2020
High-throughput quantitative histology in systemic sclerosis skin disease using computer vision
Correia C, Mawe S, Lofgren S, Marangoni RG, Lee J, Saber R, Aren K, Cheng M, Teaw S, Hoffmann A, Goldberg I, Cowper SE, Khatri P, Hinchcliff M, Mahoney JM. High-throughput quantitative histology in systemic sclerosis skin disease using computer vision. Arthritis Research & Therapy 2020, 22: 48. PMID: 32171325, PMCID: PMC7071594, DOI: 10.1186/s13075-020-2127-0.Peer-Reviewed Original ResearchConceptsSystemic sclerosisFibrosis scoreQuantitative image featuresBiopsy scorePrimary cohortOutcome measuresSecondary cohortDiagnostic scoreSkin severity scoreSSc clinical trialsRodnan skin scoreLogistic regression modelsControl biopsiesRegression modelsSkin scoreSeverity scoreClinical hallmarkClinical trialsForearm biopsiesSSc skinBiopsy sectionsIndependent cohortPatient basisSSc biopsiesCollagen deposition
2019
Pathology of spontaneous and immunotherapy‐induced tumor regression in a murine model of melanoma
Blenman KRM, Wang J, Cowper S, Bosenberg M. Pathology of spontaneous and immunotherapy‐induced tumor regression in a murine model of melanoma. Pigment Cell & Melanoma Research 2019, 32: 448-457. PMID: 30702217, PMCID: PMC6500596, DOI: 10.1111/pcmr.12769.Peer-Reviewed Original ResearchConceptsTumor regressionB cellsMelanoma cellsNeutrophil extracellular trapsNeutrophil countAdverse reactionsGeographic necrosisNeutrophil responseExtracellular trapsHistological changesPlasma cellsMurine modelHost responseTumor microenvironmentImmunotherapyNeutrophilsTumorsRegression modelsCellsRegressionLike formationImmunocompetentPlasmablastsEpithelioidMelanoma