2020
Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
Jiang S, Teague A, Tryggestad J, Lyons T, Chernausek S. Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis. Molecular Medicine 2020, 26: 76. PMID: 32762639, PMCID: PMC7409642, DOI: 10.1186/s10020-020-00205-y.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAdultBiomarkersBlood GlucoseCase-Control StudiesDiabetes, GestationalDNA, MitochondrialFemaleFetal BloodHumansLeukocytes, MononuclearMaternal ExposureMesenchymal Stem CellsMitochondriaOrganelle BiogenesisPlacentaPregnancyPrenatal Exposure Delayed EffectsResistinStress, PhysiologicalTrophoblastsConceptsCord blood mononuclear cellsBlood mononuclear cellsSecretion of resistinHuman resistinMononuclear cellsBeWo cellsCultured cord blood mononuclear cellsMeasures of maternal glycemiaMesenchymal stem cellsLong-term health of offspringExposed BeWo cellsImpact fetal developmentPlacental mitochondrial contentCirculation of infantsPlacental trophoblast cellsHuman placental explantsAdipocyte-derived factorsHealth of offspringMaternal glycemiaResponse to high glucoseDiabetic pregnanciesFetal circulationMaternal diabetesCord bloodCord sera
2018
Regulation and Role of Human Resistin in Diabetes during Pregnancy
JIANG S, TEAGUE A, TRYGGESTAD J, LYONS T, CHERNAUSEK S. Regulation and Role of Human Resistin in Diabetes during Pregnancy. Diabetes 2018, 67 DOI: 10.2337/db18-1401-p.Peer-Reviewed Original ResearchCord blood mononuclear cellsDiabetic pregnanciesHuman resistinCultured cord blood mononuclear cellsMeasures of maternal glycemiaEffects of maternal diabetesLong-term health of offspringImpact fetal developmentOffspring of diabetic pregnancyPlacental trophoblast cellsBlood mononuclear cellsSecretion of resistinHuman term placentaAdipocyte-derived factorsHealth of offspringMaternal glycemiaResponse to high glucoseFetal circulationMaternal diabetesPlacental functionCord seraFetal developmentResistin levelsTerm placentaResistin concentrations
2017
Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway
Jiang S, Teague A, Tryggestad J, Chernausek S. Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway. Biochemical And Biophysical Research Communications 2017, 487: 607-612. PMID: 28433632, PMCID: PMC5522006, DOI: 10.1016/j.bbrc.2017.04.099.Peer-Reviewed Original ResearchConceptsMiR-130b-3pPGC-1a expressionPGC-1aReactive oxygen speciesMicroRNA-130bExpression of miR-130b-3pRegulator of mitochondrial biogenesisMitochondrial transcription factor ADecreased protein abundanceTranscription factor AOffspring long-term healthResponse to high glucoseCells to high glucoseHigh glucoseMitochondrial biogenesis signalingLong-term healthOxidative stressMitochondrial biogenesisMitochondrial functionBeWo cellsTFAM expressionBiogenesis signalingMolecular mechanismsDownstream factorsHigh-glucose treatment