2024
Associations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences
Ku B, Yuan Q, Arias-Magnasco A, Lin B, Walker E, Druss B, Ren J, van Os J, Guloksuz S. Associations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences. Schizophrenia Bulletin 2024, sbae141. PMID: 39171674, DOI: 10.1093/schbul/sbae141.Peer-Reviewed Original ResearchPhysical activityPRS-SCZDistressing psychotic-like experiencesPsychotic-like experiencesDevelopment of psychosisMechanisms of physical activityGenetic liabilityParticipants of European ancestryPolygenic risk scoresIncome-to-needs ratioBody mass indexAssociated with trajectoriesAssociated with less riskAdolescent Brain Cognitive Development StudyAssociated with impaired functionFamily history of psychosisLinear mixed modelsGeneralized linear mixed modelsCognitive Development StudyHistory of psychosisEuropean ancestryGenetic riskFamily historyMass indexRisk score
2022
Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study
Pries L, Moore T, Visoki E, Sotelo I, Barzilay R, Guloksuz S. Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study. Biological Psychiatry Global Open Science 2022, 2: 283-291. PMID: 36325038, PMCID: PMC9616253, DOI: 10.1016/j.bpsgos.2022.05.005.Peer-Reviewed Original ResearchPregnancy/birth complicationsExposome factorsGeneral psychopathologyBirth complicationsCognitive Development StudyGeneral psychopathology factorAdolescent Brain Cognitive Development (ABCD) studyClinical symptomsAdjusted modelMultiple comparison correctionExposome approachLinear regression analysisMental disordersNeurodevelopmental psychopathologyChildhood adversityPsychosisEnvironmental exposuresABCD studyNongenetic factorsComplicationsRegression analysisPsychopathology factorNeighborhood environmentPsychopathologyExposomeModeling environment through a general exposome factor in two independent adolescent cohorts
Moore T, Visoki E, Argabright S, Didomenico G, Sotelo I, Wortzel J, Naeem A, Gur R, Gur R, Warrier V, Guloksuz S, Barzilay R. Modeling environment through a general exposome factor in two independent adolescent cohorts. Exposome 2022, 2: osac010. PMID: 36606125, PMCID: PMC9798749, DOI: 10.1093/exposome/osac010.Peer-Reviewed Original ResearchExposome factorsOverall psychopathologyAdolescent cohortPubertal developmentEnvironmental exposuresAdvanced pubertal developmentSex-matched sampleKey health-related outcomesHealth-related outcomesCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyGeneral healthCohortPhiladelphia Neurodevelopmental CohortConsistent associationABCD studyObesityNeurodevelopmental CohortParental educationExposurePsychopathologyFactorsPhysical environmental stimuli