2018
Activity-Based Protein Profiling at the Host–Pathogen Interface
Kovalyova Y, Hatzios SK. Activity-Based Protein Profiling at the Host–Pathogen Interface. Current Topics In Microbiology And Immunology 2018, 420: 73-91. PMID: 30203396, DOI: 10.1007/82_2018_129.BooksMeSH KeywordsAnimalsCoculture TechniquesDisease Models, AnimalEnzymesHost-Pathogen InteractionsProteomicsConceptsActivity-based protein profilingHost-pathogen interfaceProtein profilingFunctional proteomePathogen interactionsMicrobial pathogenicityComplex proteomesEnzyme-mediated mechanismReactive amino acidsActive enzymeChemical probesAmino acidsMetabolic adaptationProteomeMicrobial infectionsCo-culture systemBiological systemsHost immunityEnzymeProfilingPathogenicityHostProbeAnimal modelsAdaptation
2016
Chemoproteomic profiling of host and pathogen enzymes active in cholera
Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK. Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nature Chemical Biology 2016, 12: 268-274. PMID: 26900865, PMCID: PMC4765928, DOI: 10.1038/nchembio.2025.Peer-Reviewed Original Research
2014
Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4
Munera D, Ritchie JM, Hatzios SK, Bronson R, Fang G, Schadt EE, Davis BM, Waldor MK. Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4. Nature Communications 2014, 5: 3080. PMID: 24445323, PMCID: PMC3905246, DOI: 10.1038/ncomms4080.Peer-Reviewed Original ResearchConceptsEnteroaggregative Escherichia coliIntestinal colonizationAggregative adherenceHaemolytic uraemic syndromeShiga toxin-producing Escherichia coli O104Outbreak of diarrheaIntestinal pathologyUraemic syndromeEscherichia coli O104Diarrhoeal diseaseOutbreak strainShiga toxinDiarrheaColi O104Subset of strainsAdherenceRobust colonizationCultured cellsCharacteristic patternVirulenceSyndromeDiseasePathologyColonization