2021
Spreading depression as an innate antiseizure mechanism
Tamim I, Chung D, de Morais A, Loonen I, Qin T, Misra A, Schlunk F, Endres M, Schiff S, Ayata C. Spreading depression as an innate antiseizure mechanism. Nature Communications 2021, 12: 2206. PMID: 33850125, PMCID: PMC8044138, DOI: 10.1038/s41467-021-22464-x.Peer-Reviewed Original ResearchConceptsFocal neocortical seizuresSystemic kainic acidCentral nervous systemVivo mouse modelAntiseizure mechanismsAntiseizure effectsSeizure generalizationFocal seizuresSD occurrenceNeocortical seizuresKainic acidBrain injuryMouse modelNervous systemSeizuresNeurological disordersProlonged depolarizationSDDepressionBicucullineMigraineInjury
1995
Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children
Heyes M, Saito K, Milstien S, Schiff S. Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. Journal Of The Neurological Sciences 1995, 133: 112-118. PMID: 8583213, DOI: 10.1016/0022-510x(95)00164-w.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBacterial InfectionsBiomarkersBiopterinCentral Nervous System DiseasesCentral Nervous System NeoplasmsCerebral HemorrhageChildChild, PreschoolFemaleGuanosine TriphosphateHumansHydrocephalusInfantInfant, NewbornInterleukin-6KynurenineMaleNeopterinQuinolinic AcidTryptophan OxygenaseTumor Necrosis Factor-alphaConceptsCentral nervous systemQuinolinic acidImmune activationKynurenine pathwayNervous systemBacterial infectionsLevels of QUINCentral nervous system infectionCSF QUIN levelsNervous system infectionCytokine tumor necrosisCNS inflammationNeurological deficitsSystem infectionNeurologic dysfunctionCSF levelsQUIN levelsQUIN concentrationsInterleukin-6Tumor necrosisCerebrospinal fluidNeurotoxic metabolitesSensitive markerMacrophage activationPatients