2020
A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection
Alsoussi WB, Turner JS, Case JB, Zhao H, Schmitz AJ, Zhou JQ, Chen RE, Lei T, Rizk AA, McIntire KM, Winkler ES, Fox JM, Kafai NM, Thackray LB, Hassan AO, Amanat F, Krammer F, Watson CT, Kleinstein SH, Fremont DH, Diamond MS, Ellebedy AH. A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. The Journal Of Immunology 2020, 205: ji2000583. PMID: 32591393, PMCID: PMC7566074, DOI: 10.4049/jimmunol.2000583.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2AnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralBetacoronavirusChlorocebus aethiopsCoronavirus InfectionsCOVID-19Disease Models, AnimalEpitope MappingFemaleHEK293 CellsHumansImmunodominant EpitopesMiceMice, Inbred C57BLPandemicsPeptidyl-Dipeptidase APneumonia, ViralProtein Interaction Domains and MotifsSARS-CoV-2Spike Glycoprotein, CoronavirusTransfectionVero CellsConceptsSARS-CoV-2 infectionSARS-CoV-2Receptor-binding domainSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Angiotensin-converting enzyme 2Human angiotensin-converting enzyme 2Wild-type SARS-CoV-2Lung viral loadsSyndrome coronavirus 2Millions of infectionsTrimeric spike glycoproteinLicensed therapeuticsViral loadCoronavirus 2Systemic disseminationEffective antiviralsEnzyme 2Murine modelMurine mAbsEffective interventionsInfectionWeight lossSpike glycoprotein
2016
RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2
Maman Y, Teng G, Seth R, Kleinstein SH, Schatz DG. RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2. Nucleic Acids Research 2016, 44: 9624-9637. PMID: 27436288, PMCID: PMC5175335, DOI: 10.1093/nar/gkw633.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesChromatinChromatin ImmunoprecipitationGenomeGenomic InstabilityHigh-Throughput Nucleotide SequencingHistonesHomeodomain ProteinsHumansMiceNucleotide MotifsPromoter Regions, GeneticProtein BindingProtein Interaction Domains and MotifsRecombination, GeneticV(D)J RecombinationConceptsAntigen receptor lociNon-core regionsReceptor locusPlant homeodomain (PHD) fingerChIP-seq dataWide bindingChromatin interactionsAdditional chromatinLysine 4Off-target activityGenomic featuresHistone 3Novel roleRAG1LociChromatinGenomeRAG2Observed patternsDistinct modesBindingH3K4me3H3K27acEndonucleaseRelative contribution