2022
Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther supportAge- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
Paquin V, Pries L, ten Have M, Bak M, Gunther N, de Graaf R, van Dorsselaer S, Lin B, van Eijk K, Kenis G, Richards A, O’Donovan M, Luykx J, Rutten B, van Os J, Shah J, Guloksuz S. Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population. Social Psychiatry And Psychiatric Epidemiology 2022, 58: 43-52. PMID: 35913550, PMCID: PMC9845157, DOI: 10.1007/s00127-022-02346-3.Peer-Reviewed Original ResearchConceptsSex-specific associationsSelf-reported healthPRS-SCZES-SCZPhysical healthGeneral populationNetherlands Mental Health SurveyIncidence Study-2Mental Health SurveyHealth SurveyRisk scoreAge 65Common genetic variantsHealth correlatesAge 18Poor healthOlder individualsMental healthPolygenic riskLinear mixed modelsAgeSexExposome scoreHealthAssociation
2021
Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status
Pasman J, Demange P, Guloksuz S, Willemsen A, Abdellaoui A, ten Have M, Hottenga J, Boomsma D, de Geus E, Bartels M, de Graaf R, Verweij K, Smit D, Nivard M, Vink J. Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status. Behavior Genetics 2021, 52: 92-107. PMID: 34855049, PMCID: PMC8860781, DOI: 10.1007/s10519-021-10094-4.Peer-Reviewed Original ResearchConceptsLifetime smokingSocioeconomic statusNetherlands Mental Health SurveyMental healthIncidence Study-2Mental Health SurveyNeighborhood socioeconomic statusGenome-wide association studiesGenetic liabilityHealth SurveySmokingGene-environment interactionsEducational attainmentEA effectNetherlands Twin RegisterSmoking traitsGenetic riskPolygenic scoresEtiology of smokingPredictive profilesTwin RegisterSES characteristicsUK BiobankReliable predictorHealth
2020
Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia
Pries L, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Lin B, van Eijk K, Kenis G, Richards A, O’Donovan M, Luykx J, Rutten B, Guloksuz S. Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia. JAMA Psychiatry 2020, 77: 1296-1304. PMID: 32805017, PMCID: PMC7711318, DOI: 10.1001/jamapsychiatry.2020.2304.Peer-Reviewed Original ResearchConceptsRecent stressful life eventsStressful life eventsAssociations of SLEsPoor physical healthMental health outcomesHealth outcomesPhysical healthGeneral populationPopulation-based prospective cohort studyPRS-SCZNetherlands Mental Health SurveyES-SCZMental healthProspective cohort studyIncidence Study-2Modifiable environmental factorsAdulthood stressful life eventsMental Health SurveyDutch general populationPoor mental healthPopulation-based health outcomesLife eventsCohort studyMean ageHealth SurveyDo Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?
Marsman A, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Luykx J, Rutten B, Guloksuz S, van Os J. Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health? Schizophrenia Bulletin 2020, 46: 1353-1362. PMID: 33259628, PMCID: PMC7707067, DOI: 10.1093/schbul/sbaa086.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAgedFamilyFemaleGenetic Predisposition to DiseaseHealth SurveysHumansLife Change EventsLongitudinal StudiesMaleMarijuana UseMiddle AgedMultifactorial InheritanceNetherlandsPsychotic DisordersSchizophreniaSocioeconomic FactorsUrban PopulationYoung AdultConceptsPolygenic risk scoresSchizophrenia polygenic risk scoresMental healthFamily historyNetherlands Mental Health SurveyPopulation-based studyPolygenic riskChildhood traumaMental Health SurveyMental health changesEnvironmental risk factorsGeneral mental healthPopulation mental healthGeneral population sampleSomatic painRisk factorsHealth SurveyRisk scorePRS-SZBipolar disorderEpidemiological settingsMental disordersHealth changesAttributable variationPainM126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY
Pries L, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Li B, Luykx J, Rutten B, van Os J, Guloksuz S. M126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY. Schizophrenia Bulletin 2020, 46: s183-s183. PMCID: PMC7234581, DOI: 10.1093/schbul/sbaa030.438.Peer-Reviewed Original ResearchAdult stressful life eventsAssociations of SLEsStressful life eventsGeneral populationPhysical healthMental healthHealth SurveyHealth outcomesShort Form-36 Health SurveyNetherlands Mental Health SurveyImpact of SLEsRecent stressful life eventsProspective cohort studyPrevious health statusMental Health SurveyDutch general populationLife eventsCohort studyProspective surveyPolygenic risk scoresRisk scoreGene-environment interactionsGenetic predispositionHealth statusSchizophrenia
2018
The Complexities of Evaluating the Exposome in Psychiatry: A Data-Driven Illustration of Challenges and Some Propositions for Amendments
Guloksuz S, Rutten B, Pries L, Have M, de Graaf R, van Dorsselaer S, Klingenberg B, van Os J, Ioannidis J, Group T. The Complexities of Evaluating the Exposome in Psychiatry: A Data-Driven Illustration of Challenges and Some Propositions for Amendments. Schizophrenia Bulletin 2018, 44: 1175-1179. PMID: 30169883, PMCID: PMC6192470, DOI: 10.1093/schbul/sby118.Peer-Reviewed Original ResearchConceptsMental health outcomesHealth outcomesNetherlands Mental Health SurveyMental Health SurveyPre-specified analysis planFalsification endpointsModifiable factorsSources of heterogeneityHealth SurveyIntervention effectsSelective reportingAnalysis planP-valueOutcomesEffect sizeVibration of effectsAnalytical planSame outcomeDifferent studiesExploratory analysisExposureStudy 2 dataP-value thresholdReasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population
Reininghaus U, Rauschenberg C, Have M, de Graaf R, van Dorsselaer S, Simons CJP, Gunther N, Pries LK, Guloksuz S, Radhakrishnan R, Bak M, van Os J. Reasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population. Psychological Medicine 2018, 49: 1799-1809. PMID: 30160228, DOI: 10.1017/s0033291718002209.Peer-Reviewed Original ResearchConceptsComposite International Diagnostic InterviewAffective disturbancesPsychotic experiencesNetherlands Mental Health SurveySecond Netherlands Mental Health SurveyTransdiagnostic phenotypeJTC biasMental Health SurveyDose-response relationshipGeneral population sampleHealth SurveyGeneral populationIncidence studyHelp-seeking behaviorDiagnostic InterviewTime pointsMemory performanceConclusions reasoning biasPopulation sampleRecent findingsPhenotypeDigit span taskIndividualsFindingsPsychosisT115. REASONING BIAS, WORKING MEMORY PERFORMANCE, AND A TRANSDIAGNOSTIC PHENOTYPE OF AFFECTIVE DISTURBANCES AND PSYCHOTIC EXPERIENCES IN THE GENERAL POPULATION
Rauschenberg C, Reininghaus U, Have M, de Graaf R, van Dorsselaer S, Gunther N, Pries L, Guloksuz S, Radhakrishnan R, Bak M, van Os J. T115. REASONING BIAS, WORKING MEMORY PERFORMANCE, AND A TRANSDIAGNOSTIC PHENOTYPE OF AFFECTIVE DISTURBANCES AND PSYCHOTIC EXPERIENCES IN THE GENERAL POPULATION. Schizophrenia Bulletin 2018, 44: s160-s161. PMCID: PMC5888643, DOI: 10.1093/schbul/sby016.391.Peer-Reviewed Original ResearchComposite International Diagnostic InterviewHelp-seeking behaviorAffective disturbancesGeneral populationPsychotic experiencesTransdiagnostic phenotypeNetherlands Mental Health SurveyJTC biasSecond Netherlands Mental Health SurveyMental Health SurveyRepresentative general population sampleDose-response relationshipGeneral population sampleMemory performanceSocio-demographic characteristicsRisk factorsHealth SurveyIncidence studySocio-environmental factorsDiagnostic InterviewCognitive deficitsMental healthSymptom domainsTime pointsPsychosis
2016
Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network
Guloksuz S, van Nierop M, Bak M, de Graaf R, ten Have M, van Dorsselaer S, Gunther N, Lieb R, van Winkel R, Wittchen H, van Os J. Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network. BMC Psychiatry 2016, 16: 223. PMID: 27391407, PMCID: PMC4939022, DOI: 10.1186/s12888-016-0935-1.Peer-Reviewed Original ResearchConceptsMental disordersSymptom dimensionsNetherlands Mental Health SurveyNEMESIS-1Symptom connectivityContinuous symptom dimensionsEnvironmental exposuresSelf-report Symptom Checklist-90Mental Health SurveySymptom Checklist-90Health SurveyPsychotic symptomsIncidence studyPopulation cohortSelf-reported psychopathologyConclusionsOur findingsDiagnostic categoriesSymptom domainsIndependent population cohortsRisk loadPsychopathology StudyDisordersRegression analysisCohortSymptoms