2023
AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells
Wu J, Gulati S, Teague A, Kim Y, Tryggestad J, Jiang S. AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells. Stem Cells And Development 2023, 32: 131-139. PMID: 36594575, PMCID: PMC9986020, DOI: 10.1089/scd.2022.0226.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesCell DifferentiationDNA MethylationDNA, MitochondrialEpigenesis, GeneticFemaleHumansMesenchymal Stem CellsMuscle DevelopmentPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPregnancyConceptsActivation of AMP-activated protein kinasePGC-1a expressionMitochondrial programDNA methylationCompound CMitochondrial biogenesisAMPK activationActivation of AMPKAMP-activated protein kinaseAMPK inhibitor compound CInhibition of DNA methylationRegulator of mitochondrial biogenesisRegulate mitochondrial biogenesisPGC-1aInhibitor compound CPromoter methylationIncreased mitochondrial functionRegulation of energy metabolismMitochondrial DNAEpigenetic landscapeDNA demethylationMtDNA abundanceMyogenic differentiationEpigenetic regulationProtein kinase
2020
Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes
Jiang S, Teague A, Tryggestad J, Jensen M, Chernausek S. Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes. Scientific Reports 2020, 10: 8314. PMID: 32433500, PMCID: PMC7239922, DOI: 10.1038/s41598-020-65415-0.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAdultAMP-Activated Protein KinasesAnimalsCohort StudiesDiabetes, GestationalDiet, High-FatDNA MethylationEpigenesis, GeneticFemaleHistonesHumansMaleMetforminMiceMice, Inbred C57BLMitochondriaOrganelle BiogenesisPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPlacentaPregnancyPregnancy in DiabeticsPromoter Regions, GeneticSex FactorsConceptsActivation of AMP-activated protein kinaseMitochondrial biogenesisPGC-1a expressionH3K27 acetylationAMP-activated protein kinaseRegulator of mitochondrial biogenesisMitochondrial transcription factor ASubgroup of diabetic womenAssociated with epigenetic regulationPGC-1aAberrant epigenetic alterationsLevels of H3K27 acetylationOffspring long-term healthProliferator-activated receptor gamma coactivator 1-alphaPeroxisome proliferator-activated receptor gamma coactivator 1-alphaPromoter methylationTranscription factor AImpaired mitochondrial biogenesisIncreased promoter methylationGamma coactivator 1-alphaDecreased histone acetylationIncreased H3K27 acetylationCoactivator 1-alphaLong-term healthCapability of metformin
2017
Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis
Jiang S, Teague A, Tryggestad J, Aston C, Lyons T, Chernausek S. Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis. Placenta 2017, 57: 26-32. PMID: 28864016, PMCID: PMC5659203, DOI: 10.1016/j.placenta.2017.06.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood GlucoseDiabetes, GestationalDNA, MitochondrialDNA-Binding ProteinsFemaleHumansLongitudinal StudiesMaleMitochondrial ProteinsOrganelle BiogenesisPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPlacentaPregnancySex FactorsTranscription FactorsYoung AdultConceptsMtDNA contentResponse to maternal diabetesMitochondrial biogenesisMitochondrial DNAPGC-1aEffects of maternal diabetesMaternal diabetesRegulator of mitochondrial biogenesisTranscription factor AImpaired mitochondrial biogenesisMitochondria transcription factor ABiogenesis pathwayMetabolic diseasesMtDNAFetal sex-specific differencesCopy numberTFAM levelsGene expressionMale offspringBiogenesisAbnormal placental functionTFAMNon-diabetic womenOffspring sexIndex of mitochondrial biogenesisRole of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway
Jiang S, Teague A, Tryggestad J, Chernausek S. Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway. Biochemical And Biophysical Research Communications 2017, 487: 607-612. PMID: 28433632, PMCID: PMC5522006, DOI: 10.1016/j.bbrc.2017.04.099.Peer-Reviewed Original ResearchMeSH KeywordsDNA-Binding ProteinsHumansMicroRNAsMitochondriaMitochondrial ProteinsOrganelle BiogenesisOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReactive Oxygen SpeciesTranscription FactorsTumor Cells, CulturedConceptsMiR-130b-3pPGC-1a expressionPGC-1aReactive oxygen speciesMicroRNA-130bExpression of miR-130b-3pRegulator of mitochondrial biogenesisMitochondrial transcription factor ADecreased protein abundanceTranscription factor AOffspring long-term healthResponse to high glucoseCells to high glucoseHigh glucoseMitochondrial biogenesis signalingLong-term healthOxidative stressMitochondrial biogenesisMitochondrial functionBeWo cellsTFAM expressionBiogenesis signalingMolecular mechanismsDownstream factorsHigh-glucose treatment