2022
Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats
Asch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats. Neuropsychopharmacology 2022, 48: 489-497. PMID: 36100654, PMCID: PMC9852230, DOI: 10.1038/s41386-022-01441-y.Peer-Reviewed Original ResearchAdolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats
Villiamma P, Casby J, Groman SM. Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology 2022, 239: 2885-2901. PMID: 35705734, PMCID: PMC10332493, DOI: 10.1007/s00213-022-06174-w.Peer-Reviewed Original ResearchConceptsCocaine-taking behaviorReversal-learning performanceDecision-making functionsReversal-learning taskReinforcement learning modelIndividual differencesAdolescent developmentFemale Long-Evans ratsRewarded outcomesDevelopmental trajectoriesNeurobiological mechanismsAdolescent trajectoriesAge-related changesGreater cocaineBiobehavioral mechanismsNeural adaptationLong-Evans ratsPredictive relationshipAddiction susceptibilityAdolescenceChoice behaviorAdulthoodDecision-making trajectoriesMental illnessChoice dataImaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET)
Rossano S, Toyonaga T, Berg E, Lorence I, Fowles K, Nabulsi N, Ropchan J, Li S, Ye Y, Felchner Z, Kukis D, Huang Y, Benveniste H, Tarantal AF, Groman S, Carson RE. Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET). European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3679-3691. PMID: 35633376, PMCID: PMC9826644, DOI: 10.1007/s00259-022-05825-6.Peer-Reviewed Original ResearchConceptsPositron emission tomographySynaptic densityFetal brainThird trimesterEmission tomographyBrain developmentGravid rhesus monkeysPost-mortem brain tissueEarly neonatal periodNonhuman primate brainLate gestational periodSubset of subjectsPostnatal brain developmentPost-mortem samplesGestational ageNeonatal periodPregnant monkeysSynapse numberGestational periodPrimary motorPrimate brainBrain growthSubcortical regionsBrain tissueCortical regionsMicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV
Young JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Research Neuroimaging 2022, 321: 111445. PMID: 35101828, DOI: 10.1016/j.pscychresns.2022.111445.Peer-Reviewed Original ResearchConceptsGp120 transgenic miceWildtype miceTransgenic miceCognitive deficits persistElevated inflammatory profilesPositron emission tomography studyEmission tomography studiesElevated neuroinflammationNeuroinflammatory profileInflammatory profileInflammatory insultVentral striataHIV envelopeLipopolysaccharide treatmentHIV entryMouse modelHIVBehavioral abnormalitiesDeficits persistMiceTomography studyVivo evidenceEnvelope glycoproteinPLWHNeuroinflammation
2021
Reinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDecision-making deficitsPathophysiology of addictionDecision-making strategiesBiobehavioral mechanismsAddictionReinforcement learningDecision-making processDrug useTranslational approachComputational componentsDeficitsLearningDifferent componentsBiological mechanismsOutcomesFindingsRecent studiesBehaviorStudyUnlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex
Groman SM, Lee D, Taylor JR. Unlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex. Behavioral Neuroscience 2021, 135: 120-128. PMID: 34060870, PMCID: PMC8201418, DOI: 10.1037/bne0000414.Peer-Reviewed Original ResearchConceptsOrbitofrontal cortexReinforcement-learning mechanismsDecision-making impairmentsDiverse clinical populationsDecision-making differsNeurocomputational approachOFC dysfunctionNeuroscience techniquesBiobehavioral disordersBehavioral paradigmsClinical populationsBiobehavioral mechanismsAddiction pathologyComputational differencesReinforcement-learning algorithmsThe effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice
Gianessi CA, Groman SM, Taylor JR. The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice. European Journal Of Neuroscience 2021, 55: 922-938. PMID: 33506530, PMCID: PMC10370500, DOI: 10.1111/ejn.15129.Peer-Reviewed Original ResearchConceptsFatty acid amide hydrolase inhibitionResponse rateHydrolase inhibitionCannabinoid receptor type 1Aberrant habit formationInhibition of FAAHMonoacylglycerol lipase inhibitionInconsistent dose-response relationshipRole of CB1RSubstance use disordersEndocannabinoid ligand anandamideReceptor type 1Dose-response relationshipContingency degradation procedureEndocannabinoid signalingClinical utilityAM251Use disordersType 1Behavioral effectsPharmacological compoundsDose-response experimentsMiceLipase inhibitionAnandamide
2020
Reinforcement Learning during Adolescence in Rats
Afshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. Journal Of Neuroscience 2020, 40: 5857-5870. PMID: 32601244, PMCID: PMC7380962, DOI: 10.1523/jneurosci.0910-20.2020.Peer-Reviewed Original ResearchConceptsNovel behavioral protocolReversal-learning performanceAdaptive choice behaviorBehavioral protocolFemale Long-Evans ratsReversal performanceChoice behaviorLong-Evans ratsAdolescent brain functionAge-related improvementsReinforcement-learning mechanismsReversal-learning taskReversal-learning paradigmDecision-making paradigmReinforcement learning mechanismAdolescent ratsLongitudinal designAge-related changesNeurodevelopmental mechanismsAdolescencePositive outcomesBrain functionFunction of circuitsPostnatal day 30AdulthoodDysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats
Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats. Biological Psychiatry 2020, 88: 777-787. PMID: 32826065, PMCID: PMC8935943, DOI: 10.1016/j.biopsych.2020.06.020.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsProbabilistic reversalRelapse-like behaviorTest of motivationReceptor availabilityPersistent drug useMetabotropic glutamate 5Neural mechanismsCompulsive patternsDecision-making processDrug-induced adaptationsSelective impairmentDrug useWeeks of abstinenceCocaine takingCocaine Self-AdministrationBrain regionsDegree of disruptionDays of cocaineAdult male ratsCocaine-induced increasesCocaine-induced changesDrug-induced alterationsRobust alterationsPositron emission tomographyParanoia as a deficit in non-social belief updating
Reed EJ, Uddenberg S, Suthaharan P, Mathys C, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. ELife 2020, 9: e56345. PMID: 32452769, PMCID: PMC7326495, DOI: 10.7554/elife.56345.Peer-Reviewed Original ResearchConceptsParanoid individualsSocial threatLearning differencesTask environmentLearning behaviorOnline participantsMethamphetamine exposureParanoiaBeliefsVolatile environmentMental illnessComputational modelingIndividualsElevated sensitivityDeficitsAnticipationParticipantsParadigmThreatMethamphetamineDifferencesFurther assessmentBehaviorHarmMedial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption
Bond CW, Trinko R, Foscue E, Furman K, Groman SM, Taylor JR, DiLeone RJ. Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption. Journal Of Neuroscience 2020, 40: 4727-4738. PMID: 32354856, PMCID: PMC7294796, DOI: 10.1523/jneurosci.3054-18.2020.Peer-Reviewed Original ResearchConceptsControl food intakeNAc projectionsFood intakeAccumbens projectionsLateral hypothalamusMesolimbic circuitsFood consumptionNucleus accumbens projectionsFood-seeking behaviorNAC controlVTA pathwayInhibitory projectionsMale miceNAc shellOptogenetic activationFiber photometryOptogenetic inhibitionPermissive rolePharmacological studiesDrug rewardVTAConsummatory behaviorIntakeAdaptive inhibitionNeural activityThe Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals
Groman SM. The Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals. Current Topics In Behavioral Neurosciences 2020, 47: 23-52. PMID: 32157666, DOI: 10.1007/7854_2020_127.Peer-Reviewed Original ResearchConceptsImpulsive choiceNonhuman animalsReinforcement learning processSophisticated behavioralImpulsive decisionNeural mechanismsNeuroscience techniquesNeurobiological mechanismsNeuromodulatory systemsBehavioral heterogeneityApplication of reinforcementLearning processNeurochemical basisMental illnessIntegration of reinforcementImpulsivityPathological levelsMidbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration
Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Midbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration. Biological Psychiatry 2020, 88: 767-776. PMID: 32312578, PMCID: PMC8954711, DOI: 10.1016/j.biopsych.2020.02.017.Peer-Reviewed Original ResearchConceptsProbabilistic reversalTests of extinctionSubstance-dependent individualsCue-induced reinstatementRelapse-like behaviorTest of motivationAddiction-like behaviorCocaine self-administration behaviorCocaine-taking behaviorReceptor availabilitySelf-administer cocaineIndividual differencesAddicted populationNeurobiological mechanismsSelf-administration behaviorGreater escalationGreater motivationPoor decisionsNeural adaptationD3 receptor availabilityCocaine Self-AdministrationBehavioral biomarkersDecision-making functionsChoice behaviorRate of escalation
2019
Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes
Groman SM, Keistler C, Keip AJ, Hammarlund E, DiLeone RJ, Pittenger C, Lee D, Taylor JR. Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes. Neuron 2019, 103: 734-746.e3. PMID: 31253468, PMCID: PMC6893860, DOI: 10.1016/j.neuron.2019.05.042.Peer-Reviewed Original ResearchEndocannabinoid contributions to alcohol habits and motivation: Relevance to treatment
Gianessi CA, Groman SM, Thompson SL, Jiang M, van der Stelt M, Taylor JR. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addiction Biology 2019, 25: e12768. PMID: 31056846, PMCID: PMC7790504, DOI: 10.1111/adb.12768.Peer-Reviewed Original ResearchBi‐directional modulation of food habit expression by the endocannabinoid system
Gianessi CA, Groman SM, Taylor JR. Bi‐directional modulation of food habit expression by the endocannabinoid system. European Journal Of Neuroscience 2019, 49: 1610-1622. PMID: 30589475, PMCID: PMC7790508, DOI: 10.1111/ejn.14330.Peer-Reviewed Original ResearchConceptsCannabinoid receptor type 1Endocannabinoid systemTransient receptor potential cationHabitual respondingExpression of habitsMale C57BL/6 miceEndocannabinoid transport inhibitor AM404Potential pharmacological strategiesSubstance use disordersReceptor type 1Bi-directional modulationC57BL/6 micePharmacological strategiesCB1 receptorsPharmacological stimulationUse disordersEnzyme inhibitorsMental disordersType 1Neural circuitsNeuromodulatory systemsGoal-directed actionsSimilar reductionAM404Habit learningModel-Free and Model-Based Influences in Addiction-Related Behaviors
Groman SM, Massi B, Mathias SR, Lee D, Taylor JR. Model-Free and Model-Based Influences in Addiction-Related Behaviors. Biological Psychiatry 2019, 85: 936-945. PMID: 30737015, PMCID: PMC6534429, DOI: 10.1016/j.biopsych.2018.12.017.Peer-Reviewed Original ResearchConceptsDecision-making taskModel-based behaviorModel-free learningModel-based learningAbility of ratsChronic drug useUnrewarded outcomesIndividual differencesDrug-induced disruptionHabitual systemAddiction vulnerabilityModel-free reinforcementBehavioral platformAction selectionDrug useSubsequent methamphetamineCore featuresLearning mechanism
2018
Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task
Groman SM, Massi B, Mathias SR, Curry DW, Lee D, Taylor JR. Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task. Journal Of Neuroscience 2018, 39: 295-306. PMID: 30413646, PMCID: PMC6325257, DOI: 10.1523/jneurosci.2219-18.2018.Peer-Reviewed Original ResearchConceptsMultistage taskBehavioral platformDopamine toneDecision Making TaskValue-based choiceDecision-making taskNovel behavioral paradigmModel-based learningConsequences of actionsReinforcement learning systemNeuroscience studiesBehavioral paradigmsBiobehavioral mechanismsVentral striatumNeurobehavioral levelBehavioral dissectionNovel analytic approachCortex correlatesRetrospective appraisalChoice behaviorTaskBehavioral mechanismsMental disordersModel-based systemLearning
2017
Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats
Groman SM, Rich KM, Smith NJ, Lee D, Taylor JR. Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats. Neuropsychopharmacology 2017, 43: 770-780. PMID: 28741627, PMCID: PMC5809784, DOI: 10.1038/npp.2017.159.Peer-Reviewed Original ResearchConceptsReinforcement learning processAbility of ratsNegative outcomesAdaptive decision-making strategiesProbabilistic reversal learningStimulus-reward contingenciesDopamine D2/3 receptor antagonistDynamic decision makingMaladaptive decisionReversal learningDecision-making strategiesD2/3 receptor antagonistOutcome behaviorsPsychostimulant methamphetamineChronic exposurePsychostimulant addictionChoice behaviorBehavioral mechanismsComputational modelDetrimental outcomesPsychostimulant drugsCurrent studyDecision makingDecision-making processDrug useModel-Based Control in Dimensional Psychiatry
Voon V, Reiter A, Sebold M, Groman S. Model-Based Control in Dimensional Psychiatry. Biological Psychiatry 2017, 82: 391-400. PMID: 28599832, DOI: 10.1016/j.biopsych.2017.04.006.Peer-Reviewed Original Research