2023
High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan
Sanaubarova A, Pujol-Hodge E, Dzissyuk N, Lemey P, Vermund S, Brown A, Ali S. High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan. Viruses 2023, 15: 1407. PMID: 37515095, PMCID: PMC10384832, DOI: 10.3390/v15071407.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySubtype A6Drug-resistant mutationsDrug resistanceEffective antiretroviral therapySuppressive antiretroviral therapyAntiretroviral drug resistanceDrug resistance monitoringHigh-level drug resistanceDrug regimensHIV incidenceHIV epidemicHIV-1Sustained transmissionMolecular epidemiologySubtypesPLHIVHIVG190SDifferent mutational pathwaysMutationsK101ED67NHigh levelsA62V
2013
Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China
Liao L, Xing H, Su B, Wang Z, Ruan Y, Wang X, Liu Z, Lu Y, Yang S, Zhao Q, Vermund SH, Chen RY, Shao Y. Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China. AIDS 2013, 27: 1815-1824. PMID: 23803794, PMCID: PMC3694318, DOI: 10.1097/qad.0b013e3283611931.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyHIV drug resistanceImmunologic failureHigh mortalityVirologic failureAntiretroviral therapyEmergence of HIVDRBaseline CD4 cell countDrug resistanceCD4 cell countCohort of patientsSecond-line drugsEnd of studyProportional hazards modelRural Chinese countiesHIVDR mutationsMedian timePatient adherenceKaplan-MeierChinese patientsRisk factorsHazards modelPatientsCell countMortality
2011
Antiretroviral Drug Resistance Mutations Among Treated and Treatment-Naive Patients in Pakistan: Diversity of the HIV Type 1 pol Gene in Pakistan
Shah S, Xing H, Altaf A, Chen B, Liao L, Jia Y, Vermund SH, Shao Y. Antiretroviral Drug Resistance Mutations Among Treated and Treatment-Naive Patients in Pakistan: Diversity of the HIV Type 1 pol Gene in Pakistan. AIDS Research And Human Retroviruses 2011, 27: 1277-1282. PMID: 21591988, PMCID: PMC3227241, DOI: 10.1089/aid.2010.0324.Peer-Reviewed Original ResearchConceptsInjection drug usersAntiretroviral drugsDrug resistanceAntiretroviral drug resistance mutationsCalibrated Population Resistance toolHIV-1 subtype A1HIV-1-infected participantsPartial reverse transcriptase regionsARV drug resistanceARV-naive patientsPopulation Resistance toolSpouses of HIVTreatment-naive patientsPrimary drug resistanceHIV-1 subtypesDrug resistance mutationsFemale sex workersReverse transcriptase regionBlood spot cardsNaive patientsHIV patientsDrug adherenceSubtype DARV resistancePredominant subtype
2010
Cost comparison of microscopy vs. empiric treatment for malaria in southwestern nigeria: a prospective study
Parikh R, Amole I, Tarpley M, Gbadero D, Davidson M, Vermund SH. Cost comparison of microscopy vs. empiric treatment for malaria in southwestern nigeria: a prospective study. Malaria Journal 2010, 9: 371. PMID: 21176228, PMCID: PMC3152770, DOI: 10.1186/1475-2875-9-371.Peer-Reviewed Original ResearchConceptsEmpiric treatmentAnti-malarial drugsClinical diagnosisClinical malariaGiemsa smearsMajority of patientsUniversity Teaching HospitalCases of malariaRapid diagnostic testsResource-limited settingsCost of diagnosisBody achesHospital chargesProspective studyTreatment optionsPatient costsPediatric regimenTeaching hospitalDiagnostic confirmationEmpirical treatmentThick smearsClinician judgmentAntimalarial drugsDrug resistanceMalaria
2009
Preventing HIV in Developing Countries: Status of Biomedical Interventions
Vermund S. Preventing HIV in Developing Countries: Status of Biomedical Interventions. The FASEB Journal 2009, 23: 199.1-199.1. DOI: 10.1096/fasebj.23.1_supplement.199.1.Peer-Reviewed Original ResearchHIV Prevention Trials NetworkPrevention of motherHIV drug resistanceNeedle exchange programsDNA boostBehavior changeHIV seroconversionHIV seroincidenceEarly therapyPregnant womenHSV-2Clinical trialsHIVMale circumcisionDrug addiction treatmentDrug resistanceTrials NetworkAddiction treatmentBiomedical interventionsSeroincidenceInfantsRisk reductionTherapyPrevention challengesEfficacy
2005
Antiretroviral drugs obtained without prescription for treatment of HIV/AIDS in Pakistan: patient mismanagement as a serious threat for drug resistance.
Shah SA, Altaf A, Khanani R, Vermund SH. Antiretroviral drugs obtained without prescription for treatment of HIV/AIDS in Pakistan: patient mismanagement as a serious threat for drug resistance. Journal Of College Of Physicians And Surgeons Pakistan 2005, 15: 378. PMID: 15924851.Peer-Reviewed Original Research