2018
Activity-Based Protein Profiling at the Host–Pathogen Interface
Kovalyova Y, Hatzios SK. Activity-Based Protein Profiling at the Host–Pathogen Interface. Current Topics In Microbiology And Immunology 2018, 420: 73-91. PMID: 30203396, DOI: 10.1007/82_2018_129.BooksMeSH KeywordsAnimalsCoculture TechniquesDisease Models, AnimalEnzymesHost-Pathogen InteractionsProteomicsConceptsActivity-based protein profilingHost-pathogen interfaceProtein profilingFunctional proteomePathogen interactionsMicrobial pathogenicityComplex proteomesEnzyme-mediated mechanismReactive amino acidsActive enzymeChemical probesAmino acidsMetabolic adaptationProteomeMicrobial infectionsCo-culture systemBiological systemsHost immunityEnzymeProfilingPathogenicityHostProbeAnimal modelsAdaptation
2016
Chemoproteomic profiling of host and pathogen enzymes active in cholera
Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK. Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nature Chemical Biology 2016, 12: 268-274. PMID: 26900865, PMCID: PMC4765928, DOI: 10.1038/nchembio.2025.Peer-Reviewed Original Research
2011
The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis
Hatzios SK, Bertozzi CR. The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis. PLOS Pathogens 2011, 7: e1002036. PMID: 21811406, PMCID: PMC3141025, DOI: 10.1371/journal.ppat.1002036.Peer-Reviewed Original ResearchMeSH KeywordsHost-Pathogen InteractionsHumansMacrophages, AlveolarMycobacterium tuberculosisSulfatesSulfurTuberculosisConceptsSulfate assimilation pathwayAssimilation pathwayDiverse environmental cuesMycobacterium tuberculosisBiosynthesis of moleculesHost immune cellsSmall molecule regulatorsSuccessful human pathogenSulfur metabolismRegulatory cuesMtb infectionGranuloma formationImmune cellsEnvironmental cuesRegulatory proteinsSulfur-containing metabolitesMolecule regulatorsAlveolar macrophagesTherapeutic interventionsMetabolism regulationBiochemical mechanismsIntracellular pathogensMetabolic adaptationHuman pathogensTuberculosis