2024
Single-cell transcriptomics of CD8 T cells in autoimmune diabetes after anti-CD3 monoclonal antibody treatment
Wu Y, Spurrell M, Deng S, Herold K. Single-cell transcriptomics of CD8 T cells in autoimmune diabetes after anti-CD3 monoclonal antibody treatment. The Journal Of Immunology 2024, 212: 0998_4625-0998_4625. DOI: 10.4049/jimmunol.212.supp.0998.4625.Peer-Reviewed Original ResearchPancreas-draining lymph nodesIslet-infiltrating CD8 T cellsCD8 T cellsPre-diabetic NODAnti-CD3 mAbDiverse TCR repertoireT cellsNOD miceTCR repertoireTCF-1Pre-diabetic NOD miceImmune mediated destructionDiabetic NOD miceMonoclonal antibody treatmentLong-term toleranceExpression of EomesExpression of TCF-1Expression of TOXFragments of mAbsDelay type 1 diabetesType 1 diabetesAnti-CD3Autoimmune diabetesAntibody treatmentLymph nodes
2013
Transplant Tolerance to Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen
Gagliani N, Jofra T, Valle A, Stabilini A, Morsiani C, Gregori S, Deng S, Rothstein DM, Atkinson M, Kamanaka M, Flavell RA, Roncarolo MG, Battaglia M. Transplant Tolerance to Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen. American Journal Of Transplantation 2013, 13: 1963-1975. PMID: 23834659, PMCID: PMC3869180, DOI: 10.1111/ajt.12333.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntibodies, MonoclonalCD4 AntigensCD4-Positive T-LymphocytesForkhead Transcription FactorsGraft SurvivalIslets of LangerhansIslets of Langerhans TransplantationLeukocyte Common AntigensMiceMice, Inbred BALB CMice, Inbred C57BLSpleenT-Lymphocytes, RegulatoryTransplantation ToleranceTransplantation, HomologousConceptsTr1 cellsLong-term toleranceTransplant toleranceRegulatory type 1 (Tr1) cellsSpecific immunomodulatory treatmentTreg cell transferCD25- T cellsRegulatory cell typesType 1 cellsAllograft toleranceImmunomodulatory treatmentTreg cellsAllogeneic transplantationT cellsMouse modelImmune systemTregsPancreatic isletsSpleenAllograftsCell typesCellsRegulatory functionsTransplantationEngraftment