2012
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events
Žiburkus J, Cressman J, Schiff S. Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. Journal Of Neurophysiology 2012, 109: 1296-1306. PMID: 23221405, PMCID: PMC3602838, DOI: 10.1152/jn.00232.2012.Peer-Reviewed Original ResearchConceptsSeizure-like eventsO-LM cellsPyramidal cellsInhibitory conductanceOriens-lacunosum moleculare (O-LM) interneuronsNeuronal network hyperexcitabilityExcitability of interneuronsCA1 pyramidal cellsInhibitory synaptic conductancesNetwork hyperexcitabilityRecurrent seizuresMoleculare interneuronsSeizure initiationNeural network activityRat hippocampusExtracellular magnesiumSynaptic barragesFiring patternsSeizuresExcitatoryCellular subtypesSynaptic conductancesInterneuronsNetwork activityCell types
1988
Reversible Synaptic Blockade Caused by Hypoxia of Moderate Degree in Hippocampal Tissues Slices
Schiff S, Somjen G. Reversible Synaptic Blockade Caused by Hypoxia of Moderate Degree in Hippocampal Tissues Slices. Advances In Behavioral Biology 1988, 35: 175-182. DOI: 10.1007/978-1-4684-5562-5_20.Peer-Reviewed Original ResearchArtificial cerebrospinal fluidHypoxic episodesIschemic brain infarctsModerate hypoxic episodesOrthodromic population spikesReversible synaptic blockadeExcitatory postsynaptic potentialsInterstitial potassium concentrationAfferent fiber volleysHippocampal tissue slicesImpairment of membraneTissue slicesPosthypoxic hyperexcitabilityBrain infarctsSynaptic blockadePopulation spikesReadmission of oxygenFiber volleyPostsynaptic potentialsCA1 regionPyramidal cellsRat hippocampusSynaptic transmissionCerebrospinal fluidCalcium levels