2018
Activity-Based Protein Profiling at the Host–Pathogen Interface
Kovalyova Y, Hatzios SK. Activity-Based Protein Profiling at the Host–Pathogen Interface. Current Topics In Microbiology And Immunology 2018, 420: 73-91. PMID: 30203396, DOI: 10.1007/82_2018_129.BooksConceptsActivity-based protein profilingHost-pathogen interfaceProtein profilingFunctional proteomePathogen interactionsMicrobial pathogenicityComplex proteomesEnzyme-mediated mechanismReactive amino acidsActive enzymeChemical probesAmino acidsMetabolic adaptationProteomeMicrobial infectionsCo-culture systemBiological systemsHost immunityEnzymeProfilingPathogenicityHostProbeAnimal modelsAdaptation
2011
The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis
Hatzios SK, Bertozzi CR. The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis. PLOS Pathogens 2011, 7: e1002036. PMID: 21811406, PMCID: PMC3141025, DOI: 10.1371/journal.ppat.1002036.Peer-Reviewed Original ResearchConceptsSulfate assimilation pathwayAssimilation pathwayDiverse environmental cuesMycobacterium tuberculosisBiosynthesis of moleculesHost immune cellsSmall molecule regulatorsSuccessful human pathogenSulfur metabolismRegulatory cuesMtb infectionGranuloma formationImmune cellsEnvironmental cuesRegulatory proteinsSulfur-containing metabolitesMolecule regulatorsAlveolar macrophagesTherapeutic interventionsMetabolism regulationBiochemical mechanismsIntracellular pathogensMetabolic adaptationHuman pathogensTuberculosis