2024
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol
Ghovanloo M, Effraim P, Tyagi S, Zhao P, Dib-Hajj S, Waxman S. Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications Biology 2024, 7: 120. PMID: 38263462, PMCID: PMC10805714, DOI: 10.1038/s42003-024-05781-x.Peer-Reviewed Original ResearchConceptsDorsal root ganglionDorsal root ganglion neuronal excitabilityDorsal root ganglion neuronsNeuronal excitabilityCurrent-clamp analysisSteady-state inactivationVoltage-dependent sodiumSlow inactivated stateAutomated patch clamp platformMultielectrode array recordingsNav currentsNeuropathic painSodium currentRoot ganglionGanglion neuronsSlow inactivationInactivated stateCurrent inhibitorsIon channelsNeuronsInhibitory effectCannabinolArray recordingsEndocannabinoidCannabinoid
2019
A mutation in CaV2.1 linked to a severe neurodevelopmental disorder impairs channel gating
Tyagi S, Bendrick TR, Filipova D, Papadopoulos S, Bannister RA. A mutation in CaV2.1 linked to a severe neurodevelopmental disorder impairs channel gating. The Journal Of General Physiology 2019, 151: 850-859. PMID: 31015257, PMCID: PMC6571999, DOI: 10.1085/jgp.201812237.Peer-Reviewed Original Research