Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles
Han L, Cai Q, Tian D, Kong DK, Gou X, Chen Z, Strittmatter SM, Wang Z, Sheth KN, Zhou J. Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles. Nanomedicine Nanotechnology Biology And Medicine 2016, 12: 1833-1842. PMID: 27039220, PMCID: PMC5045320, DOI: 10.1016/j.nano.2016.03.005.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine A2 Receptor AgonistsAnimalsBlood-Brain BarrierBrain IschemiaDrug Delivery SystemsHumansMaleMice, Inbred C57BLNanoparticlesPurinesPyrazolesStrokeConceptsDrug deliveryTargeted Drug DeliveryIschemic strokeNanoparticlesDelivery efficiencyTargeting approachesIschemic microenvironmentBlood-brain barrier permeabilityBlood-brain barrierCurrent drug treatmentPotential therapeutic agentPromising strategyInfarct volumeNEP1-40Clinical managementLeading causeBarrier permeabilitySubsequent administrationDrug treatmentStrokeTherapeutic agentsEnhanced survivalDeliveryEfficiencyMicroenvironment