221405, PMCID: PMC3602838, DOI: 10.1152/jn.00232.2012.Peer-Reviewed Original ResearchConceptsSeizure-like eventsO-LM cellsPyramidal cellsInhibitory conductanceOriens-lacunosum moleculare (O-LM) interneuronsNeuronal network hyperexcitabilityExcitability of interneuronsCA1 pyramidal cellsInhibitory synaptic conductancesNetwork hyperexcitabilityRecurrent seizuresMoleculare interneuronsSeizure initiationNeural network activityRat hippocampusExtracellular magnesiumSynaptic barragesFiring patternsSeizuresExcitatoryCellular subtypesSynaptic conductancesInterneuronsNetwork activityCell types
2009
Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model. Journal Of Neural Engineering 2009, 6: 046009. PMID: 19602730, PMCID: PMC3057918, DOI: 10.1088/1741-2560/6/4/046009.Peer-Reviewed Original ResearchConceptsField postsynaptic potentialsAnimal epilepsy modelsNeural activitySimultaneous recordingSpontaneous seizuresHippocampal epilepsyVentral hippocampusEpilepsy modelLocal field potentialsPostsynaptic potentialsNeuronal excitabilityNeuronal activityModulatory effectsAnimal modelsSeizuresStatistical significanceStimulationField potentialsMultiple presentationsAnimalsCharacteristic patternEpilepsyHippocampusRecordingsExcitability
2008
30 Towards a Dynamics of Seizure Mechanics
Schiff S, Cressman J, Barreto E, Žiburkus J. 30 Towards a Dynamics of Seizure Mechanics. 2008, 496-xviii. DOI: 10.1016/b978-012373649-9.50033-8.Peer-Reviewed Original ResearchDepolarization blockRelevant neuronal subtypesExcitatory principal cellsHippocampal seizuresGap junction connectivityPyramidal cellsHuman epilepsyInhibitory interneuronsIntracellular recordingsSynaptic currentsNeuronal subtypesHuman seizuresSeizuresInterneuronsPrincipal cellsSeizure dynamicsTime courseSynchrony featuresNeuronal dynamicsCellsEpilepsy
2006
Seizure Modulation with Applied Electric Fields in Chronically Implanted Animals
Sunderam S, Chernyy N, Mason J, Peixoto N, Weinstein S, Schiff S, Gluckman B. Seizure Modulation with Applied Electric Fields in Chronically Implanted Animals. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2006, 2006: 1612-1615. PMID: 17946910, PMCID: PMC3547984, DOI: 10.1109/iembs.2006.259454.Peer-Reviewed Original Research
2003
Electric field modulation of synchronization in neuronal networks
Park E, So P, Barreto E, Gluckman B, Schiff S. Electric field modulation of synchronization in neuronal networks. Neurocomputing 2003, 52: 169-175. DOI: 10.1016/s0925-2312(02)00820-2.Peer-Reviewed Original Research
1998
Forecasting brain storms
Schiff S. Forecasting brain storms. Nature Medicine 1998, 4: 1117-1118. PMID: 9771736, DOI: 10.1038/2610.Peer-Reviewed Original Research
1995
Matched-filter based detection and localization of epileptic seizures from spectrographic chirps in ECoG recordings
Creekmore J, Conry J, Colella D, Schiff S. Matched-filter based detection and localization of epileptic seizures from spectrographic chirps in ECoG recordings. 1995, 2: 891-892 vol.2. DOI: 10.1109/iembs.1995.579256.Peer-Reviewed Original ResearchFeature-based detection of epileptic seizures using ECoG recordings and a PAM model
Hughes E, Gaillard W, Jacyna G, Schiff S. Feature-based detection of epileptic seizures using ECoG recordings and a PAM model. 1995, 2: 933-934 vol.2. DOI: 10.1109/iembs.1995.579355.Peer-Reviewed Original Research