2021
What makes the psychosis ‘clinical high risk’ state risky: psychosis itself or the co-presence of a non-psychotic disorder?
Hasmi L, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Richards A, Lin B, O'Donovan M, Luykx J, Rutten B, Guloksuz S, van Os J. What makes the psychosis ‘clinical high risk’ state risky: psychosis itself or the co-presence of a non-psychotic disorder? Epidemiology And Psychiatric Sciences 2021, 30: e53. PMID: 34225831, PMCID: PMC8264801, DOI: 10.1017/s204579602100041x.Peer-Reviewed Original ResearchConceptsNon-psychotic disordersClinical high-risk stateClinical high riskHigh-risk stateHigh riskPsychotic symptomsPsychotic experiencesProspective general population cohortEarly psychotic experiencesIncident psychotic experiencesGeneral population cohortHealth service usePsychosis risk statesDrug use disordersPositive family historySchizophrenia polygenic risk scoresPsychosis incidenceAntipsychotic medicationYearly incidenceFamily historyPolygenic risk scoresRisk scoreAPS researchPRS-SZService use
2013
Minor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodes
İnce B, Guloksuz S, Altınbaş K, Oral E, Alpkan L, Altinoz M. Minor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodes. Journal Of Affective Disorders 2013, 151: 405-408. PMID: 23856286, DOI: 10.1016/j.jad.2013.06.042.Peer-Reviewed Original ResearchConceptsBipolar disorderEpisode densityProtective roleDisease severityLikely protective roleBrain blood flowElectro-convulsive therapyPositive family historyTotal body weightEuthymic BD patientsHigh-performance liquid chromatographyMyocardial anginaLarge comparative studiesIntermittent hypoxiaHemoglobin levelsCardiac outputDisease characteristicsBD patientsHypoxia hypothesisPostpartum episodesHbF increaseFamily historySevere bipolar disorderBlood flowDrug regimes