2023
Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose
Filardi B, Monteiro V, Schwartzmann P, do Prado Martins V, Zucca L, Baiocchi G, Malik A, Silva J, Hahn A, Chen N, Pham K, Pérez-Then E, Miric M, Brache V, Cochon L, Larocca R, Della Rosa Mendez R, Silveira D, Pinto A, Croda J, Yildirim I, Omer S, Ko A, Vermund S, Grubaugh N, Iwasaki A, Lucas C, Initiative Y, Vogels C, Breban M, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W. Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose. Science Translational Medicine 2023, 15: eade6023. PMID: 36791210, DOI: 10.1126/scitranslmed.ade6023.Peer-Reviewed Original ResearchConceptsBooster doseAntibody responseNeutralization titersVirus-specific IgG titersOlder adultsAntiviral humoral immunityPlasma antibody responsesHigh-risk populationSARS-CoV-2 spikeYears of ageAge-dependent impairmentHeterologous regimensBooster dosesBooster vaccineCoronaVac vaccineIgG titersProtective immunityHumoral immunityHumoral responseCoronaVacOmicron waveBooster strategyAge groupsEarly controlVaccine
2022
COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review
Huang D, Zunong J, Li M, Li D, Gong J, Vermund SH, Hu Y. COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review. Current HIV/AIDS Reports 2022, 19: 167-176. PMID: 35394249, PMCID: PMC8990500, DOI: 10.1007/s11904-022-00606-0.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyCOVID-19 clinical severityCOVID-19 clinical presentationCOVID-19Undetectable viral loadAsymptomatic COVID-19Severe COVID-19Last clinical visitCase series/reportsCase fatality rateCOVID-19 prognosisLate antiretroviral therapyIL-6 resultsSARS-CoV-2COVID-19 diagnosisMedian CD4Gastrointestinal symptomsHIV infectionMedian ageRespiratory distressClinical featuresClinical presentationClinical visitsViral loadClinical details
2021
Association of HIV infection and cognitive impairment in older adults: A meta-analysis
Deng L, Zhang X, Gao Y, Turner D, Qian F, Lu H, Vermund SH, Zhang Y, Qian HZ. Association of HIV infection and cognitive impairment in older adults: A meta-analysis. Ageing Research Reviews 2021, 68: 101310. PMID: 33640473, PMCID: PMC10767715, DOI: 10.1016/j.arr.2021.101310.Peer-Reviewed Original ResearchConceptsHIV infectionCognitive impairmentOlder adultsOdds ratioHuman immunodeficiency virus (HIV) infectionMean differenceMotor/psychomotorImmunodeficiency virus infectionMajor cognitive domainsNewcastle-Ottawa ScaleConfidence intervalsRisk of biasPooled odds ratioCross-sectional studyRandom-effects modelIncome countriesCognitive domainsGlobal cognitive impairmentExecutive functionOlder PLWHVirus infectionHigh-income countriesHIVPLWHUpper middle-income countriesFactors associated with past HIV testing among men who have sex with men attending university in China: a cross-sectional study*
Ye R, Liu C, Tan S, Li J, Simoni JM, Turner D, Nelson LE, Vermund SH, Wang N, Qian HZ. Factors associated with past HIV testing among men who have sex with men attending university in China: a cross-sectional study*. Sexual Health 2021, 18: 58-63. PMID: 33639685, PMCID: PMC10767712, DOI: 10.1071/sh20088.Peer-Reviewed Original ResearchConceptsPast HIV testingHIV testing ratesLog-binomial modelsHIV testingStudent MSMTesting ratesMultivariable log-binomial modelsBackground HIV prevalenceHIV testing experiencePositive HIV diagnosisIntervention clinical trialsLow HIV riskCross-sectional studySelf-reported barriersFirst sexual intercourseHIV diagnosisHIV testMedian ageHIV prevalenceClinical trialsHIV riskMSM participantsPositive diagnosisOlder ageBaseline survey
2020
Coinfection With HIV and SARS-CoV-2 in Wuhan, China: A 12-Person Case Series
Hu Y, Ma J, Huang H, Vermund SH. Coinfection With HIV and SARS-CoV-2 in Wuhan, China: A 12-Person Case Series. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 85: 10.1097/qai.0000000000002424. PMID: 32568771, PMCID: PMC7446977, DOI: 10.1097/qai.0000000000002424.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySARS-CoV-2Clinical improvementCase seriesLong-term antiretroviral therapyMild COVID-19 symptomsCOVID-19 coinfectionAcute COVID-19COVID-19 symptomsYears of ageCOVID-19Health care servicesPossible COVID-19 casesCoinfected PersonsAntiretroviral medicationsMedian ageIntensive careCOVID-19 casesClinical prognosisFavorable outcomeSevere symptomsAdditional casesCare servicesHIVInformed consent
2018
Risk Prediction Score for HIV Infection: Development and Internal Validation with Cross-Sectional Data from Men Who Have Sex with Men in China
Yin L, Zhao Y, Peratikos MB, Song L, Zhang X, Xin R, Sun Z, Xu Y, Zhang L, Hu Y, Hao C, Ruan Y, Shao Y, Vermund SH, Qian HZ. Risk Prediction Score for HIV Infection: Development and Internal Validation with Cross-Sectional Data from Men Who Have Sex with Men in China. AIDS And Behavior 2018, 22: 2267-2276. PMID: 29786768, PMCID: PMC7024582, DOI: 10.1007/s10461-018-2129-y.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcohol DrinkingChinaCondomsCross-Sectional StudiesHIV InfectionsHomosexuality, MaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisPrevalenceRisk AssessmentRisk FactorsRisk-TakingSafe SexSexual and Gender MinoritiesSexual BehaviorSexual PartnersSurveys and QuestionnairesSyphilisUnsafe SexYoung AdultConceptsHIV infectionRisk scoreHuman immunodeficiency virus (HIV) riskMultivariable logistic regression modelingBootstrap-corrected C-indexMultiple male sexual partnersValid risk scoreVaccine clinical trialsHigh-risk MSMHigh-risk personsRisk prediction scoreReceptive anal intercourseReceptive anal sexInconsistent condom useMale sexual partnersHIV prevention programmingLogistic regression modelingDrug/alcohol addictionHIV acquisitionRisk reduction programsSyphilis infectionHIV prevalenceClinical trialsC-indexIllegal drug use
2017
Monitoring Anesthesia Care Delivery and Perioperative Mortality in Kenya Utilizing a Provider-driven Novel Data Collection Tool
Sileshi B, Newton MW, Kiptanui J, Shotwell MS, Wanderer JP, Mungai M, Scherdin J, Harris PA, Vermund SH, Sandberg WS, McEvoy MD. Monitoring Anesthesia Care Delivery and Perioperative Mortality in Kenya Utilizing a Provider-driven Novel Data Collection Tool. Anesthesiology 2017, 127: 250-271. PMID: 28657959, PMCID: PMC5519082, DOI: 10.1097/aln.0000000000001713.Peer-Reviewed Original ResearchConceptsPerioperative dataPerioperative mortality rateTertiary referral hospitalMortality rate differencesAnesthesia care deliveryLogistic regression modelsMiddle-income settingsPerioperative mortalityCesarean deliveryEmergency surgeryMiddle-income countriesPerioperative careReferral hospitalSurgery typeSingle centerProcedure typeGeneral surgeryHigh riskMortality rateCare deliveryMortalityData collection periodData collection toolSurgeryRegression models
2016
Frequent HIV Testing
Liu Y, Qian HZ, Ruan Y, Wu P, Osborn CY, Jia Y, Yin L, Lu H, He X, Shao Y, Vermund SH. Frequent HIV Testing. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 72: 452-461. PMID: 27003496, PMCID: PMC4925192, DOI: 10.1097/qai.0000000000001001.Peer-Reviewed Original ResearchConceptsMultivariable logistic regression analysisCurrent HIV infectionHIV incidence reductionHIV testing historyPropensity score adjustmentCubic spline modelingBorderline significant trendLogistic regression analysisHigher testing ratesHIV infectionHIV serostatusPrevious HIVHIV epidemicBeijing MSMTesting ratesScore adjustmentIncidence reductionTesting historyHIVInfection statusBehavioral factorsRegression analysisMSMOddsMenSpousal migration and human papillomavirus infection among women in rural western Nepal
Johnson DC, Lhaki P, Bhatta MP, Kempf MC, Smith JS, Bhattarai P, Aryal S, Chamot E, Regmi K, Vermund SH, Shrestha S. Spousal migration and human papillomavirus infection among women in rural western Nepal. International Health 2016, 8: 261-268. PMID: 27048288, PMCID: PMC4967846, DOI: 10.1093/inthealth/ihw015.Peer-Reviewed Original ResearchConceptsHR-HPV infectionCytology statusHR-HPVHuman papillomavirus (HPV) infection statusAbnormal cervical cytologyHuman papillomavirus infectionAtypical glandular cellsAssociation of migrationPapillomavirus infectionCervical cytologyUndetermined significanceCare centerHigh prevalenceOlder womenBethesda SystemHealth campsStudy participantsOlder ageInfection statusYoung womenGlandular cellsInfectionMigration statusWomenPrevalenceLower HIV Risk Among Circumcised Men Who Have Sex With Men in China
Qian HZ, Ruan Y, Liu Y, Milam DF, Spiegel HM, Yin L, Li D, Shepherd BE, Shao Y, Vermund SH. Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 71: 444-451. PMID: 26413852, PMCID: PMC4767598, DOI: 10.1097/qai.0000000000000856.Peer-Reviewed Original ResearchConceptsLower oddsHIV infectionGenital examinationMale circumcisionVoluntary medical male circumcisionLifetime male sexual partnersHIV heterosexual transmissionMale sexual transmissionLow HIV riskInsertive anal sexInsertive anal intercourseMedical male circumcisionMale sexual partnersAnal sex rolesUncircumcised menCircumcision statusHeterosexual transmissionSexual transmissionInsertive sexClinical trialsHIV riskCircumcision ratesSyphilis riskAnal intercourseLower risk
2015
Poppers use and risky sexual behaviors among men who have sex with men in Beijing, China
Zhang H, Teng T, Lu H, Zhao Y, Liu H, Yin L, Sun Z, He X, Qian HZ, Ruan Y, Shao Y, Vermund SH. Poppers use and risky sexual behaviors among men who have sex with men in Beijing, China. Drug And Alcohol Dependence 2015, 160: 42-48. PMID: 26796594, PMCID: PMC5321169, DOI: 10.1016/j.drugalcdep.2015.11.037.Peer-Reviewed Original ResearchConceptsHIV infectionAnal intercourseMultivariable logistic regression analysisUnprotected receptive anal intercourseSexual behavioral factorsHigh HIV prevalenceReceptive anal intercourseMultiple male sex partnershipsLogistic regression analysisHIV intervention trialsQuarter of menUnprotected anal intercourseSexual behaviorTypes of drugsHIV testingRisky sexual behaviorHIV prevalenceIntervention trialsBlood samplesYounger ageMale partnersAlcohol useMSMSex partnershipsSafer sexHIV testing service awareness and service uptake among female heads of household in rural Mozambique: results from a province-wide survey
Paulin HN, Blevins M, Koethe JR, Hinton N, Vaz L, Vergara AE, Mukolo A, Ndatimana E, Moon TD, Vermund SH, Wester CW. HIV testing service awareness and service uptake among female heads of household in rural Mozambique: results from a province-wide survey. BMC Public Health 2015, 15: 132. PMID: 25881182, PMCID: PMC4339241, DOI: 10.1186/s12889-015-1388-z.Peer-Reviewed Original ResearchConceptsHealth service accessService uptakeVCT servicesRural Zambézia ProvinceHigh HIV prevalencePopulation-based surveyRemote rural settingsConclusionsMost womenRural MozambiqueHigh HIVVoluntary counselingTwo-stage cluster sampleHIV prevalenceProvince-wide surveyService accessHIV stigmaHealth facilitiesZambézia ProvinceStigma scoresTesting utilizationStigma reductionLogistic regressionBaseline measuresSurvey domainsVCT
2014
Current drug use and lack of HIV virologic suppression: point-of-care urine drug screen versus self-report
Qian HZ, Mitchell VJ, Bebawy S, Cassell H, Perez G, McGowan CC, Sterling TR, Vermund SH, D’Aquila R, Hulgan T. Current drug use and lack of HIV virologic suppression: point-of-care urine drug screen versus self-report. BMC Infectious Diseases 2014, 14: 508. PMID: 25234368, PMCID: PMC4175271, DOI: 10.1186/1471-2334-14-508.Peer-Reviewed Original ResearchConceptsUrine drug screensCurrent drug usePositive urine drug screenComputer Assisted Self-InterviewVirologic suppressionDrug useAntiretroviral therapyDrug screensNegative urine drug screensHigher CD4 countsHIV disease progressionRoutine clinic visitsHIV virologic suppressionCross-sectional studyLower self-reported ratesSelf-reported ratesCD4 countClinic visitsPrognostic informationDisease progressionCaucasian raceART usersLower likelihoodResultsAbout halfSelf interviewHIV Risk Perception among HIV Negative or Status-Unknown Men Who Have Sex with Men in China
Fan W, Yin L, Qian HZ, Li D, Shao Y, Vermund SH, Ruan Y, Zhang Z. HIV Risk Perception among HIV Negative or Status-Unknown Men Who Have Sex with Men in China. BioMed Research International 2014, 2014: 232451. PMID: 24795880, PMCID: PMC3985141, DOI: 10.1155/2014/232451.Peer-Reviewed Original ResearchConceptsHIV risk perceptionSelf-perceived riskHIV infectionHigh riskMultivariate logistic regression modelLow self-perceived riskCross-sectional studySelf-reported historyHIV/AIDS epidemicIllicit drug useLogistic regression modelsHIV-negativeHIV testingHIV statusSyphilis testingBeijing MSMChinese MSMHIV perceptionBlood samplesLower riskDrug useHIVMSMUnknown statusAIDS epidemic
2012
Effectiveness of Integrated HIV Prevention Interventions among Chinese Men Who Have Sex with Men: Evaluation of a 16-City Public Health Program
Ye S, Xiao Y, Jin C, Cassell H, Blevins M, Sun J, Vermund SH, Qian HZ. Effectiveness of Integrated HIV Prevention Interventions among Chinese Men Who Have Sex with Men: Evaluation of a 16-City Public Health Program. PLOS ONE 2012, 7: e50873. PMID: 23300528, PMCID: PMC3534092, DOI: 10.1371/journal.pone.0050873.Peer-Reviewed Original ResearchConceptsPublic health programsSelf-reported receiptHIV prevalenceCondom useHealth programsLast sexMultivariable logistic regression analysisMale partnersLow HIV prevalenceHIV prevention interventionsLogistic regression analysisYearly cross-sectional surveysSelf-reported condom useCross-sectional surveyHIV infectionIndependent predictorsHIV epidemicMSM populationPrevention interventionsChinese menDisease ratesEffective interventionsPrevalenceInterventionSex
2011
Prevalence, Incidence, and Recurrence of Oral Lesions Among HIV-Infected Patients on HAART in Alabama
Tamí-Maury IM, Willig JH, Jolly PE, Vermund S, Aban I, Hill JD, Wilson CM, Kempf MC. Prevalence, Incidence, and Recurrence of Oral Lesions Among HIV-Infected Patients on HAART in Alabama. Southern Medical Journal 2011, 104: 561-566. PMID: 21886064, DOI: 10.1097/smj.0b013e318224a15f.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAIDS-Related Opportunistic InfectionsAlabamaAntiretroviral Therapy, Highly ActiveCandidiasis, OralFemaleHIV InfectionsHumansIncidenceLeukoplakia, HairyLongitudinal StudiesMaleMiddle AgedMouth DiseasesOffice VisitsOral UlcerPrevalenceRecurrenceRetrospective StudiesStomatitis, HerpeticYoung AdultConceptsOral lesionsOropharyngeal candidiasisPeriod prevalenceOral conditionsActive antiretroviral therapyAvailability of HAARTLaboratory dataYears of agePatient's laboratory dataAntiretroviral therapyChart reviewHIV infectionRetrospective studyFrequent manifestationIncidence rateMedical careHAARTNew casesPatientsRecurrencePrevalenceIncident rateUniversity of AlabamaHIVLesions
2010
Risk factors and prevalence of tuberculosis, human immunodeficiency virus, syphilis, hepatitis B virus, and hepatitis C virus among prisoners in Pakistan
Kazi AM, Shah SA, Jenkins CA, Shepherd BE, Vermund SH. Risk factors and prevalence of tuberculosis, human immunodeficiency virus, syphilis, hepatitis B virus, and hepatitis C virus among prisoners in Pakistan. International Journal Of Infectious Diseases 2010, 14: e60-e66. PMID: 20189863, PMCID: PMC2905608, DOI: 10.1016/j.ijid.2009.11.012.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHepatitis B virusHepatitis C virusPrevalence of tuberculosisImmunodeficiency virusC virusB virusInjection drug use-related infectionsCommunity-based health providersAcid-fast bacilli smearPost-discharge planningInfectious disease screeningRapid plasma reaginCross-sectional surveyPossible tuberculosisBacilli smearMedian lengthRisk factorsSputum samplesHealth providersDisease screeningSyphilisTuberculosisDrug addictionIllicit drugsPrevalence and Correlates of HIV and Syphilis Infections Among Men Who Have Sex With Men in Seven Provinces in China With Historically Low HIV Prevalence
Xiao Y, Sun J, Li C, Lu F, Allen KL, Vermund SH, Jia Y. Prevalence and Correlates of HIV and Syphilis Infections Among Men Who Have Sex With Men in Seven Provinces in China With Historically Low HIV Prevalence. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2010, 53: s66-s73. PMID: 20104113, DOI: 10.1097/qai.0b013e3181c7db43.Peer-Reviewed Original ResearchConceptsLow HIV prevalenceSyphilis infectionInconsistent condom useHIV prevalenceMSM populationAnal sexCondom usePassive particle agglutination testOlder ageCorrelates of HIVLess educationBehavioral risk factorsRapid plasma reaginParticle agglutination testWestern blot confirmationDetection of TreponemaEnzyme-linked immunosorbentCross-sectional surveyHIV infectionRisk factorsBlood samplesMSM participantsHIVAgglutination testInfectionHuman Immunodeficiency Virus Infection in Alabama Women: Sociodemographic, Behavioral, and Reproductive Health Characteristics and Factors Associated With Lack of Human Immunodeficiency Virus-1 Viral Control
Bhatta MP, Hoesley C, Vermund S. Human Immunodeficiency Virus Infection in Alabama Women: Sociodemographic, Behavioral, and Reproductive Health Characteristics and Factors Associated With Lack of Human Immunodeficiency Virus-1 Viral Control. The American Journal Of The Medical Sciences 2010, 339: 133-140. PMID: 20087169, DOI: 10.1097/maj.0b013e3181c300f9.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBehavioral risk factorsViral controlAlabama womenRisk factorsVirus infectionBlack race/ethnicityT-cell countsCells/microLOutpatient HIV clinicHIV-1 controlReproductive health characteristicsLow viral loadHIV-1 diagnosisBlack womenSelf-administered questionnaireRace/ethnicityAnnual household incomeCervicovaginal lavageAntiretroviral therapyHIV clinicHIV infectionHIV testingSuboptimal access
2007
Complete Blood Cell Count as a Surrogate CD4 Cell Marker for HIV Monitoring in Resource-Limited Settings
Chen RY, Westfall AO, Hardin JM, Miller-Hardwick C, Stringer JS, Raper JL, Vermund SH, Gotuzzo E, Allison J, Saag MS. Complete Blood Cell Count as a Surrogate CD4 Cell Marker for HIV Monitoring in Resource-Limited Settings. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2007, 44: 525-530. PMID: 17259910, DOI: 10.1097/qai.0b013e318032385e.Peer-Reviewed Original ResearchConceptsBirmingham Veterans Affairs Medical CenterTotal lymphocyte countCells/microLCD4 countVeterans Affairs Medical CenterComplete blood cell countAntiretroviral treatment statusLow CD4 cellsBody mass indexBlood cell countCells/Receiver operator characteristic curveResource limited settingsObservational databaseResource-limited settingsCD4 cellsLymphocyte count