2021
Tumor Infiltrating Lymphocytes Target HLA-I Phosphopeptides Derived From Cancer Signaling in Colorectal Cancer
Penny SA, Abelin JG, Malaker SA, Myers PT, Saeed AZ, Steadman LG, Bai DL, Ward ST, Shabanowitz J, Hunt DF, Cobbold M. Tumor Infiltrating Lymphocytes Target HLA-I Phosphopeptides Derived From Cancer Signaling in Colorectal Cancer. Frontiers In Immunology 2021, 12: 723566. PMID: 34504498, PMCID: PMC8421858, DOI: 10.3389/fimmu.2021.723566.Peer-Reviewed Original ResearchMeSH KeywordsCD8-Positive T-LymphocytesCell Line, TumorColorectal NeoplasmsHistocompatibility Antigens Class IHumansLymphocytes, Tumor-InfiltratingPhosphopeptidesT-Lymphocytes, CytotoxicConceptsT cell responsesColorectal cancerCRC patientsPatient tumorsTumor antigensCell responsesPeripheral T cell responsesCytotoxic T-cell infiltrationFuture immunotherapeutic strategiesCRC liver metastasesNovel immunotherapeutic targetT cell infiltrationTumor-Infiltrating LymphocytesTumor-specific antigensPrimary CRC tumorsCRC cell linesKey prognostic indicatorMarker of malignancyCRC patient tumorsMultifunctional CD8Immunotherapeutic strategiesLiver metastasesInfiltrating lymphocytesCytokine responsesSame HLA
2017
Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles
Pavlos R, McKinnon EJ, Ostrov DA, Peters B, Buus S, Koelle D, Chopra A, Schutte R, Rive C, Redwood A, Restrepo S, Bracey A, Kaever T, Myers P, Speers E, Malaker SA, Shabanowitz J, Jing Y, Gaudieri S, Hunt DF, Carrington M, Haas DW, Mallal S, Phillips EJ. Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles. Scientific Reports 2017, 7: 8653. PMID: 28819312, PMCID: PMC5561238, DOI: 10.1038/s41598-017-08876-0.Peer-Reviewed Original ResearchConceptsHypersensitivity reactionsHLA moleculesTreatment-limiting hypersensitivity reactionClass IDrug hypersensitivity syndromeHuman leukocyte antigen (HLA) systemHLA class IHLA-C allelesClass II allelesLeukocyte antigen systemHLA-B allelesNevirapine hypersensitivityHypersensitivity syndromeHLA associationsIndependent associationHLA-DRB1T cellsImmune responseNovel risk allelesPathogenic mechanismsDrug specific interactionsMultiple class IAntigen systemPrimary predispositionRisk allelesPeptide-binding motifs of two common equine class I MHC molecules in Thoroughbred horses
Bergmann T, Lindvall M, Moore E, Moore E, Sidney J, Miller D, Tallmadge RL, Myers PT, Malaker SA, Shabanowitz J, Osterrieder N, Peters B, Hunt DF, Antczak DF, Sette A. Peptide-binding motifs of two common equine class I MHC molecules in Thoroughbred horses. Immunogenetics 2017, 69: 351-358. PMID: 28315936, PMCID: PMC5555743, DOI: 10.1007/s00251-017-0978-6.Peer-Reviewed Original ResearchAmino Acid MotifsAnimalsEpitopes, T-LymphocyteGenes, MHC Class IHaplotypesHistocompatibility Antigens Class IHorsesPeptide FragmentsProtein BindingProtein Domains