2022
Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats
Asch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats. Neuropsychopharmacology 2022, 48: 489-497. PMID: 36100654, PMCID: PMC9852230, DOI: 10.1038/s41386-022-01441-y.Peer-Reviewed Original ResearchAdolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats
Villiamma P, Casby J, Groman SM. Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology 2022, 239: 2885-2901. PMID: 35705734, PMCID: PMC10332493, DOI: 10.1007/s00213-022-06174-w.Peer-Reviewed Original ResearchConceptsCocaine-taking behaviorReversal-learning performanceDecision-making functionsReversal-learning taskReinforcement learning modelIndividual differencesAdolescent developmentFemale Long-Evans ratsRewarded outcomesDevelopmental trajectoriesNeurobiological mechanismsAdolescent trajectoriesAge-related changesGreater cocaineBiobehavioral mechanismsNeural adaptationLong-Evans ratsPredictive relationshipAddiction susceptibilityAdolescenceChoice behaviorAdulthoodDecision-making trajectoriesMental illnessChoice data
2020
Reinforcement Learning during Adolescence in Rats
Afshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. Journal Of Neuroscience 2020, 40: 5857-5870. PMID: 32601244, PMCID: PMC7380962, DOI: 10.1523/jneurosci.0910-20.2020.Peer-Reviewed Original ResearchConceptsNovel behavioral protocolReversal-learning performanceAdaptive choice behaviorBehavioral protocolFemale Long-Evans ratsReversal performanceChoice behaviorLong-Evans ratsAdolescent brain functionAge-related improvementsReinforcement-learning mechanismsReversal-learning taskReversal-learning paradigmDecision-making paradigmReinforcement learning mechanismAdolescent ratsLongitudinal designAge-related changesNeurodevelopmental mechanismsAdolescencePositive outcomesBrain functionFunction of circuitsPostnatal day 30AdulthoodParanoia as a deficit in non-social belief updating
Reed EJ, Uddenberg S, Suthaharan P, Mathys C, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. ELife 2020, 9: e56345. PMID: 32452769, PMCID: PMC7326495, DOI: 10.7554/elife.56345.Peer-Reviewed Original ResearchConceptsParanoid individualsSocial threatLearning differencesTask environmentLearning behaviorOnline participantsMethamphetamine exposureParanoiaBeliefsVolatile environmentMental illnessComputational modelingIndividualsElevated sensitivityDeficitsAnticipationParticipantsParadigmThreatMethamphetamineDifferencesFurther assessmentBehaviorHarm
2017
Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice
Rapanelli M, Frick LR, Xu M, Groman SM, Jindachomthong K, Tamamaki N, Tanahira C, Taylor JR, Pittenger C. Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biological Psychiatry 2017, 82: 194-203. PMID: 28347488, PMCID: PMC5374721, DOI: 10.1016/j.biopsych.2017.01.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxietyAutistic DisorderConditioning, OperantCorpus StriatumDisease Models, AnimalExploratory BehaviorFemaleImmunohistochemistryInterneuronsMaleMice, TransgenicMotor ActivityPrepulse InhibitionRibosomal Protein S6 Kinases, 90-kDaSex CharacteristicsSocial BehaviorStereotyped BehaviorSynaptic TransmissionConceptsCholinergic interneuronsTourette syndromeDorsal striatumFemale miceMale miceLarge cholinergic interneuronsAutism spectrum disorderToxin-mediated ablationAutism-like behavioral abnormalitiesAnxiety-like behaviorActivity-dependent signalingMale predominanceNeuronal abnormalitiesPotential relevancePreclinical modelsNormal miceInterneuron typesInterneuronal populationsBehavioral abnormalitiesBehavioral pathologyStriatumDimorphic mannerNeuropsychiatric disordersInterneuronsBehavioral effects
2016
Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model
Kaneko G, Sanganahalli BG, Groman SM, Wang H, Coman D, Rao J, Herman P, Jiang L, Rich K, de Graaf RA, Taylor JR, Hyder F. Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biological Psychiatry 2016, 81: 503-513. PMID: 27450031, PMCID: PMC5130616, DOI: 10.1016/j.biopsych.2016.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBiomarkersBrainDecision MakingDiffusion Tensor ImagingDisease Models, AnimalFemaleMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMethylazoxymethanol AcetateMultimodal ImagingPrefrontal CortexRatsRats, Sprague-DawleyReversal LearningRewardSchizophreniaSchizophrenic PsychologyConceptsMAM ratsEarly schizophreniaReversal-learning taskEarly behavioral markersResting-state functional magnetic resonanceFunctional magnetic resonanceMethylazoxymethanol acetate (MAM) rat modelFunctional brain biomarkersPerceptual problemsBehavioral markersOrbitofrontal cortexLate adolescenceFunctional connectivityRat modelEarly diagnosisThree-choiceBehavioral studiesBehavioral symptomsPosterior corpus callosumSubstance abuseProdromal patientsSubthreshold symptomsVisual cortexBrain biomarkersSaline-treated controls
2014
Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex
Elsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE, Kim JD, Diano S, Roth RH. Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex. The International Journal Of Neuropsychopharmacology 2014, 18: pyu048. PMID: 25522392, PMCID: PMC4438537, DOI: 10.1093/ijnp/pyu048.Peer-Reviewed Original ResearchConceptsSpine synapse numberDorsolateral prefrontal cortexDopamine turnoverPhencyclidine treatmentSpine synapsesSynapse numberCognitive deficitsPrefrontal cortexPhencyclidine modelMale monkeysJuvenile monkeysSchizophrenia-related cognitive deficitsDendritic spine synapsesIncidence of schizophreniaAdult male monkeysSex-specific effectsMessenger RNABDNF expressionNeurotrophic factorNovel treatmentsCombined groupAdult nonhumanCore symptomsCortexNonhuman primatesSex chromosome complement influences operant responding for a palatable food in mice
Seu E, Groman SM, Arnold AP, Jentsch JD. Sex chromosome complement influences operant responding for a palatable food in mice. Genes Brain & Behavior 2014, 13: 527-534. PMID: 24861924, PMCID: PMC4079740, DOI: 10.1111/gbb.12143.Peer-Reviewed Original Research
2013
Diminished neurokinin‐1 receptor availability in patients with two forms of chronic visceral pain
Jarcho JM, Feier NA, Bert A, Labus JA, Lee M, Stains J, Ebrat B, Groman SM, Tillisch K, Brody AL, London ED, Mandelkern MA, Mayer EA. Diminished neurokinin‐1 receptor availability in patients with two forms of chronic visceral pain. Pain 2013, 154: 987-996. PMID: 23582152, PMCID: PMC4294187, DOI: 10.1016/j.pain.2013.02.026.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIrritable bowel syndromePositron emission tomographyClinical parametersPatient populationHealthy controlsIBS patientsChronic painInjury-related chronic painChronic visceral painNK-1R signalingPeripheral substance PChronic abdominal painPotential pharmacological interventionsIBD patientsVisceral painAbdominal painCentral sensitizationBowel syndromeBowel diseaseSubstance PPharmacological interventionsBrain expressionPatientsReceptor availability
2011
Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration
Elsworth JD, Groman SM, Jentsch JD, Valles R, Shahid M, Wong E, Marston H, Roth RH. Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology 2011, 62: 1442-1452. PMID: 21875607, PMCID: PMC3711239, DOI: 10.1016/j.neuropharm.2011.08.026.Peer-Reviewed Original ResearchConceptsBrain regionsExecutive functionCognitive dysfunctionPrefrontal cortexCognitive deficitsSubchronic phencyclidine administrationCognition-enhancing effectsDysregulation of neurotransmissionSame brain regionsReversal taskSpecific brain regionsPoor reversalAsenapine effectsOrbitofrontal cortexTrend levelSerotonin turnoverSerotonin utilizationControl monkeysFine motor functionPhencyclidine administrationMotor functionDeficitsDaily administrationNormal monkeysDiscrete brain regions