2022
miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo.
Luo W, Kim Y, Jensen M, Herlea-Pana O, Wang W, Rudolph M, Friedman J, Chernausek S, Jiang S. miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo. Diabetes 2022, 71: 2360-2371. PMID: 36001751, PMCID: PMC9630090, DOI: 10.2337/db22-0205.Peer-Reviewed Original ResearchConceptsBeige adipogenesisMiR-301bMiR-130bPeroxisome proliferator-activated receptor γ coactivator 1αProliferator-activated receptor γ coactivator 1αImproved glucose toleranceReceptor γ coactivator 1αLess weight gainPotential therapeutic targetCold-induced energy expenditureΓ coactivator 1αMitochondrial biogenesisMetabolic complicationsVisceral adiposityGlucose toleranceThermogenic brownCounteract obesityMetabolic disordersTherapeutic targetAdipose tissueBeige phenotypeMetabolic diseasesAdipose progenitor cellsBeige adipocytesCoactivator 1α
2020
Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes
Jiang S, Teague A, Tryggestad J, Jensen M, Chernausek S. Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes. Scientific Reports 2020, 10: 8314. PMID: 32433500, PMCID: PMC7239922, DOI: 10.1038/s41598-020-65415-0.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAdultAMP-Activated Protein KinasesAnimalsCohort StudiesDiabetes, GestationalDiet, High-FatDNA MethylationEpigenesis, GeneticFemaleHistonesHumansMaleMetforminMiceMice, Inbred C57BLMitochondriaOrganelle BiogenesisPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPlacentaPregnancyPregnancy in DiabeticsPromoter Regions, GeneticSex FactorsConceptsActivation of AMP-activated protein kinaseMitochondrial biogenesisPGC-1a expressionH3K27 acetylationAMP-activated protein kinaseRegulator of mitochondrial biogenesisMitochondrial transcription factor ASubgroup of diabetic womenAssociated with epigenetic regulationPGC-1aAberrant epigenetic alterationsLevels of H3K27 acetylationOffspring long-term healthProliferator-activated receptor gamma coactivator 1-alphaPeroxisome proliferator-activated receptor gamma coactivator 1-alphaPromoter methylationTranscription factor AImpaired mitochondrial biogenesisIncreased promoter methylationGamma coactivator 1-alphaDecreased histone acetylationIncreased H3K27 acetylationCoactivator 1-alphaLong-term healthCapability of metformin
2019
Macrophage‐Derived microRNA‐155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator‐Activated Receptor Gamma
Tryggestad J, Teague A, Sparling D, Jiang S, Chernausek S. Macrophage‐Derived microRNA‐155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator‐Activated Receptor Gamma. Obesity 2019, 27: 1856-1864. PMID: 31531958, PMCID: PMC6832842, DOI: 10.1002/oby.22616.Peer-Reviewed Original ResearchConceptsAdipose tissue macrophagesMiR-155Mesenchymal stem cellsStem cellsPeripheral blood mononuclear cellsPeroxisome proliferator-activated receptor gammaBlood mononuclear cellsImpact of obesityProliferator-activated receptor gammaInfluence adipocyte metabolismMiR-130b expressionCell type-specific fashionIncreased 1.8-foldType-specific fashionPPARG mRNA expressionWestern blot analysisMononuclear cellsPolymerase chain reactionQuantitative polymerase chain reactionMiRNA expressionHuman mesenchymal stem cellsTissue macrophagesDifferentiated 3T3-L1 adipocytesMRNA expressionObesity