2017
Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway
Jiang S, Teague A, Tryggestad J, Chernausek S. Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway. Biochemical And Biophysical Research Communications 2017, 487: 607-612. PMID: 28433632, PMCID: PMC5522006, DOI: 10.1016/j.bbrc.2017.04.099.Peer-Reviewed Original ResearchConceptsMiR-130b-3pPGC-1a expressionPGC-1aReactive oxygen speciesMicroRNA-130bExpression of miR-130b-3pRegulator of mitochondrial biogenesisMitochondrial transcription factor ADecreased protein abundanceTranscription factor AOffspring long-term healthResponse to high glucoseCells to high glucoseHigh glucoseMitochondrial biogenesis signalingLong-term healthOxidative stressMitochondrial biogenesisMitochondrial functionBeWo cellsTFAM expressionBiogenesis signalingMolecular mechanismsDownstream factorsHigh-glucose treatment
2016
Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA.
Tryggestad J, Vishwanath A, Jiang S, Mallappa A, Teague A, Takahashi Y, Thompson D, Chernausek S. Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. Clinical Science 2016, 130: 1955-67. PMID: 27562513, PMCID: PMC5516927, DOI: 10.1042/cs20160305.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusMiR-130bMiR-let-7a-5pMiR-148aLevel of miR-130bHuman umbilical vein endothelial cellsMiR-148a-3pMiR-30c-5pMiR-148a mimicsInfants of womenMiR-130b-3pMiRNA expressionMiR-452MiR-126Influence of gestational diabetes mellitusDiabetes mellitusTarget protein expressionProtein expressionTarget protein abundanceMiRNAsMonths of ageUmbilical vein endothelial cellsMiRNA speciesQuantitative PCRFetal tissues